European Journal of Cancer
Volume 37, Issue 4 , Pages 499-502 , March 2001

APC I1307K and E1317Q variants are rare or do not occur in Swedish colorectal cancer patients

  • S. Evertsson

      Affiliations

    • Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, S-581 85 Linköping, Sweden
    • ,
  • A. Lindblom

      Affiliations

    • Department of Molecular Medicine, Clinical Genetics Unit,CMM L8-2 Karolinska Institutet, S-171 76 Stockholm, Sweden
    • ,
  • X.-F. Sun

      Affiliations

    • Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, S-581 85 Linköping, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46-13-222-066; fax: +46-13-222-846

Received 5 June 2000 ,Revised 15 September 2000 ,Accepted 1 November 2000.

References 

  1. Miyoshi Y, Nagase H, Ando H, et al.  Somatic mutations of the APC gene in colorectal tumors (mutation cluster region in the APC gene). Mol. Genet. 1992;1:229–233
  2. Laken SJ, Petersen GM, Gruber SB, et al.  Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat. Genet. 1997;17:79–83
  3. Rozen P, Shomrat R, Strul H, et al.  Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer. Gastroenterology. 1999;116:54–57
  4. Woodage T, King SM, Wacholder S, et al.  The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews. Nat. Genet. 1998;20:62–65
  5. Prior TW, Chadwick RB, Papp AC, et al.  The I1307K polymorphism of the APC gene in colorectal cancer. Gastroenterology. 1999;116:58–63
  6. Frayling IM, Beck NE, Ilyas M, et al.  The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. Proc. Natl. Acad. Sci. USA. 1998;95:10722–10727
  7. Lothe RA, Hektoen M, Johnsen H, et al.  The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer. Cancer Res. 1998;58:2923–2924
  8. Nathanson KL, Antin-Ozerkis D, Couch FJ, Weber BL. I1307K APC variant in non-Ashkenazi Jewish women affected with breast cancer. Am. J. Med. Gen. 1999;85:189–190
  9. White S, Bubb VJ, Wyllie AH. Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adenomatous polyposis. Genes Chromosomes Cancer. 1996;15:122–128
  10. Petrukhin L, Dangel JE, Vanderveer L, et al.  The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast–ovarian cancer kindreds. Cancer Res. 1997;57:5480–5484
  11. Ming SC. Gastric carcinoma, a pathobiological classification. Cancer. 1977;39:2475–2485
  12. Morson BC. Colour atlas of gastrointestinal pathology. In:  Curran RC editors. Oxford Colour Atlases of Pathology. Oxford: Oxford University Press; 1998;
  13. Hermanek P. Colorectal carcinoma (histopathological diagnosis and staging). Baillers Clin. Gastroenterol. 1989;3:511–529
  14. Popat S, Stone J, Coleman G, et al.  Prevalence of the APC E1317Q variant in colorectal cancer patients. Cancer Lett. 2000;149:203–206

PII: S0959-8049(00)00393-2

European Journal of Cancer
Volume 37, Issue 4 , Pages 499-502 , March 2001

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