European Journal of Cancer
Volume 36, Issue 16 , Pages 2076-2082 , October 2000

Germ line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients

  • H Özdag

      Affiliations

    • Department of Molecular Biology and Genetics, Bilkent University, Ankara 06533, Turkey
    • ,
  • M Tez

      Affiliations

    • Department of Surgery, Hacettepe University Medical School, Ankara 06100, Turkey
    • ,
  • I Sayek

      Affiliations

    • Department of Surgery, Hacettepe University Medical School, Ankara 06100, Turkey
    • ,
  • M Müslümanoglu

      Affiliations

    • Department of Surgery, Istanbul University, Istanbul Medical School, Istanbul 34080, Turkey
    • ,
  • O Tarcan

      Affiliations

    • Ankara Oncology Hospital, Ankara 06200, Turkey
    • ,
  • F Içli

      Affiliations

    • Department of Medical Oncology, Ankara University Medical School, Ankara 06100, Turkey
    • ,
  • M Öztürk

      Affiliations

    • Department of Molecular Biology and Genetics, Bilkent University, Ankara 06533, Turkey
    • ,
  • T Özçelik

      Affiliations

    • Department of Molecular Biology and Genetics, Bilkent University, Ankara 06533, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 312 266 5081; fax: +90 312 266 5097

Received 25 January 2000 ,Revised 15 May 2000 ,Accepted 23 June 2000.

References 

  1. Miki Y, Swensen J, Shattuck-Eidens D, et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266:66–71
  2. Thorlacius S, Struewing JP, Hartge P, et al.  Population-based study of risk of breast cancer in carriers of BRCA2 mutation. Lancet. 1998;352:1337–1339
  3. Feunteun J. La predisposition hereditaire au cancer du sein liee a BRCA1 et BRCA2 (une maladie de la reponse aux lesions genotoxiques). Medicine et Sciences. 1999;15:38–44
  4. Easton DF, Bishop DT, Ford D. Genetic linkage analysis in familial breast and ovarian cancer (results form 214 families). Am. J. Hum. Genet. 1993;52:678–701
  5. Wooster R, Bignell G, Lancaster J. Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378:789–792
  6. Szabo CI, King M-C. Population genetics of BRCA1 and BRCA2. Am. J. Hum. Genet. 1997;60:1013–1020
  7. Malone KE, Daling JR, Thompson JD. BRCA1 mutations and breast cancer in the general population. J. Am. Med. Assoc. 1998;279:922–929
  8. Friedman LS, Gayther SA, Kurosaki T. Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population. Am. J. Hum. Genet. 1997;60:313–319
  9. Karaoguz H, Içli F. J. Ankara Med. Sch. 1993;15:547–558
  10. Sambrook J, Fritsch E, Maniatis T. Molecular Cloning. New York: Cold Spring Harbor Laboratory Press; 1989;
  11. Friedman LS, Ostermeyer EA, Szabo CI. Confirmation of BRCA1 by analysis of germ-line mutations linked to breast and ovarian cancer in ten families. Nature Genet. 1994;8:399–404
  12. Lancester JM, Wooster R, Mangion J. BRCA2 mutations in primary breast and ovarian cancers. Nature Genet. 1996;13:238–240
  13. Balcı A, Huusko P, Pääkkönen K. Mutation analysis of BRCA1 and BRCA2 in Turkish cancer families (a novel mutation BRCA2 3414del4 found in male breast cancer). Eur. J. Cancer. 1999;35:707–710
  14. Serova OM, Mazoyer S, Puget N. Mutations in BRCA1 and BRCA2 in breast cancer families (are there more breast cancer-susceptibility genes?). Am. J. Hum. Genet. 1997;60:486–495
  15. Sobol H, Birnbaum D, Eisinger F. Evidence for a third breast-cancer susceptibility gene. Lancet. 1994;344:1151–1152

PII: S0959-8049(00)00277-X

European Journal of Cancer
Volume 36, Issue 16 , Pages 2076-2082 , October 2000

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