European Journal of Cancer
Volume 40, Issue 4 , Pages 494-502 , March 2004

Aberrant expression of interleukin-7 (IL-7) and its signalling complex in human breast cancer

Received 31 March 2003 ,Revised 4 August 2003 ,Accepted 24 October 2003.

References 

  1. Touw I, Pouwels K, van Agthoven T, et al.  Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia. Blood. 1990;75:2097–2101
  2. Eder M, Ottmann OG, Hansen-Hagge TE, et al.  In vitro culture of common acute lymphoblastic leukemia blasts (effects of interleukin-3, interleukin-7, and accessory cells). Blood. 1992;79:3274–3284
  3. Frishman J, Long B, Knospe W, Gregory S, Plate J. Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia. J. Exp. Med. 1993;177:955–964
  4. Digel W, Schmid M, Heil G, Conrad P, Gillis S, Porzsolt F. Human interleukin-7 induces proliferation of neoplastic cells from chronic lymphocytic leukemia and acute leukemias. Blood. 1991;78:753–759
  5. Dalloul A, Laroche L, Bagot M, et al.  Interleukin-7 is a growth-factor for Sezary lymphoma-cells. Journal of Clinical Investigation. 1992;90:1054–1060
  6. Foss HD, Hummel M, Gottstein S, et al.  Frequent expression of IL-7 gene transcripts in tumor cells of classical Hodgkin's disease. Am. J. Pathol. 1995;146:33–39
  7. Qin JZ, Zhang CL, Kamarashev J, Dummer R, Burg G, Dobbeling U. Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. Blood. 2001;98:2778–2783
  8. Watanabe M, Ueno Y, Yajima T, et al.  Interleukin-7 is produced by human intestinal epithelial-cells and regulates the proliferation of intestinal mucosal lymphocytes. Journal of Clinical Investigation. 1995;95:2945–2953
  9. Maeurer MJ, Walter W, Martin D, et al.  Interleukin-7 (IL-7) in colorectal cancer (IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes). Scand. J. Immunol. 1997;45:182–192
  10. Cosenza L, Gorgun G, Urbano A, Foss F. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cell Signal. 2002;14:317–325
  11. Oka M, Hirose K, Iizuka N, et al.  Cytokine mRNA expression patterns in human esophageal cancer cell lines. J. Interferon Cytokine Res. 1995;15:1005–1009
  12. Trinder P, Seitzer U, Gerdes J, Seliger B, Maeurer M. Constitutive and IFN-gamma regulated expression of IL-7 and IL-15 in human renal cell cancer. Int. J. Oncol. 1999;14:23–31
  13. Paleri V, Pulimood A, Davies GR, Birchall MA. Interleukins 7 and 12 are expressed in head and neck squamous cancer. Clin. Otolaryngol. 2001;26:302–306
  14. Takeuchi T, Yamanouchi H, Yue Q, Ohtsuki Y. Epithelial component of lymphoid stroma-rich Warthin's tumour expresses interleukin (IL)-7. Histopathology. 1998;32:383–384
  15. Al-Rawi M, Mansel R, Jiang W. Interleukin-7 is a putative lymphangiogenic factor in endothelial cells. Breast Cancer Res. Treat. 2002;76(Suppl. 1):S166
  16. Al-Rawi M, Mansel R, Jiang W. Interleukin-7 induces the growth of breast cancer cells. Br. J. Surgery. 2003;90(Suppl.):106
  17. Foxwell BMJ, Beadling C, Guschin D, Kerr I, Cantrell D. Interleukin-7 can induce the activation of Jak-1, Jak-3 and Stat-5 proteins in murine T-Cells. Eur. J. Immunol. 1995;25:3041–3046
  18. Lin JX, Migone TS, Tsang M, et al.  The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by Il-2, Il-4, Il-7, Il-13, and Il-15. Immunity. 1995;2:331–339
  19. Pernis A, Gupta S, Yopp J, et al.  Gamma-chain-associated cytokine receptors signal through distinct transducing factors. J. Biol. Chem. 1995;270:14517–14522
  20. Dadi H, Ke S, Roifman CM. Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein-tyrosine kinase-activity. Blood. 1994;84:1579–1586
  21. Cance WG, Liu ET. Protein-kinases in human breast-cancer. Breast Cancer Res. Treat. 1995;35:105–114
  22. Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature. 1997;387:673–676
  23. Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD. Phosphoinositide 3-kinases (a conserved family of signal transducers). Trends Biochem. Sci. 1997;22:267–272
  24. Sun M, Paciga JE, Feldman RI, et al.  Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ER alpha) via interaction between ER alpha and PI3K. Cancer Res. 2001;61:5985–5991
  25. Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene. 2000;19:2474–2488
  26. Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997;11:179–186
  27. Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. U.S.A. 1995;92:8831–8835
  28. Watson CJ, Miller WR. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer. 1995;71:840–844
  29. Migone TS, Lin JX, Cereseto A, et al.  Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science. 1995;269:79–81
  30. Weber-Nordt RM, Egen C, Wehinger J, et al.  Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood. 1996;88:809–816
  31. Zhang Q, Nowak I, Vonderheid EC, et al.  Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc. Natl. Acad. Sci. U.S.A. 1996;93:9148–9153
  32. Gouilleux-Gruart V, Gouilleux F, Desaint C, et al.  STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 1996;87:1692–1697
  33. Catlett-Falcone R, Dalton WS, Jove R. STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr. Opin. Oncol. 1999;11:490–496
  34. Grandis JR, Drenning SD, Chakraborty A, et al.  Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J. Clin. Invest. 1998;102:1385–1392
  35. Garcia R, Yu CL, Hudnall A, et al.  Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 1997;8:1267–1276
  36. Sartor CI, Dziubinski ML, Yu CL, Jove R, Ethier SP. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res. 1997;57:978–987
  37. Dhir R, Ni Z, Lou W, DeMiguel F, Grandis JR, Gao AC. Stat3 activation in prostatic carcinomas. Prostate. 2002;51:241–246
  38. Horiguchi A, Oya M, Shimada T, Uchida A, Marumo K, Murai M. Activation of signal transducer and activator of transcription 3 in renal cell carcinoma (a study of incidence and its association with pathological features and clinical outcome). J. Urol. 2002;168:762–765
  39. Fernandes A, Hamburger AW, Gerwin BI. ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells. Int. J. Cancer. 1999;83:564–570
  40. Huang M, Page C, Reynolds RK, Lin J. Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. Gynecol. Oncol. 2000;79:67–73
  41. Coppola D. Molecular prognostic markers in pancreatic cancer. Cancer Control. 2000;7:421–427
  42. Pansky A, Hildebrand P, Fasler-Kan E, et al.  Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. Int. J. Cancer. 2000;85:720–725
  43. Whitcombe D, Kelly S, Mann J, Theaker J, Jones C, Little S. Scorpions (TM) primers—a novel method for use in single-tube genotyping. Am. J. Human Genet. 1999;65:2333
  44. Whitcombe D, Theaker J, Guy SP, Brown T, Little S. Detection of PCR products using self-probing amplicons and fluorescence. Nat. Biotechnol. 1999;17:804–807
  45. Cunnick GH, Jiang WG, Gomez KF, Mansel RE. Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model. Biochem. Biophys. Res. Commun. 2001;288:1043–1046
  46. Todd JH, Dowle C, Williams MR, et al.  Confirmation of a prognostic index in primary breast-cancer. Br. J. Cancer. 1987;56:489–492
  47. Kasahara T, Mukaida N, Yamashita K, Yagisawa H, Akahoshi T, Matsushima K. IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology. 1991;74:60–67
  48. Mizuno K, Sone S, Orino E, Mukaida N, Matsushima K, Ogura T. Spontaneous production of interleukin-8 by human lung cancer cells and its augmentation by tumor necrosis factor alpha and interleukin-1 at protein and mRNA levels. Oncology. 1994;51:467–471
  49. Yasumoto K, Okamoto S, Mukaida N, Murakami S, Mai M, Matsushima K. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. J. Biol. Chem. 1992;267:22506–22511
  50. Ristimaki A, Narko K, Enholm B, Joukov V, Alitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J. Biol. Chem. 1998;273:8413–8418
  51. Cayeux S, Beck C, Aicher A, Dorken B, Blankenstein T. Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines. Eur. J. Immunol. 1995;25:2325–2331
  52. Talmadge JE, Jackson JD, Kelsey L, Borgeson CD, Faltynek C, Perry GA. T-cell reconstitution by molecular, phenotypic, and functional analysis in the thymus, bone marrow, spleen, and blood following split-dose polychemotherapy and therapeutic activity for metastatic breast cancer in mice. J. Immunother. 1993;14:258–268
  53. Wang MB, Lichtenstein A, Mickel RA. Hierarchical immunosuppression of regional lymph nodes in patients with head and neck squamous cell carcinoma. Otolaryngol. Head Neck Surg. 1991;105:517–527
  54. Oka M, Mitsunaga H, Hazama S, Yoshino S, Suzuki T. Natural killer activity and serum immunosuppressive acidic protein levels in esophageal and gastric cancers. Surg. Today. 1993;23:669–674
  55. Banerji S, Ni J, Wang SX, et al.  LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 1999;144:789–801
  56. Breiteneder-Geleff S, Matsui K, Soleiman A, et al.  Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am. J. Pathol. 1997;151:1141–1152
  57. Plate KH. From angiogenesis to lymphangiogenesis. Nat. Med. 2001;7:151–152
  58. Zeng YX, Takahashi H, Shibata M, Hirokawa K. Jak3 Janus kinase is involved in interleukin-7 signal pathway. Febs Lett. 1994;353:289–293
  59. Johnston JA, Bacon CM, Finbloom DS, et al.  Tyrosine phosphorylation and activation of Stat5, Stat3, and Janus kinases by interleukin-2 and interleukin-15. Proc. Natl Acad. Sci. USA. 1995;92:8705–8709

PII: S0959-8049(03)00926-2

doi: 10.1016/j.ejca.2003.10.016

European Journal of Cancer
Volume 40, Issue 4 , Pages 494-502 , March 2004

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