European Journal of Cancer
Volume 46, Issue 2 , Pages 430-438 , January 2010

Telomere lengths in the oral epithelia with and without carcinoma

  • Junko Aida

      Affiliations

    • Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
    • Corresponding Author InformationCorresponding author: Tel.: +81 3 3964 3241; fax: +81 3 3579 4776.
    • ,
  • Toshiyuki Izumo

      Affiliations

    • Department of Pathology, Saitama Cancer Center, Saitama Prefecture 362-0806, Japan
    • ,
  • Naotaka Shimomura

      Affiliations

    • Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
    • ,
  • Ken-ichi Nakamura

      Affiliations

    • Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
    • ,
  • Naoshi Ishikawa

      Affiliations

    • Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
    • ,
  • Masaaki Matsuura

      Affiliations

    • Department of Cancer Genomics, The Cancer Institute, The Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
    • ,
  • Steven S. Poon

      Affiliations

    • Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada V5Z 1L3
    • ,
  • Mutsunori Fujiwara

      Affiliations

    • Department of Pathology, Japanese Red Cross Medical Center, Tokyo 150-8935, Japan
    • ,
  • Motoji Sawabe

      Affiliations

    • Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan
    • ,
  • Tomio Arai

      Affiliations

    • Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan
    • ,
  • Kaiyo Takubo

      Affiliations

    • Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan

Received 2 September 2009 ,Revised 9 October 2009 ,Accepted 15 October 2009.

References 

  1. Londono-Vallejo JA. Telomere instability and cancer. Biochimie. 2008;90(1):73–82
  2. Sciubba JJ. Oral cancer. The importance of early diagnosis and treatment. Am J Clin Dermatol. 2001;2(4):239–251
  3. Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH. A genetic explanation of Slaughter’s concept of field cancerization: evidence and clinical implications. Cancer Res. 2003;63(8):1727–1730
  4. Takubo K, Izumiyama-Shimomura N, Honma N, et al. Telomere lengths are characteristic in each human individual. Exp Gerontol. 2002;37(4):523–531
  5. Nakamura K, Takubo K, Izumiyama-Shimomura N, et al. Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older. Exp Gerontol. 2007;42(10):944–950
  6. Ishii A, Nakamura K, Kishimoto H, et al. Telomere shortening with aging in the human pancreas. Exp Gerontol. 2006;41(9):882–886
  7. Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol. 2007;38(8):1192–1200
  8. Kurabayashi R, Takubo K, Aida J, et al. Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol. 2008;39:1647–1655
  9. Shiraishi H, Mikami T, Aida J, et al. Telomere shortening in Barrett’s mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity. Scand J Gastroenterol. 2009;44(5):538–544
  10. Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol. 2008;43(9):833–839
  11. Nakamura K, Izumiyama-Shimomura N, Sawabe M, et al. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium. J Invest Dermatol. 2002;119(5):1014–1019
  12. Meeker AK, Hicks JL, Iacobuzio-Donahue CA, et al. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004;10(10):3317–3326
  13. Gisselsson D, Jonson T, Petersen A, et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA. 2001;98(22):12683–12688
  14. O’Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32(2):280–284
  15. Montgomery E, Wilentz RE, Argani P, et al. Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies. Cancer Biol Ther. 2003;2(3):248–252
  16. Ohashi M, Aizawa S, Ooka H, et al. A new human diploid cell strain, TIG-1, for the research on cellular aging. Exp Gerontol. 1980;15(2):121–133
  17. van Heek NT, Meeker AK, Kern SE, et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol. 2002;161(5):1541–1547
  18. Satyanarayana A, Manns MP, Rudolph KL. Telomeres and telomerase: a dual role in hepatocarcinogenesis. Hepatology. 2004;40(2):276–283
  19. Nakajima T, Moriguchi M, Katagishi T, et al. Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD. Liver Int. 2006;26(1):23–31

PII: S0959-8049(09)00776-X

doi: 10.1016/j.ejca.2009.10.018

European Journal of Cancer
Volume 46, Issue 2 , Pages 430-438 , January 2010

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