European Journal of Cancer
Volume 45, Issue 1 , Pages 99-106 , January 2009

Renal function after ifosfamide, carboplatin and etoposide (ICE) chemotherapy, nephrectomy and radiotherapy in children with wilms tumour

  • Najat C. Daw

      Affiliations

    • Department of Oncology, Mail Stop 260, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, TN 38105-3678, USA
    • Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    • Corresponding Author InformationCorresponding author: Address: Department of Oncology, Mail Stop 260, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, TN 38105-3678, USA. Tel.: +1 901 595 2573; fax: +1 901 521 9005.
    • ,
  • David Gregornik

      Affiliations

    • Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
    • ,
  • John Rodman

      Affiliations

    • Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
    • Deceased.
    • ,
  • Neyssa Marina

      Affiliations

    • Department of Oncology, Mail Stop 260, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, TN 38105-3678, USA
    • Present address: Pediatric Hematology/Oncology, Stanford University Medical Center, Palo Alto, California, USA.
    • ,
  • Jianrong Wu

      Affiliations

    • Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
    • ,
  • Larry E. Kun

      Affiliations

    • Department of Radiological Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
    • ,
  • Jesse J. Jenkins

      Affiliations

    • Department of Pathology and Laboratory Medicine, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
    • ,
  • Valerie McPherson

      Affiliations

    • Department of Oncology, Mail Stop 260, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, TN 38105-3678, USA
    • ,
  • Judith Wilimas

      Affiliations

    • Department of Oncology, Mail Stop 260, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, TN 38105-3678, USA
    • ,
  • Deborah P. Jones

      Affiliations

    • Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    • Children’s Foundation Research Center at LeBonheur Children’s Medical Center, Memphis, Tennessee, USA

Received 4 July 2008 ,Revised 26 August 2008 ,Accepted 25 September 2008.

  • Image Result

    Therapy schema. V=vincristine 1.5mg/m2 (maximum dose, 2mg); D=dactinomycin 0.6mg/m2 (maximum dose, 2mg); A=doxorubicin (Adriamycin) 25mg/m2; ICE chemotherapy: C=carboplatin, dosage based on GFR to tar

    Therapy schema. V=vincristine 1.5mg/m2 (maximum dose, 2mg); D=dactinomycin 0.6mg/m2 (maximum dose, 2mg); A=doxorubicin (Adriamycin) 25mg/m2; ICE chemotherapy: C=carboplatin, dosage based on GFR to target an AUC of 6mg/mlmin on day 1; E=etoposide 100mg/m2 per day on days 2–4; I=ifosfamide 2g/m2 per day on days 2–4.

  • Image Result
    Bland–Altman plot to assess agreement between GFR and estimated creatinine clearance (n=35 pairs). The solid line represents the bias of the difference between pairs (17.8ml/min per 1.73m2) and the da

    Bland–Altman plot to assess agreement between GFR and estimated creatinine clearance (n=35 pairs). The solid line represents the bias of the difference between pairs (17.8ml/min per 1.73m2) and the dashed lines represent the 95% confidence interval.

  • Image Result
    Renal tubular function was longitudinally assessed by measuring urinary magnesium excretion (a), renal tubular threshold for phosphate (b), and urinary β2-microglobulin (c) in patients with Wilms tumo

    Renal tubular function was longitudinally assessed by measuring urinary magnesium excretion (a), renal tubular threshold for phosphate (b), and urinary β2-microglobulin (c) in patients with Wilms tumour treated with ICE. Shaded areas (a,b) represent the normal range.

PII: S0959-8049(08)00749-1

doi: 10.1016/j.ejca.2008.09.017

European Journal of Cancer
Volume 45, Issue 1 , Pages 99-106 , January 2009

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