European Journal of Cancer
Volume 40, Issue 4 , Pages 571-578 , March 2004

Severity of enterocolitis is predicted by IL-8 in paediatric oncology patients

  • M.D van de Wetering

      Affiliations

    • Emma Children's Hospital, Academic Medical Center, F8-245, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31-20-566-3050; fax: +31-20-691-2231
    • ,
  • H.N Caron

      Affiliations

    • Emma Children's Hospital, Academic Medical Center, F8-245, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • ,
  • M Biezeveld

      Affiliations

    • Emma Children's Hospital, Academic Medical Center, F8-245, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • ,
  • J.A.J.M Taminiau

      Affiliations

    • Emma Children's Hospital, Academic Medical Center, F8-245, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • ,
  • F.J ten Kate

      Affiliations

    • Department of Pathology, Amsterdam, The Netherlands
    • ,
  • L Spanjaard

      Affiliations

    • Department of Medical Microbiology, Amsterdam, The Netherlands
    • ,
  • T.W Kuijpers

      Affiliations

    • Emma Children's Hospital, Academic Medical Center, F8-245, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Received 8 May 2003 ,Revised 15 September 2003 ,Accepted 31 October 2003.

References 

  1. Gandy W, Greenberg BR. Successful medical management of neutropenic enterocolitis. Cancer. 1983;51:1551–1555
  2. Gartell P, Braye SG, Copplestone JA. Neutropenic typhlitis. Dis Colon Rectum. 1984;27:274–275
  3. Gomez L, Martino R, Rolston KV. Neutropenic enterocolitis (spectrum of the disease and comparison of definite and possible cases). Clin Infect Dis. 1998;27:695–699
  4. Shamberger RC, Weinstein HJ, Delorey MJ, Levey RH. The medical and surgical management of typhlitis in children with acute nonlymphocytic (myelogenous) leukaemia. Cancer. 1986;57:603–609
  5. Cooke X. Submucosal hemorrhage and appendiceal perforation in children with leukaemia. JAMA. 1933;101:432–435
  6. Lev R, Sweeney KG. Neutropenic enterocolitis. Two unusual cases with review of the literature. Arch Pathol Lab Med. 1993;117:524–527
  7. Wade DS, Nava HR, Douglass HO. Neutropenic enterocolitis. Clinical diagnosis and treatment. Cancer. 1992;69:17–23
  8. Blijlevens NM, Donnelly JP, De Pauw BE. Mucosal barrier injury (biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview). Bone Marrow Transplant. 2000;25:1269–1278
  9. Engervall P, Andersson B, Bjorkholm M. Clinical significance of serum cytokine patterns during start of fever in patients with neutropenia. Br J Haematol. 1995;91:838–845
  10. de Bont ES, Vellenga E, Swaanenburg JC, et al.  Plasma IL-8 and IL-6 levels can be used to define a group with low risk of septicaemia among cancer patients with fever and neutropenia. Br J Haematol. 1999;107:375–380
  11. Engel A, Mack E, Kern P, Kern WV. An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients. Infection. 1998;26:213–221
  12. Kern WV, Heiss M, Steinbach G. Prediction of gram-negative bacteremia in patients with cancer and febrile neutropenia by means of interleukin-8 levels in serum (targeting empirical monotherapy versus combination therapy). Clin Infect Dis. 2001;32:832–835
  13. Fleischhack G, Kambeck I, Cipic D, Hasan C, Bode U. Procalcitonin in paediatric cancer patients (its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II). Br J Haematol. 2000;111:1093–1102
  14. Berkes J, Viswanathan VK, Savkovic SD, Hecht G. Intestinal epithelial responses to enteric pathogens (effects on the tight junction barrier, ion transport, and inflammation). Gut. 2003;52:439–451
  15. Karakurum M, Shreeniwas R, Chen J, et al.  Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J. Clin. Invest. 1994;93:1564–1570
  16. Wolbink GJ, Brouwer MC, Buysmann S, ten Berge IJ, Hack CE. CRP-mediated activation of complement in vivo (assessment by measuring circulating complement-C-reactive protein complexes). J. Immunol. 1996;157:473–479
  17. Moir DH, Turner JJ, Ma DD, Biggs JC. Autopsy findings in bone marrow transplantation. Pathology. 1982;14:197–204
  18. Prolla JC, Kirsner JB. The gastrointestinal lesions and complications of the leukaemia's. Ann Intern Med. 1964;61:1084–1103
  19. Baerg J, Murphy JJ, Anderson R, Magee JF. Neutropenic enteropathy (a 10-year review). J Pediatr Surg. 1999;34:1068–1071
  20. Anand A, Bashey B, Mir T, Glatt AE. Epidemiology, clinical manifestations, and outcome of Clostridium difficile-associated diarrhoea. Am J Gastroenterol. 1994;89:519–523
  21. Riley TV. Clostridium difficile (a pathogen of the nineties). Eur J Clin Microbiol Infect Dis. 1998;17:137–141
  22. Wagner ML, Rosenberg HS, Fernbach DJ, Singleton EB. Typhlitis (a complication of leukaemia in childhood). Am J Roentgenol Radium Ther Nucl Med. 1970;109:341–350
  23. Katz JA, Wagner ML, Gresik MV, Mahoney DH, Fernbach DJ. Typhlitis. An 18-year experience and postmortem review. Cancer. 1990;65:1041–1047
  24. Song HK, Kreisel D, Canter R, et al.  Changing presentation and management of neutropenic enterocolitis. Arch Surg. 1998;133:979–982
  25. Woo PC, Wong SS, Lum PN, Hui WT, Yuen KY. Cell-wall-deficient bacteria and culture-negative febrile episodes in bone-marrow-transplant recipients. Lancet. 2001;357:675–679
  26. Sloas MM, Flynn PM, Kaste SC, Patrick CC. Typhlitis in children with cancer (a 30-year experience). Clin Infect Dis. 1993;17:484–490
  27. Cartoni C, Dragoni F, Micozzi A, et al.  Neutropenic enterocolitis in patients with acute leukaemia: prognostic significance of bowel wall thickening detected by ultrasonography. J Clin Oncol. 2001;19:756–761
  28. Gorschluter M, Marklein G, Hofling K, et al.  Abdominal infections in patients with acute leukaemia: a prospective study applying ultrasonography and microbiology. Br J Haematol. 2002;117:351–358
  29. van Woensel JB, Biezeveld MH, Alders AM, et al.  Adrenocorticotropic hormone and cortisol levels in relation to inflammatory response and disease severity in children with meningococcal disease. J Infect Dis. 2001;184:1532–1537
  30. Colgan SP, Dzus AL, Parkos CA. Epithelial exposure to hypoxia modulates neutrophil transepithelial migration. J. Exp. Med. 1996;184:1003–1015
  31. Tilg H, Dinarello CA, Mier JW. IL-6 and APPs (anti-inflammatory and immunosuppressive mediators). Immunol. Today. 1997;18:428–432

PII: S0959-8049(03)00936-5

doi: 10.1016/j.ejca.2003.10.021

European Journal of Cancer
Volume 40, Issue 4 , Pages 571-578 , March 2004

Article Tools

* Image Usage & Resolution