European Journal of Cancer
Volume 39, Issue 13 , Pages 1904-1911, September 2003

Familial relative risk of colorectal cancer: a population-based study

  • N. Andrieu

      Affiliations

    • Inserm EMI00-06, Tour Evry 2, 523 Place des Terrasses de l'Agora, 91034 Evry Cedex, France
    • Sevice de Biostatistiques, Institut Curie, 26 rue d'Ulm, 75231 Paris Cedex 5, France
    • Corresponding Author InformationCorresponding author. Tel.: +33-1-6087-3824; fax: +33-1-6087-3848
    • ,
  • G. Launoy

      Affiliations

    • Registre des tumeurs digestives du Calvados, Faculté de Médecine, CHU de Caen, 14033 Caen, France
    • ,
  • R. Guillois

      Affiliations

    • Inserm EMI00-06, Tour Evry 2, 523 Place des Terrasses de l'Agora, 91034 Evry Cedex, France
    • ,
  • C. Ory-Paoletti

      Affiliations

    • Unité Inserm xu-521, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    • ,
  • M. Gignoux

      Affiliations

    • Registre des tumeurs digestives du Calvados, Faculté de Médecine, CHU de Caen, 14033 Caen, France

Received 13 September 2002; received in revised form 28 February 2003; accepted 24 March 2003.

Abstract 

This study aimed to assess the familial relative risk for colorectal cancer (CRC) and its variation according to age and gender. A population-based family study was carried out in France, from 1993 to 1998, including 761 families. Familial CRC risks were estimated from a cohort analysis of the relatives. No obvious decrease in CRC risk was found with increasing age, except when either the proband, or the relative, were in the youngest age class. The effect of the relatives’ and probands’ ages on the CRC risk differed according to their gender. The cumulative risk of CRC increased at an earlier age in male relatives of probands younger than 60 years of age, than in female relatives. This result suggests that mechanisms specific to females, possibly interacting with genetic factors, explain the difference in the cumulative risks between families with male and female probands.

Keywords:  Colorectal cancer, Family study, Relative risk

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PII: S0959-8049(03)00420-9

doi:10.1016/S0959-8049(03)00420-9

European Journal of Cancer
Volume 39, Issue 13 , Pages 1904-1911, September 2003

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