European Journal of Cancer
Volume 38 , Pages S13-S18 , December 2002

ZD0473 treatment in lung cancer: an overview of the clinical trial results

  • J Treat

      Affiliations

    • Fox Chase Temple University Cancer Center, Philadelphia, PA, USA
    • Tel.: +1 215 707 8030; Fax: +1 215 728 3574.
  • ,
  • J Schiller

      Affiliations

    • University of Wisconsin Comprehensive Cancer Center, Madison, WI, USA
  • ,
  • E Quoix

      Affiliations

    • University Hospital Strasbourg, France
  • ,
  • A Mauer

      Affiliations

    • University of Chicago Medical Center, Chicago, IL, USA
  • ,
  • M Edelman

      Affiliations

    • Greenbaum Cancer Center, Baltimore, MD, USA
  • ,
  • M Modiano

      Affiliations

    • Arizona Clinical Research Center, Tucson, AZ, USA
  • ,
  • P Bonomi

      Affiliations

    • Rush-Presybterian-St Luke's Medical Center, Chicago, IL, USA
  • ,
  • R Ramlau

      Affiliations

    • Ordynator Oddzialu Onkologii Wielkopolskie Centrum, Poznan, Poland
  • ,
  • E Lemarie

      Affiliations

    • CHU-Hospital Bretonneau, Tours, France

References 

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  5. Rivera MP. Management of patients with advanced non-small-cell lung cancer. Curr Opin Pulm Med. 2001;7:247–251
  6. Vaporciyan AA, Nesbitt JC, Lee JS, Stevens C, Komaki R, Roth JA. Neoplasms of the thorax. In:  Bast RC,  Kufe DW,  Pollock RE,  Weichselbaum RR,  Holland JF,  Frei E editor. Cancer Medicine. Ontario: BC Dekker Inc; 2000;p. 1227–1292
  7. National Cancer Institute PDQ Statement . Non-small cell lung cancer (PDQ): treatment - health professionals. January 2002;
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  12. Kelland L, Judson I, Koehler M, Stephens T, Roberts D. Preclinical and clinical overview of the novel platinum complex, ZD0473 (cis-amminedichloro[2-methylpyridine]platinum[II]). Lung Cancer. 2000;70: Abst 227
  13. Crino L, Tonato M, Darwish S, et al.  A randomized trial of three cisplatin-containing regimens in advanced non-small-cell lung cancer (NSCLC): a study of the Umbrian Lung Cancer Group. Cancer Chemother Pharmacol. 1990;26:52–56
  14. Sandler AB, Nemunaitis J, Denham C, et al.  Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol. 2000;18:122–130
  15. Wozniak AJ, Crowley JJ, Balcerzak SP, et al.  Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: a Southwest Oncology Group Study. J Clin Oncol. 1998;16:2459–2465
  16. Fossella FV, DeVore R, Kerr RN, et al.  Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 non-small-cell lung cancer study group. J Clin Oncol. 2000;18:2354–2362
  17. Shepherd FA, Dancey J, Ramlay R, et al.  Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol. 2000;18:2095–2103
  18. Shepherd FA, Fossella FV, Lynch T, Armand JP, Rigas JR, Kris MG. Docetaxel (Taxotere) shows survival and quality-of-life benefits in the second-line treatment of non-small cell lung cancer: a review of two phase III trials. Semin Oncol. 2001;28:4–9
  19. von Pawel J, Schiller JH, Sheperd FA, et al.  Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. J Clin Oncol. 1999;17:658–667

PII: S0959-8049(02)80016-8

European Journal of Cancer
Volume 38 , Pages S13-S18 , December 2002