European Journal of Cancer
Volume 39, Issue 17 , Pages 2470-2486 , November 2003

Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data from 21 randomised trials

  • Neoadjuvant Chemotherapy for Cervical Cancer Meta-analysis Collaboration

      Affiliations

    • Corresponding Author InformationCorresponding author: Jayne Tierney, Meta-analysis Group, MRC Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK. Tel.: +44-20-7670-4720; fax: +44-20-7670-4816
    • All aspects of this systematic review and meta-analysis were carried out under the auspices of the NACCCMA Collaboration. See Section 5 for Collaboration participants.
    • Corresponding Author InformationCorresponding author: Jayne Tierney, Meta-analysis Group, MRC Clinical Trials Unit, 222 Euston Road, London, NW1 2DA, UK. Tel.: +44-20-7670-4720; fax: +44-20-7670-4816
    • j.tierney@ctu.mrc.ac.uk

Received 26 February 2003 ,Accepted 10 March 2003.

References 

  1. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int. J. Cancer. 1993;54:594–606
  2. Benedet J, Odicino F, Maisonneuve P, et al.  Carcinoma of the cervix uteri. I Epidemiol. Biostat. 1998;3:5–34
  3. Eifel PJ, Berek JS, Thigpen JT. Gynecologic Cancers. Section 2. Cancer of the cervix, vagina, vulva. In:  DeVita VT,  Hellman S,  Rosenberg SA editor. Cancer: Principles & Practice of Oncology, Vol. 2. 6th ed.. Philadelphia: Lippincott-Raven; 2001;p. 1526–1556
  4. Green JA, Kirwan JM, Tierney JF, et al.  Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix (a systematic review and meta-analysis). Lancet. 2001;358:781–786
  5. Sardi JE, Giaroli A, Sananes C, et al.  Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix. The final results. Gynecol. Oncol. 1997;67:61–69
  6. Tattersall MHN, Lorvidhaya V, Vootiprux V, et al.  Randomized trial of epirubicin and cisplatin chemotherapy followed by pelvic radiation in locally advanced cervical cancer. J. Clin. Oncol. 1995;13:444–451
  7. Tierney JF, Stewart LA, Parmar MKB. Can the published data tell us about the effectiveness of neoadjuvant chemotherapy for locally advanced cancer of the uterine cervix?. Eur. J. Cancer. 1999;35:406–409
  8. Stewart LA, Clarke MJ  on behalf of the Cochrane Working Party Group on Meta-analysis using Individual Patient Data . Practical methodology of meta-analyses (overviews) using updated individual patient data. Stat. Med. 1995;14:2057–2079
  9. Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. In:  Chalmers I,  Altman DG editor. Systematic Reviews. London: BMJ Publishing Group; 1995;p. 17–36
  10. Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction (an overview of the randomized trials). Prog. Cardiovasc. Dis. 1985;27:335–371
  11. Parmar MKB, Machin D. Survival Analysis: A Practical Approach. Chichester: John Wiley & Sons Ltd; 1995;
  12. Advanced Bladder Cancer Overview Collaboration . Does neo-adjuvant cisplatin-based chemotherapy improve the survival of patients with locally advanced bladder cancer (a meta-analysis of individual patient data from randomised clinical trials). Br. J. Urol. 1995;75:206–213
  13. Kaplan EL, Meier P. Nonparametric estimation from incomplete observation. J. Am. Stat. Assoc. 1958;53:457–481
  14. Lira Puerto V, De la Huerta R, Cortes H, et al.  Cisplatin (CDDP) plus radiotherapy (RT) vs radiotherapy alone in locally advanced cervical cancer. Proc ASCO. 1990;9:A633
  15. Lorvidhaya V, Tonusin A, Sukthomya W, Changwiwit W, Nimmolrat A. Induction chemotherapy and irradiation in advanced carcinoma of the cervix. Gan To Kagaku Ryoho. 1995;22(Suppl. 3):244–251
  16. Kumar L, Grover R, Pokharel YH, et al.  Neoadjuvant chemotherapy in locally advanced cervical cancer (two randomised studies). Aust. N. Z. J. Med. 1998;28:387–390
  17. Sardi J, Giaroli A, Sananes C, et al.  Randomized trial with neoadjuvant chemotherapy in stage IIIB squamous carcinoma cervix uteri (an unexpected therapeutic management). Int J Gynecol Cancer. 1996;6:85–93
  18. Sardi JE, Sananes CE, Giaroli AA, et al.  Neoadjuvant chemotherapy in cervical carcinoma stage IIB (a randomized controlled trial). Int. J. Gynecol. Cancer. 1998;8:441–450
  19. Chauvergne J, Lhomme C, Rohart J, et al.  Chimiothérapie néoadjuvante des cancer du col utérin aux stades IIb e III. Résultats éloignés d'un essai randomisé pluricentrique portant sur 151 patients. Bull. Cancer (Paris). 1993;80:1069–1079
  20. Souhami L, Gil RA, Allan SE, et al.  A randomized trial of chemotherapy followed by pelvic radiation therapy in stage IIIB carcinoma of the cervix. J. Clin. Oncol. 1991;9:970–977
  21. Herod J, Burton A, Bixton J, et al.  A randomised prospective phase III clinical trial of primary bleomycin, ifosfamide and cisplatin (BIP) chemotherapy followed by radiotherapy versus radiotherapy alone in operable cancer of the cervix. Ann. Oncol. 2000;11:1175–1181
  22. Mickiewicz E, Porcella H, Roth B, et al.  Do patients with locally advanced cervical carcinoma responding to adjuvant chemotherapy benefit from a surgical approach? Preliminary report of a prospective randomised trial. Proc. ASCO. 1996;15:A823
  23. Park SY, Kim JH, Kim BG, et al.  Phase III randomized study of MVC intraarterial (arm 1), or systemic (arm 2) neoadjuvant chemotherapy versus radiation therapy only (arm3) for stage IIb bulky carcinoma of uterine cervix (preliminary report). Proc. ASCO. 1996;15:A840
  24. Kigawa J, Minagawa Y, Ishihara H, Itamochi H, Kanamori Y, Terawaka N. The role of neoadjuvant intra-arterial infusion chemotherapy with cisplatin and bleomycin for locally advanced cervical cancer. Am. J. Clin. Oncol. 1996;19:255–259
  25. Chang-Ting C, Lai C-H, Hong J-H, et al.  Randomized trial of neaodjuvant cisplatin, vincristine, bleomycin, and radical hysterectomy versus radiation therapy for bulky stage Ib and IIA cervical cancer. J. Clin. Oncol. 2000;18:1740–1747
  26. Benedetti-Panici P, Greggi S, Colombo A, et al.  Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced cervical cancer (results from the Italian multicenter randomised study). J. Clin. Oncol. 2002;20:179–188
  27. Stewart LA, Parmar MKB. Meta-analysis of the literature or of individual patient data (is there a difference?). Lancet. 1993;341:418–422
  28. Rose PG. Chemoradiotherapy for cervical cancer. Eur. J. Cancer. 2002;38:270–278
  29. Rew DA, Wilson GD. Cell production rates in human tissues and tumours and their significance. Part II (clinical data). Eur. J. Surg. Oncol. 2000;26:405–417
  30. Bolger BS, Symonds RP, Stanton PD, et al.  Prediction of radiotherapy response of cervical carcinoma through measurement of proliferation rate. Br. J. Cancer. 1996;74:1223–1226
  31. Perez CA, Grigsby PWC-VH, Lockett MA. Carcinoma of the cervix. I. Impact of prolongation of overall treatment time and timing of brachytherapy on the outcome of radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 1995;32:1275–1288
  32. Petereit DG, Sarkaria JN, Chappell R, et al.  The adverse effect of treatment prolongation in cervical carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 1995;32:1301–1307
  33. Eifel PJ, Thames HD. Has the influence of treatment duration on local control of carcinoma of the cervix been defined?. Int. J. Radiat. Oncol. Biol. Phys. 1995;32:1527–1529
  34. Pignon JP, Bourhis J, Domenge C, Designé L  on behalf of the MACH-NC Collaborative Group . Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma (three meta-analyses of updated individual data). Lancet. 2000;355:949–955
  35. Tattersall MHN, Ramirez C, Coppleson M. A randomized trial comparing platinum-based chemotherapy followed by radiotherapy alone in patients with locally advanced cervical cancer. Int. J. Gynecol. Cancer. 1992;2:244–251
  36. Cárdenas J, Olguı́n A, Figueroa F, Peña J, Beccerra F, Huizar R. A randomized trial of chemotherapy (CT) followed by radiotherapy (RT) vs radiotherapy alone in stage IIIb cervical carcinoma (preliminary results). Fourth International Congress on Anti-Cancer Chemotherapy, Paris, France. 1993;87
  37. Cárdenas J, Olguı́n A, Figueroa F, Beccerra F, Huizar R. Randomized neoadjuvant chemotherapy in cervical carcinoma stage IIb. PEC+ RT vs RT. Proc. ASCO. 1991;10:A620
  38. Chiara S, Bruzzone M, Merlini L, et al.  Randomized study comparing chemotherapy plus radiotherapy versus radiotherapy alone in FIGO stage IIB–III cervical carcinoma. Am. J. Clin. Oncol. 1994;17:294–297
  39. Sundfor K, Tropé CG, Högberg T, et al.  Radiotherapy and neoadjuvant chemotherapy for cervical carcinoma. A randomized multicenter study of sequential cisplatin and 5-fluorouracil and radiotherapy in advanced cervical carcinoma stage 3B and 4A. Cancer. 1996;77:2371–2378
  40. Symonds RP, Habeshaw T, Reed NS, et al.  The Scottish and Manchester randomised trial of neo-adjuvant chemotherapy for advanced cervical cancer. Eur. J. Cancer. 2000;36:994–1001
  41. Leborgne F, Leborgne JH, Doldán R, et al.  Induction chemotherapy and radiotherapy of advanced cancer of the cervix (a pilot study and phase III randomized trial). Int. J. Radiat. Oncol. Biol. Phys. 1997;37:343–350

PII: S0959-8049(03)00425-8

doi: 10.1016/S0959-8049(03)00425-8

European Journal of Cancer
Volume 39, Issue 17 , Pages 2470-2486 , November 2003