European Journal of Cancer
Volume 39, Issue 6 , Pages 728-735, April 2003

Potential role of magnetic resonance spectroscopy in assessment of tumour response in childhood cancer

  • S.J. Vaidya

      Affiliations

    • Department of Paediatric Oncology, Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK
    • ,
  • Geoffrey S. Payne

      Affiliations

    • Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK
    • ,
  • Martin O. Leach

      Affiliations

    • Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK
    • ,
  • C.R. Pinkerton

      Affiliations

    • Department of Paediatric Oncology, Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44-20-8661-3957; fax: +44-20-8661-3617

Received 29 April 2002; received in revised form 25 October 2002; accepted 8 November 2002.

Abstract 

This brief review considers to what extent Magnetic Resonance Spectroscopy (MRS) can play a role in monitoring early tumour response with examples of preclinical studies and selected clinical studies in tumours of children and young adults. An early non-invasive indicator of tumour response to therapy would provide useful information regarding the effectiveness of therapy. This might be a relevant prognostic factor in new patients and in phase II studies could facilitate recommendations at an early stage as to whether to continue treatment. This review suggests that several markers and ratios are emerging as potential prognostic markers, but larger prospective studies are needed before translating this into clinical practice.

Keywords:  MRS, Childhood cancers, Tumour response

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PII: S0959-8049(02)00728-1

doi:10.1016/S0959-8049(02)00728-1

European Journal of Cancer
Volume 39, Issue 6 , Pages 728-735, April 2003

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