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European Journal of Cancer
Volume 42, Issue 15
, Pages 2425-2432
, October 2006
A genomic explanation connecting “Mediterranean diet”, olive oil and cancer: Oleic acid, the main monounsaturated Fatty acid of olive oil, induces formation of inhibitory “PEA3 transcription factor-PEA3 DNA binding site” complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells
References
- Dietary fat, olive oil intake and breast cancer risk. Int J Cancer. 1994;58:774–780
- . Diet and risk of breast cancer in Spain. Eur J Cancer Prev. 1994;3:313–320
- Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl Cancer Inst. 1995;87:110–116
- Olive oil, other dietary fats, and the risk of breast cancer. Cancer Causes Control. 1995;6:545–550
- Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European Community Multicenter Study on antioxidants, myocardial infarction, and breast cancer. Am J Clin Nutr. 1998;68:134–141
- Olive oil, diet and colorectal cancer: an ecological study and a hypothesis. J Epidemiol Community Health. 2000;54:756–760
- Olive oil, other seasoning fats, and the risk of colorectal carcinoma. Cancer. 1998;82:448–453
- Diet and ovarian cancer: a case-control study in Greece. Int J Cancer. 1993;55:411–414
- Dietary factors and the risk of endometrial cancer: a case-control study in Greece. Br J Cancer. 1996;73:1284–1290
- Olive oil: influence and benefits on some pathologies. An Med Interna. 2004;21:138–142
- . The role of olive oil in lowering cancer risk: is the real gold or simply pinchbeck?. J Epidemiol Community Health. 2000;54:726–727
- Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells. Ann Oncol. 2004;15:1719–1721
- Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu gene amplification. Ann Oncol. 2005;16:359–371
- Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 1986;319:230–234
- . The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature. 1986;319:226–230
- . Take your partners, please–signal diversification by the erbB family of receptor tyrosine kinases. Growth Factors. 1999;16:255–263
- . Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2:127–137
- Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177–182
- Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 1989;244:707–712
- . The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Stem Cells. 1998;16:413–428
- erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science. 1987;237:178–182
- . Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumourigenesis of NIH 3T3 cells. Proc Natl Acad Sci USA. 1987;84:7159–7163
- . Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities. Cancer Res. 1997;57:1199–1205
- . The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol Neoplasia. 2001;6:393–406
- . Role of erbB2 in breast cancer chemosensitivity. Bioessays. 2000;22:673–680
- . Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer. Endocrinol Relat Cancer. 2001;8:191–195
- . Natural medicine: a ‘new frontier’ in oncology?. Ann Oncol. 2005;16:339–340
- . Oleic acid suppresses overexpression of ERBB2 oncogene. Lancet Oncol. 2005;6:69
- Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumour cell lines by different molecular mechanisms. EMBO J. 1987;6:605–610
- . Transcriptional regulation of type I receptor tyrosine kinases in the mammary gland. J Mammary Gland Biol Neoplasia. 1997;2:153–163
- . Update on HER-2 as a target for cancer therapy. The ERBB2 promoter and its exploitation for cancer treatment. Breast Cancer Res. 2001;3:395–398
- . The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc Natl Acad Sci USA. 1995;92:744–747
- A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. Oncogene. 1996;13:1701–1707
- Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers. Br J Cancer. 2003;89:899–906
- The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumourigenesis. Nat Med. 2000;6:189–195
- . Transcriptional targeting of the HER-2/neu oncogene. Drugs Today (Barc). 2000;36:835–843
- Estrogen-dependent, tamoxifen-resistant tumourigenic growth of MCF-7 cells transfected with Her-2/neu. Breast Cancer Res Treat. 1993;24:85–95
- Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA. 1992;89:4285–4289
- Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol. 1996;14:737–744
- Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol. 1999;17:2639–2648
- Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20:719–726
- Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783–792
- CI-1033, an irreversible pan-erbB receptor inhibitor and its potential for the treatment of breast cancer. Semin Oncol. 2003;30(5 Suppl. 16):65–78
- . Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist. 2004;9(Suppl. 3):10–15
- Targeting HER2: recent developments and future directions for breast cancer patients. Semin Oncol. 2001;28(6 Suppl 18):21–29
- Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst. 2001;93:1852–1857
- PTEN activation contributes to tumour inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell. 2004;6:117–127
- Ets regulation of the erbB2 promoter. Oncogene. 2000;19(2):153–163
PII: S0959-8049(05)00935-4
doi: 10.1016/j.ejca.2005.10.016
© 2005 Elsevier Ltd. All rights reserved.
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European Journal of Cancer
Volume 42, Issue 15
, Pages 2425-2432
, October 2006
