European Journal of Cancer
Volume 33, Issue 5 , Pages 703-709 , April 1997

The biology of replicative senescence

References 

  1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614–636
  2. Stanulis-Praeger B. Cellular senescence revisited: a review. Mech Ageing Dev. 1987;38:1–48
  3. Campisi J, Dimri GP, Hara E. Control of replicative senescence. In: Schneider E, Rowe J editor. Handbook of the Biology of Aging. New York: Academic Press; 1996;p. 121–149
  4. Campisi J. Replicative senescence: an old lives tale?. Cell. 1996;84:497–500
  5. Jazwinski SM. The genetics of aging in the yeast Saccharomyces cerevisiae. Genetica. 1993;91:35–51
  6. Sager R. Senescence as a mode of tumor suppression. Environ Health Persp. 1991;93:59–62
  7. McCormick JJ, Maher VM. Towards an understanding of the malignant transformation of diploid human fibroblasts. Mutat Res. 1988;199:273–291
  8. Shay JW, Wright WE. Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta. 1991;1071:1–7
  9. Pereira-Smith OM, Smith JR. Evidence for the recessive nature of cellular immortality. Science. 1983;221:964–967
  10. Pereira-Smith OM, Smith JR. Genetic analysis of indefinite division in human cells: identification of four complementation groups. In: Proc Natl Acad Sci USA. 85:1988;p. 6042–6046
  11. Ning Y, Weber JL, Killary AM, Ledbetter DH, Smith JR, Pereira-Smith OM. Genetic analysis of indefinite division in human cells: evidence for a senescencerelated gene (s) on human chromosome 4. In: Proc Natl Acad Sci USA. 88:1991;p. 5635–5639
  12. Hensler P, Annab LA, Barrett JC, Pereira-Smith OM. A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol. 1994;14:2292–2297
  13. Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M. Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol. 1993;13:6036–6043
  14. Goldstein S. Replicative senescence: the human fibroblast comes of age. Science. 1990;249:1129–1133
  15. Rittling SR, Brooks KM, Cristofalo VJ, Baserga R. Expression of cell cycle dependent genes in young and senescent WI38 fibroblasts. In: Proc Natl Acad Sci USA. 83:1986;p. 3316–3320
  16. Seshadri T, Campisi J. cfos repression and an altered genetic program in senescent human fibroblasts. Science. 1990;247:205–209
  17. Hara E, Yamaguchi T, Nojima H, et al. Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J Biol Chem. 1994;269:2139–2145
  18. Dimri GP, Hara E, Campisi J. Regulation of two E2F related genes in presenescent and senescent human fibroblasts. J Biol Chem. 1994;269:16180–16186
  19. Good LF, Dimri GP, Campisi J, Chen KY. Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J Cell Physiol. 1996;168:580–588
  20. Stein GH, Beeson M, Gordon L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science. 1990;249:666–669
  21. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res. 1994;211:90–98
  22. Hara E, Smith R, Parry D, Tahara H, Peters G. Regulation of p16 (CdkN2) expression and its implications for cell immortalization and senescence. Mol Cell Biol. 1996;16:859–867
  23. Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-cdk and cyclin D-cdk complexes. In: Proc Natl Acad Sci USA. 90:1993;p. 11034–11038
  24. Dimri GP, Nakanishi M, Desprez PY, Smith JR, Campisi J. Inhibition of E2F activity by the p21 inhibitor of cyclindependent protein kinases in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol. 1996;16:2987–2997
  25. Hara E, Uzman JA, Dimri GP, Nehlin JO, Testori A, Campisi J. The helixloop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. Dev Genetics. 1996;18:161–172
  26. Wang E. Senescent human fibroblasts resist programmed cell death and failure to suppress bcl2 is involved. Cancer Res. 1995;55:2284–2292
  27. Linskens M, Harley CB, West MD, Campisi J, Hayflick L. Replicative senescence and cell death. Science. 1995;267:17
  28. Maier JAM, Voulalas P, Roeder D, Maciag T. Extension of the lifespan of human endothelial cells by an interleukin-1α antisense oligomer. Science. 1990;249:1570–1574
  29. Maier JAM, Statuto M, Ragnoti G. Senescence stimulates U037-endothelial cell interactions. Exp Cell Res. 1993;208:270–274
  30. Swisshelm K, Ryan K, Lee X, Tsou H, Peacocke M, Sager R. Downregulation of retinoic acid receptor β in mammary carcinoma cell lines and its upregulation in senescing normal mammary epithelial cells. Cell Growth Diff. 1994;5:133–141
  31. West MD, Pereira-Smith OM, Smith JR. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp Cell Res. 1989;184:138–139
  32. Millis AJ, Hoyle M, McCue HM, Martini H. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp Cell Res. 1992;201:373–379
  33. Wick M, Burger C, Brusselbach S, Lucibello FC, Muller R. A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation and senescence. J Biol Chem. 1994;269:18953–18960
  34. Finch CE. In: Longevity, Senescence and the Genome. Chicago, Illinois: University of Chicago Press; 1990;
  35. Dimri GP, Lee X, Basile G, et al. A novel biomarker identifies senescent human cells in culture and aging skin in vivo. In: Proc Natl Acad Sci USA. 92:1995;p. 9363–9367
  36. Campisi J. Aging and cancer: the double-edged sword of replicative senescence. J Am Geriatrics Soc. 1997;45:1–6
  37. Harley CB, Villeponteau B. Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev. 1995;5:249–255
  38. Hara E, Tsuri H, Shinozaki S, Oda K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1. Biochem Biophys Res Comm. 1991;179:528–534
  39. Shay JW, Wright WE, Brasiskyte D, Vanderhaegen BA. E6 of human papillomavirus type-16 can overcome the M1 stage immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene. 1993;8:1407–1413
  40. Wazer DE, Liu XL, Chu Q, Gao Q, Band V. Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. In: Proc Natl Acad Sci USA. 92:1995;p. 3687–3691
  41. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB. Telomere endreplication problem and cell aging. J Mol Biol. 1992;225:951–960
  42. Tommerup H, Dousmanis A, De Lange T. Unusual chromatin in human telomeres. Mol Cell Biol. 1994;14:5777–5785
  43. Blackburn EH. Structure and function of telomeres. Nature. 1991;350:569–573
  44. Blackburn EH. Telomerases. Ann Rev Biochem. 1992;61:113–129
  45. Allshire RC, Dempster M, Hastie ND. Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res. 1989;17:4611–4627
  46. Harley CB, Futcher AB, Greider CW. Telomeres shorten during aging of human fibroblasts. Nature. 1990;345:458–460
  47. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with aging. Nature. 1990;346:866–868
  48. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ. In vivo loss of telomeric repeats with age in humans. Mutat Res. 1991;256:45–48
  49. Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts. In: Proc Natl Acad Sci USA. 89:1992;p. 10114–10118
  50. Allsopp RC, Harley CB. Evidence for a critical telomere length in senescent human fibroblasts. Exp Cell Res. 1995;219:130–136
  51. Wright WE, Brasiskyte D, Piatyszek M, Shay JW. Experimental elongation of telomeres extends the lifespan of immortal × normal cell hybrids. EMBO J. 1996;15:1734–1741
  52. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;226:2011–2015
  53. Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood. 1995;85:2315–2320
  54. Hiyama K, Hirai Y, Kyoisumi S, et al. Telomerase activity in human peripheral blood and bone marrow cells. J Immunol. 1995;155:3711–3715
  55. Landsdorp PM. Telomere length and proliferation potential of hematopoietic stem cells. J Cell Sci. 1995;108:1–6
  56. Prowse KR, Greider CW. Development and tissue specific regulation of mouse telomerase and telomere length. In: Proc Natl Acad Sci USA. 92:1995;p. 4818–4822
  57. Broccoli D, Young JW, DeLange T. Telomerase activity in normal and malignant hematopoietic cells. In: Proc Natl Acad Sci USA. 93:1995;p. 9083–9086
  58. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genetics. 1996;18:173–179
  59. Vaziri H, Schachter F, Uchida I, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet. 1993;52:661–667
  60. Buchkovich KJ, Greider CW. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Cell Biol. 1996;7:1443–1454
  61. Effros RB. Insights on immunological aging derived from the T lymphocyte cellular senescence model. Exp Gerontol. 1996;31:21–27
  62. Weng NP, Levine BL, June CH, Hodes RJ. Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med. 1996;183:2471–2479
  63. Harlebachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and immortal and carcinomaderived skin keratinocytes. In: Proc Natl Acad Sci. 93:1996;p. 6476–6481
  64. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 1995;14:4240–4248
  65. Strahl C, Blackburn EH. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol. 1996;16:53–65
  66. Wright WE, Shay JW. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?. Trends Cell Biol. 1995;5:293–297
  67. Sandell LL, Zakian VA. Loss of a yeast telomere: arrest, recovery and chromosome loss. Cell. 1993;75:729–739
  68. Afshari CA, Vojta PJ, Annab LA, Futreal PA, Willard TB, Barrett JC. Investigation of the role of G1/S cell cycle mediators in cellular senescence. Exp Cell Res. 1993;209:231–237
  69. Oshima J, Campisi J, Tannock CA, Martin GM. Regulation of c-fos in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol. 1995;162:277–283
  70. Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol. 1989;9:3088–3092
  71. Radna RL, Caton Y, Jha KK, et al. Growth of immortal simian virus 40 ts-A transformed human fibroblasts is temperature dependent. Mol Cell Biol. 1989;9:3093–3096
  72. Marcand S, Buck SW, Moretti P, Gilson E, Shore D. Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes Dev. 1996;10:1297–1309
  73. Shay JW, Werbin H, Wright WE. You haven't heard the end of it: telomere loss may link human aging with cancer. Can J Aging. 1995;14:511–524
  74. Wright WE, Shay JW. Telomere positional effects and the regulation of cellular senescence. Trends Genet. 1992;8:193–197
  75. Laurenson P, Rine J. Silencers, silencing and heritable transcriptional states. Microbiol Rev. 1992;56:543–560
  76. Shore D. Telomere position effect and transcriptional silencing in the yeast Saccharomyces cerevisiae. In: Blackburn EH, Greider CW editor. Telomeres. Cold Spring Harbor Press; 1995;p. 247–263
  77. Ogryzko W, Harai TH, Russanova VR, Barbie DA, Howard BH. Human fibroblast commitment to a senescence-like state in responses to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol. 1996;16:5210–5218
  78. Kim S, Villeponteau B, Jazwinski SM. Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae. Biochem Biophys Res Comm. 1996;219:370–376
  79. Smeal T, Claus J, Kennedy B, Cole F, Guarente L. Loss of transcriptional silencing causes sterility in old mother cells of S cerevisiae. Cell. 1996;84:633–642

PII: S0959-8049(96)00058-5

doi: 10.1016/S0959-8049(96)00058-5

European Journal of Cancer
Volume 33, Issue 5 , Pages 703-709 , April 1997