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European Journal of Cancer
Volume 39, Issue 6
, Pages 829-837
, April 2003
Study of in vitro and in vivo effects of the piperidine nitroxide Tempol—a potential new therapeutic agent for gliomas
References
-
.
Neoplasms of the central nervous system.
In:
De Vita VT, Hellman S, Rosenberg SA editor. Cancer Principles and Practice of Oncology. Philadelphia: Lippincott; 1993;p. 1697–1737
- . Malignant glioma (should chemotherapy be overthrown by experimental treatments?). Ann. Oncol. 1996;9:589–600
-
.
Antiproliferative effect of the piperidine nitroxide TEMPOL on neoplastic and nonneoplastic mammalian cell lines.
Free Rad. Biol. Med. 1998;24:913–923
-
.
The nitroxide TEMPOL induces oxidative stress, p21 WAF1/CIP1, and cell death in HL60 cells.
Free Rad. Biol. Med. 2000;29:633–641
- Characterization of p53 and p21 functional interactions in glioma cells en route of apoptosis. J. Natl. Cancer Inst. 1997;89:1036–1044
-
.
Mechanism of brain protection by nitroxide radicals in experimental model of closed-head injury.
Free Rad. Biol. Med. 1998;24:332–340
- . Hypoxic mammalian cells radiosensitization by nitric oxide. Cancer Res. 1993;53:5845–5848
- Feasibility of drug screening with panels of human tumour cell lines usin a microculture tetrazolium assay. Cancer Res. 1988;48:589–601
-
United Kingdom Co-Ordinating Committee On Cancer Research (UKCCCR) Guidelines for the welfare of animals in experimental neoplasia [second edition] Br J Cancer 1998, 77, 1–10.
- . Microvessel density in brain tumours. Anticancer Res. 1997;17:4747–4753
-
.
Gene therapy of malignant glioma via inhibition of tumour angiogenesis.
Cancer Metast. Rev. 1996;15:237–240
-
.
Protective effect of the nitroxide Tempol against the cardiotoxicity of adriamycin.
Free Rad. Biol. Med. 1996;21:463–470
- . Cellular sites of H2O2-induced damage and their protection by nitroxides. Biochim. Biophys. Acta. 2001;1525:70–76
- . Nitroxides tempol and tempo induce divergent signal transduction pathways in MDA-MB 231 breast cancer cells. J. Biol. Chem. 1998;273:17871–17878
- . Opposing effects of nitroxide free radicals in Escherichia coli mutants deficient in DNA repair. Biochim. Biophys. Acta. 1996;1305:71–78
- . The pro-oxidative activity of SOD and nitroxide SOD mimics. FASEB J. 2000;14:1215–1223
- . Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21waf1/cip1 mediated by STAT1. Science. 1996;272:719–722
- A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J. Biol. Chem. 1995;270:29386–29391
- . Relationship between expression of p21WAF1/CIP1 and radioresistance in human gliomas. Jpn. J. Cancer Res. 1999;90:638–646
- WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis. Oncogene. 1996;13:1279–1285
- Functional expression of human p21 (WAF1/CIP1) gene in rat glioma cells suppresses tumour growth in vivo and induces radiosensitivity. Biochem. Biophys. Res. Commun. 1997;233:329–335
- 1,25-Dihydroxyvitamin D3 induces programmed cell death in a rat glioma cell line. J. Neurosci. Res. 1996;46:540–550
- . Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells (role of c-jun in drug resistance and cell death). Biochem. Pharmacol. 1998;55:1963–1971
- Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res. 1992;52:1750–1753
- . What is the evidence that tumours are angiogenesis dependent?. J. Natl. Cancer Inst. 1990;82:4–6
- Inhibition of growth of human vascular smooth muscle cells by overexpression of p21 gene through induction of apoptosis. Hypertension. 1998;31:493–498
- Chemotherapy in the treatment of recurrent glioblastoma multiforme (ifosfamide versus temozolomide). J. Cancer Res. Clin. Oncol. 1999;125:411–418
- Temozolomide (a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours). Eur. J. Cancer. 1993;29A:940–942
PII: S0959-8049(02)00742-6
doi: 10.1016/S0959-8049(02)00742-6
© 2003 Elsevier Science Ltd. All rights reserved.
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European Journal of Cancer
Volume 39, Issue 6
, Pages 829-837
, April 2003
