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Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1
01 September 2010
Wenjing Zhang, Jide Wang, Bing Zou, Claude Sardet, Jianming Li, Colin S.C. Lam, Lui Ng, Roberta Pang, Ivan F.N. Hung, Victoria P.Y. Tan, Bo Jiang, Benjamin C.Y. Wong
Abstract: E-cadherin is a hallmark of epithelial–mesenchymal transition (EMT), which plays a crucial role in cancer metastasis. We previously demonstrated that four and a half LIM protein 2 (FHL2) inh...
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Expression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) by colorectal cancer cells and adjacent stroma cells – Associations with histopathology and patients outcome
01 September 2010
Søren Astrup Jensen, Ben Vainer, Annette Bartels, Nils Brünner, Jens Benn Sørensen
Abstract: Aim: To elucidate cellular features accountable for colorectal cancers’ (CRC) capability to invade normal tissue and to metastasize, we investigated the level of the collagenase matrix metal...
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Downregulation of miR-21 modulates Ras expression to promote apoptosis and suppress invasion of Laryngeal squamous cell carcinoma
01 September 2010
Jingyuan Ren, Dan Zhu, Ming Liu, Yanan Sun, Linli Tian
Abstract: MiRNAs are small, noncoding RNA molecules that emerge as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been caus...
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Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α
30 August 2010
Antonella Naldini, Irene Filippi, Diego Miglietta, Michele Moschetta, Raffaella Giavazzi, Fabio Carraro
Abstract: The casual relationship between inflammation and tumour progression has been widely accepted and the etiology of breast cancer has been associated with inflammatory processes. Interleukin (I...
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Early cessation of the clinical development of LiPlaCis, a liposomal cisplatin formulation
30 August 2010
Maja J.A. de Jonge, Marije Slingerland, Walter J. Loos, Erik A.C. Wiemer, Herman Burger, Ron H.J. Mathijssen, Judith R. Kroep, Margret A.G. den Hollander, Diane van der Biessen, Mei-Ho Lam, Jaap Verweij, Hans Gelderblom
Abstract: Purpose: To evaluate the safety and tolerability of LiPlaCis, a liposomal formulated platinum compound, in patients with solid tumours and to determine the maximum tolerated dose (MTD) of in...
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