European Journal of Cancer
Volume 43, Issue 14 , Pages 2082-2092 , September 2007

Granulocyte transfusions in neutropaenic children: A systematic review of the literature

  • M.D. van de Wetering

      Affiliations

    • Emma Children’s Hospital, Academic Medical Centre (AMC), Amsterdam, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel.: +31 20 566 3050; fax: +31 20 691 2231.
    • ,
  • N. Weggelaar

      Affiliations

    • Emma Children’s Hospital, Academic Medical Centre (AMC), Amsterdam, The Netherlands
    • ,
  • M. Offringa

      Affiliations

    • Emma Children’s Hospital, Academic Medical Centre (AMC), Amsterdam, The Netherlands
    • Center for Clinical Epidemiological in Pediatrics, AMC, Amsterdam, The Netherlands
    • ,
  • H.N. Caron

      Affiliations

    • Emma Children’s Hospital, Academic Medical Centre (AMC), Amsterdam, The Netherlands
    • ,
  • T.W. Kuijpers

      Affiliations

    • Emma Children’s Hospital, Academic Medical Centre (AMC), Amsterdam, The Netherlands

Received 26 March 2007 ,Revised 18 July 2007 ,Accepted 19 July 2007.

References 

  1. Coleman MP, Gatta G, Verdecchia A, et al. EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century. Ann Oncol. 2003;14(Suppl 5):v128–v149
  2. Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med. 1966;64:328–340
  3. Lucas KG, Brown AE, Armstrong D, Chapman D, Heller G. The identification of febrile, neutropaenic children with neoplastic disease at low risk for bacteremia and complications of sepsis. Cancer. 1996;77:791–798
  4. Verhoef J, Verhage EA, Visser MR. A decade of experience with selective decontamination of the digestive tract as prophylaxis for infections in patients in the intensive care unit: what have we learned?. Clin Infect Dis. 1993;17:1047–1054
  5. Strumia MM. The Effect of leukocytic cream injections in the treatment of the neutropenias. Am J Med Sci. 1934;187:527–544
  6. Vamvakas EC, Pineda AA. Determinants of the efficacy of prophylactic granulocyte transfusions: a meta-analysis. J Clin Apher. 1997;12:74–81
  7. Lee JH, Leitman SF, Klein HG. A controlled comparison of the efficacy of hetastarch and pentastarch in granulocyte collections by centrifugal leukapheresis. Blood. 1995;86:4662–4666
  8. Price TH, Bowden RA, Boeckh M, et al. Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation. Blood. 2000;95:3302–3309
  9. Leavey PJ, Thurman G, Ambruso DR. Functional characteristics of neutrophils collected and stored after administration of G-CSF. Transfusion. 2000;40:414–419
  10. Dutcher JP, Schiffer CA, Johnston GS, et al. Alloimmunization prevents the migration of transfused indium-111-labeled granulocytes to sites of infection. Blood. 1983;62:354–360
  11. McCullough J, Weiblen BJ, Clay ME, Forstrom L. Effect of leukocyte antibodies on the fate in vivo of indium-111-labeled granulocytes. Blood. 1981;58:164–170
  12. Vamvakas EC, Pineda AA. Meta-analysis of clinical studies of the efficacy of granulocyte transfusions in the treatment of bacterial sepsis. J Clin Apheresis. 1996;11:1–9
  13. Strauss RG. Rebirth of granulocyte transfusions: should it involve pediatric oncology and transplant patients?. J Pediatr Hematol Oncol. 1999;21:475–478[Review] [19 refs]
  14. Mohan P, Brocklehurst P. Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia. Cochrane Database Syst Rev. 2003;CD003956
  15. Stanworth SJ, Massey E, Hyde C, et al. Granulocyte transfusions for treating infections in patients with neutropenia or neutrophil dysfunction. Cochrane Database Syst Rev. 2005;CD005339
  16. Popovsky MA, Moore SB. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion. 1985;25:573–577
  17. Aksu G, Ruhi MZ, Akan H, et al. Aerobic bacterial and fungal infections in peripheral blood stem cell transplants. Bone Marrow Transplant. 2001;27:201–205
  18. Gaytan-Martinez J, Mateos-Garcia E, Sanchez-Cortes E, et al. Microbiological findings in febrile neutropenia. Arch Med Res. 2000;31:388–392
  19. Haupt R, Romanengo M, Fears T, Viscoli C, Castagnola E. Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution. Eur J Cancer. 2001;37:2413–2419
  20. Hughes WT, Armstrong D, Bodey GP, et al. 2002 guidelines for the use of antimicrobial agents in neutropaenic patients with cancer. Clin Infect Dis. 2002;34:730–751
  21. Leavey PJ, Sellins KS, Thurman G, et al. In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro. Blood. 1998;92:4366–4374
  22. Maianski NA, Mul FP, van Buul JD, Roos D, Kuijpers TW. Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils. Blood. 2002;99:672–679
  23. Bennett CL, Evens AM, Andritsos LA, et al. Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project. Br J Haematol. 2006;135:642–650
  24. Glasziou P, Vandenbroucke JP, Chalmers I. Assessing the quality of research. BMJ. 2004;328:39–41
  25. Vandenbroucke JP. Case reports of suspected adverse drug reactions: case reports were dismissed too quickly. BMJ. 2006;332:488
  26. Ippolito RJ, Seashore JH, Touloukian RJ. Excision of pulmonary and renal aspergillomas. Its use in treating chronic granulomatous disease of childhood. Arch Surg. 1978;113:640–642
  27. Pedersen FK, Johansen KS, Rosenkvist J, Tygstrup I, Valerius NH. Refractory Pneumocystis carinii infection in chronic granulomatous disease: successful treatment with granulocytes. Pediatrics. 1979;64:935–938
  28. Chusid MJ, Shea ML, Sarff LD. Determination of posttransfusion granulocyte kinetics by chemiluminescence in chronic granulomatous disease. J Lab Clin Med. 1980;95:168–174
  29. Cohen MS, Isturiz RE, Malech HL, et al. Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med. 1981;71:59–66
  30. Yomtovian R, Abramson J, Quie P, McCullough J. Granulocyte transfusion therapy in chronic granulomatous disease. Report of a patient and review of the literature. Transfusion. 1981;21:739–743
  31. Pole JG, Davie M, Kershaw I, Barter DA, Willoughby ML. Granulocyte transfusion in treatment of infected neutropaenic children. Arch Dis Child. 1976;51:521–527
  32. Schmitz-Valckenberg M, Borberg H. [Therapy with granulocyte transfusions] [German]. Dtsch Med Wochenschr. 1976;101:1458–1460
  33. Alavi JB, Root RK, Djerassi I, et al. A randomized clinical trial of granulocyte transfusions for infection in acute leukemia. N Engl J Med. 1977;296:706–711
  34. Rosen RC, Huestis DW, Corrigan JJ. Acute leukemia and granulocyte transfusion: fatal graft-versus-host reaction following transfusion of cells obtained from normal donors. J Pediatr. 1978;93:268–270
  35. Berkman EM, Eisenstaedt RS, Caplan SN. Supportive granulocyte transfusion in the infected severely neutropaenic patient. Transfusion. 1978;18:693–700
  36. Fernandez MN, Barbolla L, Sanjuan I, et al. [Considerations on the use of granulocytes obtained by intermittent flow centrifugation [IFC] in the transfusion to granulocytopenic patients (author’s transl)] [Spanish]. Sangre (Barc). 1979;24:878–895
  37. Pflieger H, Arnold R, Bhaduri S, et al. Beneficial effect of granulocyte transfusions in patients with defects in granulocyte function and severe infections. Scand J Haematol. 1979;22:33–41
  38. Estes SA, Hendricks AA, Merz WG, Prystowsky SD. Primary cutaneous aspergillosis. J Am Acad Dermatol. 1980;3:397–400
  39. Ritchey AK, Andiman W, McIntosh S, Berman B, Luce D. Mononucleosis syndrome following granulocyte transfusion in patients with leukemia. J Pediatr. 1980;97:267–269
  40. Dana BW, Durie BG, White RF, Huestis DW. Concomitant administration of granulocyte transfusions and amphotericin B in neutropaenic patients: absence of significant pulmonary toxicity. Blood. 1981;57:90–94
  41. Pflieger H, Wiesneth M, Arnold R, Niethammer D, Kleihauer E. Granulocyte transfusions in children. Eur J Pediatr. 1981;135:261–266
  42. Graubner M, Kretschmer V, Loffler H, Mueller-Eckhardt C, Pralle H. [Indications and clinical aspects of granulocyte transfusions (author’s transl)] [German]. Dtsch Med Wochenschr. 1981;106:1726–1732
  43. Kulkarni R, Murray DL, Gupta S, de Mendonca WC, Leader I. Multiple splenic aspergillomas in a patient with acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1982;4:141–145
  44. Winton EF, Moffitt S, Vogler WR, et al. Influence of quantity of granulocytes transfused on response. Prog Clin Biol Res. 1982;88:75–91
  45. Schmidmeier W, Feil W, Gebhart W, et al. Fatal graft-versus-host reaction following granulocyte transfusions. Blut. 1982;45:115–119
  46. Fanconi S, Seger R, Gmur J, et al. Surgery and granulocyte transfusions for life-threatening infections in chronic granulomatous disease. Helv Paediatr Acta. 1985;40:277–284
  47. Depalma L, Leitman SF, Carter CS, Gallin JI. Granulocyte transfusion therapy in a child with chronic granulomatous disease and multiple red cell alloantibodies. Transfusion. 1989;29:421–423
  48. Drakos PE, Nagler A, Or R, et al. Invasive fungal sinusitis in patients undergoing bone marrow transplantation [Review] [31 refs]. Bone Marrow Transplant. 1993;12:203–208
  49. Lekstrom-Himes JA, Holland SM, DeCarlo ES, et al. Treatment with intralesional granulocyte instillations and interferon-gamma for a patient with chronic granulomatous disease and multiple hepatic abscesses. Clin Infect Dis. 1994;19:770–773
  50. Stroncek DF, Leonard K, Eiber G, et al. Alloimmunization after granulocyte transfusions. Transfusion. 1996;36:1009–1015
  51. von PM, Ozsahin H, Schroten H, Stauffer UG, Seger RA. Greater omentum flaps and granulocyte transfusions as combined therapy of liver abscess in chronic granulomatous disease. Eur J Pediatr Surg. 1997;7:234–236
  52. Ozsahin H, von PM, Muller I, et al. Successful treatment of invasive aspergillosis in chronic granulomatous disease by bone marrow transplantation, granulocyte colony-stimulating factor-mobilized granulocytes, and liposomal amphotericin-B. Blood. 1998;92:2719–2724
  53. van ’t Hek LG, Verweij PE, Weemaes CM, et al. Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease. Am J Respir Crit Care Med. 1998;157:1694–1696
  54. Girmenia C, Iori AP, Boecklin F, et al. Fusarium infections in patients with severe aplastic anemia: review and implications for management [Review] [17 refs]. Haematologica. 1999;84:114–118
  55. Notarangelo LD, Casa C, Ferrari E, et al. Resolution of pulmonary and vertebral aspergillosis in a child with CGD following combined use of granulocyte transfusions and voriconazole. ICAAC Abstract Book. 2000;786
  56. Ikinciogullari A, Dogu F, Solaz N, et al. Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. Ther Apher Dial. 2005;9:137–141
  57. Saarinen UM, Hovi L, Vilinikka L, Juvonen E, Myllyla G. Reemphasis on leukocyte transfusions – induction of myeloid marrow recovery in critically ill neutropaenic children with cancer. Vox Sang. 1995;68:90–99
  58. Parco S, Bruno G, Durighello M, et al. Granulocyte transfusion in leukopenic children by simplified leukapheresis of related donors. Int J Artif Organs. 1998;21:63–64
  59. de Montalembert M et al. Granulocyte transfusion in children. Basic science and clinical practice in blood transfusion, 131b. 1-1-1998. Ref Type: Generic.
  60. Grigull L, Schrauder A, Schmitt-Thomssen A, Sykora K, Welte K. Efficacy and safety of G-CSF mobilized granulocyte transfusions in four neutropaenic children with sepsis and invasive fungal infection. Infection. 2002;30:267–271
  61. Lemau DT, Benomar D, Boulat C, Beaumont J-L. Current data on granulocyte donations. Transfus Clin Biol. 2004;11:106–112
  62. Sharon RF, Bierings M, Vrielink H, Versluys B, Boelens JJ. Pre-emptive granulocyte transfusions enable allogeneic hematopoietic stem cell transplantation in pediatric patients with chronic infections. Bone Marrow Transplant. 2006;37:331–333
  63. Yamada T. Critical analysis of granulocyte transfusion in three different methods [filtration leukapheresis (FL), intermittent flow centrifugation (IFC) and continuous flow centrifugation (CFC)]. 2 Clinical efficacies. Shikoku Acta Med. 1984;40:705–715
  64. Sciorelli GA, Ravagnani F, Pellegris G. Granulocyte transfusion therapy. Int J Artif Organs. 1984;7:353–356
  65. Dutcher JP, Kendall J, Norris D, et al. Granulocyte transfusion therapy and amphotericin B: adverse reactions?. Am J Hematol. 1989;31:102–108
  66. Engelhard D, Aker M, Or R, Shinar E. Combined therapy with granulocyte transfusion, intravenous opsonins and antibiotics for overwhelming Pseudomonas aeruginosa septicemia in neutropaenic cancer patients. Pediatr Infect Dis J. 1989;8:332–334
  67. Barrios NJ, Kirkpatrick DV, Murciano A, et al. Successful treatment of disseminated Fusarium infection in an immunocompromised child. [Review] [34 refs]. Am J Pediatr Hematol Oncol. 1990;12:319–324
  68. Angel C, Patrick CC, Lobe T, Rao B, Pui CH. Management of anorectal perineal infections caused by Pseudomonas aeruginosa in children with malignant diseases. J Pediatr Surg. 1991;26:487–493
  69. Duncan BW, Adzick NS, deLorimier AA, et al. Necrotizing fasciitis in two children with acute lymphoblastic leukemia. J Pediatr Surg. 1992;27:668–671
  70. Morrison VA, Weisdorf DJ. Alternaria: a sinonasal pathogen of immunocompromised hosts. Clin Infect Dis. 1993;16:265–270
  71. Bhatia S, McCullough J, Perry EH, et al. Granulocyte transfusions: efficacy in treating fungal infections in neutropaenic patients following bone marrow transplantation. Transfusion. 1994;34:226–232
  72. Rabodonirina M, Piens MA, Monier MF, et al. Fusarium infections in immunocompromised patients: case reports and literature review. Eur J Clin Microbiol Infect Dis. 1994;13:152–161
  73. Murphy JJ, Granger R, Blair GK, et al. Necrotizing fasciitis in childhood. J Pediatr Surg. 1995;30:1131–1134
  74. De Silvestro G, Marson P, Varotto S, et al. Granulocyte concentrates: new findings. Trasfusione del Sangue. 1997;42:295–298
  75. Bielorai B, Neumann Y, Avigad I, et al. Successful treatment of vancomycin-resistant Enterococcus sepsis in a neutropaenic patient with G-CSF-mobilized granulocyte transfusions. Med Pediatr Oncol. 2000;34:221–223
  76. Lee JJ, Chung IJ, Park MR, et al. Clinical efficacy of granulocyte transfusion therapy in patients with neutropenia-related infections. Leukemia. 2001;15:203–207
  77. Johnston DL, Waldhausen JHT, Park JR. Deep soft tissue infections in the neutropaenic pediatric oncology patient. J Pediatr Hematol Oncol. 2001;23:443–447
  78. Illerhaus G, Wirth K, Dwenger A, et al. Treatment and prophylaxis of severe infections in neutropaenic patients by granulocyte transfusions. Ann Hematol. 2002;81:273–281
  79. Vij R, DiPersio JF, Venkatraman P, et al. Donor CMV serostatus has no impact on CMV viremia or disease when prophylactic granulocyte transfusions are given following allogeneic peripheral blood stem cell transplantation [see comment]. Blood. 2003;101:2067–2069
  80. Cesaro S, Chinello P, De Silvestro G, et al. Granulocyte transfusions from G-CSF-stimulated donors for the treatment of severe infections in neutropaenic pediatric patients with onco-hematological diseases. Support Care Cancer. 2003;11:101–106
  81. Lin YW, Adachi S, Watanabe K, Umeda K, Nakahata T. Serial granulocyte transfusions as a treatment for sepsis due to multidrug-resistant Pseudomonas aeruginosa in a neutropaenic patient. J Clin Microbiol. 2003;41:4892–4893
  82. Lee J-J, Song H-C, Chung I-J, et al. Clinical efficacy and prediction of response to granulocyte transfusion therapy for patients with neutropenia-related infections. Haematologica. 2004;89:632–633
  83. Yoshihara T, Ishida H, Morimoto A, et al. Granulocyte transfusions for severe infections prior to allogeneic hematopoietic stem cell transplantation. Rinsho Ketsueki. 2004;45:557–561
  84. Meyer-Koenig U, Hufert FT, Duffner U, Neumann-Haefelin D, Henschen M. G-CSF-mobilised granulocyte transfusion to an ALL patient complicated by cytomegalovirus transmission. Bone Marrow Transplant. 2004;34:1095–1096
  85. Ansari M, Ozsahin H, Gervaix A, Wacker P, Taylor S. Cutaneous aspergillosis in a child with an acute lymphoblastic leukemia. Pediatr Blood Cancer. 2005;45:1005–1006
  86. Grigull L, Beilken A, Schmid H, et al. Secondary prophylaxis of invasive fungal infections with combination antifungal therapy and G-CSF-mobilized granulocyte transfusions in three children with hematological malignancies. Support Care Cancer. 2006;14:783–786
  87. Grigull L, Pulver N, Goudeva L, et al. G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropaenic sepsis. Support Care Cancer. 2006;14:910–916
  88. Kikuta A, Ohto H, Nemoto K, et al. Therapeutic transfusions of granulocytes collected by simple bag method for children with cancer and neutropaenic infections: results of a single-centre pilot study. Vox Sang. 2006;91:70–76
  89. Sachs UJ, Reiter A, Walter T, Bein G, Woessmann W. Safety and efficacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections. Transfusion. 2006;46:1909–1914

PII: S0959-8049(07)00557-6

doi: 10.1016/j.ejca.2007.07.018

European Journal of Cancer
Volume 43, Issue 14 , Pages 2082-2092 , September 2007

Article Tools

* Image Usage & Resolution