European Journal of Cancer
Volume 37, Issue 3 , Pages 414-421 , February 2001

Effects of electrochemotherapy with bleomycin on normal liver tissue in a rat model

  • M.J. Jaroszeski

      Affiliations

    • Department of Surgery, MDC Box 16, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    • Center for Molecular Delivery, University of South Florida, Tampa, FL 33612-4799, USA
    • Corresponding Author InformationCorresponding author at first address. Tel.: +1-813-974-4662; fax: +1-813-974-2669
    • ,
  • D. Coppola

      Affiliations

    • G.I. Tumor Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    • Department of Pathology, MDC11, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    • ,
  • G. Nesmith

      Affiliations

    • Department of Surgery, MDC Box 16, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    • ,
  • C. Pottinger

      Affiliations

    • Department of Surgery, MDC Box 16, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    • ,
  • M. Hyacinthe

      Affiliations

    • G.I. Tumor Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    • ,
  • K. Benson

      Affiliations

    • Department of Pathology, MDC11, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    • ,
  • R. Gilbert

      Affiliations

    • Center for Molecular Delivery, University of South Florida, Tampa, FL 33612-4799, USA
    • Department of Chemical Engineering, ENB 118, College of Engineering, University of South Florida, 2202E Fowler Avenue, Tampa, FL 33620, USA
    • ,
  • R. Heller

      Affiliations

    • Department of Surgery, MDC Box 16, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    • Center for Molecular Delivery, University of South Florida, Tampa, FL 33612-4799, USA
    • Cutaneous Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    • Department of Medical Microbiology, University of South Florida, Tampa, FL 33612-4799, USA

Received 2 May 2000 ,Revised 29 September 2000 ,Accepted 2 October 2000.

References 

  1. Heller R, Jaroszeski M, Leo-Messina J, et al.  Treatment of B16 melanoma with the combination of electroporation and chemotherapy. Bioelectrochem. Bioenerget. 1995;36:83–87
  2. Heller R, Jaroszeski M, Perrott R, Messina J, Gilbert R. Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy. Melanoma Res. 1997;7:10–18
  3. Mir LM, Orlowski S, Belehradek J, Paoletti C. Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer. 1991;27A:68–72
  4. Sersa G, Cemazar M, Miclavcic D, Mir LM. Electrochemotherapy (variable anti-tumor effect on different tumor models). Bioelectrochem. Bioenerget. 1994;35:23–27
  5. Pendez S, Jaroszeski MJ, Gilbert R, et al.  Direct delivery of chemotherapeutic agents for the treatment of hepatomas and sarcomas in rat models. Radiol. Oncol. 1998;21:53–64
  6. Hyacinthe M, Jaroszeski MJ, Dang VV, et al.  Electrically enhanced drug delivery for the treatment of soft tissue sarcoma. Cancer. 1999;85:409–417
  7. Belehradek J, Orlowski S, Poddevin B, Paoletti C, Mir LM. Electrochemotherapy of spontaneous mammary tumors in mice. Eur. J. Cancer. 1991;27A:73–76
  8. Jaroszeski MJ, Gilbert R, Perrott R, Heller R. Enhanced effects of multiple treatment electrochemotherapy. Melanoma Res. 1996;6:427–433
  9. Rols MP, Teissie J. Electropermeabilization of mammalian cells. Biophys. J. 1990;58:1089–1098
  10. Teissie J. Time course of Electropermeabilization. In:  Allen MJ,  Cleary SF,  Sowers AE,  Shillady DD editor. Charge and Field Effects in Biosystems — 3. Boston: Birkhauser; 1992;p. 285–301
  11. Cemazar M, Miklavcic D, Vodovnik L, et al.  Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization on EAT tumor model in mice. Radiol. Oncol. 1995;29:121–127
  12. Heller R, Jaroszeski MJ, Glass LF, et al.  Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer. 1996;77:964–971
  13. Heller R, Jaroszeski MJ, Reintgen DS, et al.  Treatment of cutaneous tumors with electrochemotherapy using intralesional bleomcyin. Cancer. 1998;83:148–157
  14. Belehradek M, Domenge C, Luboinnski B, Orlowski S, Belehradek J, Mir LM. Electrochemotherapy, a new antitumor treatment. Cancer. 1993;71:3694–3700
  15. Domenge C, Orlowski S, Luboinski B, et al.  Antitumor electrochemotherapy. Cancer. 1996;77:956–963
  16. Rudolf Z, Stabuc B, Cemazar M, Miklavcic D, Vodovnik L, Sersa G. Electrochemotherapy with bleomycin. The first clinical experience in malignant melanoma patients. Radiol. Oncol. 1995;29:229–235
  17. Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z. Electrochemotherapy with Cisplatin (potentiation of local Cisplatin antitumor effectiveness by application of electric pulses in cancer patients). Eur. J. Cancer. 1998;34:1213–1218
  18. Mir LM, Glass LF, Sersa G, et al.  Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br. J. Cancer. 1998;77:2336–2342
  19. Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin (clinical experience in malignant melanoma patients). Clin. Cancer Res. 2000;6:863–867
  20. Panje WR, Hier M, Garman GR, Harrell E, Goldman A, Bloch I. Electroporation therapy of head and neck cancer. Ann. Otol. Rhinol. Laryngol. 1998;107:779–785
  21. American Cancer Society, Inc. Cancer Facts & Figures. New York: American Cancer Society; 1997;
  22. Venook AP. Treatment of hepatocellular carcinoma (too many options?). J. Clin. Oncol. 1994;12:1323–1334
  23. Beasley RP. Hepatitis B virus as the etiologic agent in hepatocellular carcinoma — epidemiologic considerations. Hepatology. 1982;2:21S–26S
  24. Ikeda K, Saitoh S, Koida I, et al.  A multivariate analysis of risk factors for hepatocellular carcinogenesis (a prospective observation of 795 patients with viral and alcoholic cirrhosis). Hepatology. 1993;18:47–53
  25. Liu CL, Fan ST. Nonresectional therapies for hepatocellular carcinoma. Am. J. Surg. 1997;173:358–365
  26. Jaroszeski MJ, Gilbert R, Heller R. In vivo antitumor effects of electrochemotherapy in a hepatoma model. Biochim. Biophys. Acta. 1997;1334:15–18
  27. Ramirez LH, Orlowski S, An D, et al.  Electrochemotherapy on liver tumours in rabbits. Br. J. Cancer. 1998;77:2104–2111
  28. Chazal M, Benchimol D, Baque P, Pierrefite V, Milano G, Bourgeon A. Treatment of hepatic metastases of colorectal cancer by electrochemotherapy (an experimental study in the rat). Surgery. 1998;124:536–540
  29. Gilbert RA, Jaroszeski MJ, Heller R. Novel electrode designs for electrochemotherapy. Biochim. Biophys. Acta. 1997;1334:9–14
  30. Heller R, Gilbert R, Jaroszeski MJ. Clinical applications of electrochemotherapy. Adv. Drug Deliv. Rev. 1999;35:119–129
  31. Jaroszeski MJ, Gilbert R, Heller R. Electrochemotherapy (an emerging drug delivery method for the treatment of cancer). Adv. Drug Deliv. Rev. 1991;26:185–197

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European Journal of Cancer
Volume 37, Issue 3 , Pages 414-421 , February 2001

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