European Journal of Cancer
Volume 37, Issue 18 , Pages 2428-2434 , December 2001

Genetic epidemiology of BRCA1 mutations in Norway

  • P Møller

      Affiliations

    • Section of Genetic Counselling, Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway
    • Corresponding Author InformationCorrespondending author. Tel.: +47-2293-5675; fax: +47-2293-5219
  • ,
  • K Heimdal

      Affiliations

    • Section of Genetic Counselling, Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway
  • ,
  • J Apold

      Affiliations

    • Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
  • ,
  • Å Fredriksen

      Affiliations

    • Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
  • ,
  • Å Borg

      Affiliations

    • Department of Oncology, University Hospital, Lund, Sweden
  • ,
  • E Hovig

      Affiliations

    • Department of Tumour Biology, The Norwegian Radium Hospital, N-0310 Oslo, Norway
  • ,
  • A Hagen

      Affiliations

    • Surgical Department, University Hospital of Trondheim, Norway
  • ,
  • B Hagen

      Affiliations

    • Gynaecological Department, University Hospital of Trondheim, Norway
  • ,
  • J.C Pedersen

      Affiliations

    • Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway
  • ,
  • L Mæhle

      Affiliations

    • Section of Genetic Counselling, Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway
  • ,
  • The Norwegian Inherited Breast Cancer Group, The Norwegian Inherited Ovarian Cancer Group

      Affiliations

    • The list of group members can be found in the Appendix.

Received 8 May 2001 ,Revised 11 July 2001 ,Accepted 20 August 2001.

References 

  1. Broca P. In Traité des Tumeurs. Paris, 1866, 151–155.
  2. Iselius L, Littler M, Morton N. Transmission of breast cancer—a controversy resolved. Clin. Genet. 1992;41:211–217
  3. Hall JM, Lee MK, Newman B, et al.  Linkage of early-onset familial breast cancer to chromosome 17q21. Science. 1990;250:1684–1689
  4. Miki Y, Swensen J, Shattuck-Eidens D, et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266:66–71
  5. Wooster R, Neuhausen SL, Mangion J, et al.  Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science. 1994;265:2088–2090
  6. Wooster R, Bignell G, Lancaster J, et al.  Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378:789–792
  7. Tavtigian SV, Simard J, Rommens J, et al.  The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat. Genet. 1996;12:333–337
  8. Struewing JP, Abeliovich D, Peretz T, et al.  The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals. Nat. Genet. 1995;11:198–200
  9. Andersen TI, Borresen AL, Moller P. A common BRCA1 mutation in Norwegian breast and ovarian cancer families?. Am. J. Hum. Genet. 1996;59:486–487
  10. Dorum A, Moller P, Kamsteeg EJ, et al.  A BRCA1 founder mutation, identified with haplotype analysis, allowing genotype/phenotype determination and predictive testing. Eur. J. Cancer. 1997;33:2390–2392
  11. NOU 1999:20. Norwegian Government, Oslo, Norway, 1999, 79, 89.
  12. Malkin D, Li FP, Strong LC, et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250:1233–1238
  13. Lynch ED, Ostermeyer EA, Lee MK, et al.  Inherited mutations in PTEN that are associated with breast cancer, Cowden disease, and juvenile polyposis. Am. J. Hum. Genet. 1997;61:1254–1260
  14. Anglian Breast Cancer Study Group . Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Br. J. Cancer. 2000;83:1301–1308
  15. Fisher RA. The Genetical Theory of Natural Selection. Dover, New York, USA, 1958, 83, 87.
  16. Apold J, Eiken HG, Fredriksen Å, Bakken A, Lorens JB, Boman H. A termination mutation prevalent in Norwegian haplotype 7 phenylketonuria genes. Am. J. Hum. Genet. 1990;47:1002–1007
  17. Dorum A, Hovig E, Trope C, Inganas M, Moller P. Three per cent of Norwegian ovarian cancers are caused by BRCA1 1675delA or 1135insA. Eur. J. Cancer. 1999;35:779–781
  18. Moller P, Borg A, Heimdal K, et al.  The BRCA1 syndrome and other inherited breast or breast-ovarian cancers in a Norwegian prospective series. Eur. J. Cancer. 2001;37:1027–1032
  19. Moller P. Genetic cancer; a challenge and a possible strategy. J. Cancer Care. 1993;2:94–99
  20. Reichelt JG, Dahl AA, Heimdal K, Moller P. Uptake of genetic testing and pre-test levels of mental distress in Norwegian families with known BRCA1 mutations. Dis. Markers. 1999;15:139–143
  21. Hoff I. Norwegische Mundartforschung. Zeitschrift für Mundartforschung. 1970;6:399–458
  22. Breast Cancer Information Core. http://www.nhgri.nih.gov/intramural_research/Lab_transfer/Bic/index.html.
  23. Hakansson S, Johannsson O, Johansson U, et al.  Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer. Am. J. Hum. Genet. 1997;60:1068–1078
  24. Vehmanen P, Friedman LS, Eerola H, et al.  Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families (evidence for additional susceptibility genes). Hum. Mol. Genet. 1997;6:2309–2315
  25. Johannesdottir G, Gudmundsson J, Bergthorsson JT, et al.  High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients. Cancer Res. 1996;15:3663–3665
  26. Arason A, Jonasdottir A, Barkardottir RB, et al.  A population study of mutations and LOH at breast cancer gene loci in tumours from sister pairs (two recurrent mutations seem to account for all BRCA1/BRCA2 linked breast cancer in Iceland). J. Med. Genet. 1998;35:446–449
  27. Kainu T, Juo SH, Desper R, et al.  Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus. Proc. Natl. Acad. Sci. USA. 2000;97:9603–9608
  28. Heimdal K, Maehle L, Moller P. Costs and benefits of diagnosing familial breast cancer. Dis. Markers. 1999;15:167–173

PII: S0959-8049(01)00299-4

doi: 10.1016/S0959-8049(01)00299-4

European Journal of Cancer
Volume 37, Issue 18 , Pages 2428-2434 , December 2001