European Journal of Cancer
Volume 41, Issue 13 , Pages 1875-1888 , September 2005

Karyometry in the early detection and chemoprevention of intraepithelial lesions

  • J. Ranger-Moore

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • Corresponding Author InformationCorrespondence author. Tel.: +1 520 626 3118; fax: +1 520 626 2467.
    • ,
  • D.S. Alberts

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • ,
  • R. Montironi

      Affiliations

    • Polytechnic University of the Marche Region ef, Ancona, Italy
    • ,
  • F. Garcia

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • ,
  • J. Davis

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • ,
  • D. Frank

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • ,
  • M. Brewer

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • ,
  • G.M. Mariuzzi

      Affiliations

    • University of Verona, Verona, Italy
    • ,
  • H.G. Bartels

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA
    • ,
  • P.H. Bartels

      Affiliations

    • University of Arizona, P.O. Box 245024, Tucson, Arizona, AZ 85724-5024, USA

Received 4 May 2005 ,Revised 1 July 2005 ,Accepted 6 July 2005.

References 

  1. Grundmann E, Stein P. Untersuchungen ueber die Kernstrukturen in normalen Geweben und im Carcinom. Beitr Pathol Anat. 1968;125:54–76
  2. Harbers E, Sandritter W. Gesteigerte Heterchromatisierung als pathogenetisches Prinzip. Deutsche Med. Wochenschrift. 1996;93:269–271
  3. Bartels PH, Montironi R, Hamilton PW, et al. Nuclear chromatin texture in prostatic lesions. II. PIN and malignancy associated changes. Anal Quant Cytol Histol. 1998;20(5):397–406
  4. Susnik B, Worth A, LeRiche J, et al. Malignancy associated changes in the breast. Changes in chromatin distribution in epithelial cells in normal appearing tissue adjacent to cancer. Anal Quant Cytol Histol. 1995;17:62–68
  5. King EB, Kromout LK, Chew KL, et al. Analytic studies of foam cells from breast cancer precursors. Cytometry. 1984;5:124–130
  6. Anderson NHJ, Kirk SJ, Frank D, et al. Malignancy-associated changes in lactiferous duct epithelium. Anal Quant Cytol Histol. 2003;25(2):63–72
  7. Brewer MA, Ranger-Moore J, Greene MH, et al. Preneoplastic changes in ovarian tissues. Anal Quant Cytol Histol. 2004;26(4):207–216
  8. Brewer MA, Ranger-Moore J, Baruche A, et al. Exploratory study of ovarian intraepithelial neoplasia. Cancer Epidem Biomar Prevent. 2005;14(2):299–305
  9. Wied GL, Bartels PH, Bibbo M, et al. Cytomorphometric markers for uterine cancer in intermediate cells. Anal Quant Cytol Histol. 1980;2(4):257–263
  10. Bibbo M, Bartels PH, Sychra JJ, et al. Chromatin appearance in intermediate cells from patients with uterine cancer. Acta Cytol. 1981;25(1):23–28
  11. Burger GJU, Rodenacker C. Changes in benign cell populations in cases of cervical cancer and its precursors. Anal Quant Cytol Histol. 1981;3:261–271
  12. Vooijs PG, Oud PS, Zahniser DJ, et al. Chromatin measurements in Feulgen stained intermediate cells from normal and abnormal cervical smears. Analyt Quant Cytol. 1982;4:154
  13. Reinhardt ER, Lenz R, Greiner W, et al. Diagnostic relevance of visually nonsuspect cells for cancer diagnosis. Anal Quant Cytol Histol. 1982;4:157
  14. Kwikkel HJ, Timmers T, Boone ME, et al. Relation of quantitative features of visually normal intermediate cells in cervical intraepithelial neoplasis I and II smears to progression or non-progression of the lesion. Anal Quant Cytol Histol. 1987;9:405–410
  15. Haroske G, Bernander ST, Koenig R, et al. Application of malignancy associated changes of the cervical epithelium in a hierarchic classification concept. Anal Cell Path. 1990;2:189–198
  16. Montag AG, Bartels PH, Lerma-Puertas E, et al. Karyometric marker features in tissue adjacent to in situ cervical carcinomas. Anal Quant Cytol Histol. 1989;11(4):275–280
  17. Bibbo M, Montag AG, Lerma-Puertas E, et al. Karyometric marker features in tissue adjacent to invasive cervical carcinomas. Anal Quant Cytol Histol. 1989;11(4):281–285
  18. MacAulay C, Lam S, Payner PW, et al. Malignancy associated changes in bronchial epithelial cells in biopsy specimens. Anal Quant Cytol Histol. 1995;17:55–71
  19. Montag AG, Bartels PH, Dytch HE, et al. Karyometric features in nuclei near colonic adenocarcinoma. Statistical analysis. Anal Quant Cytol Histol. 1991;13(3):159–167
  20. Ranger-Moore J, Frank D, Lance P, et al. Karyometry in rectal mucose of patients with previous colorectal adenomas. Anal Quant Cytol Histol. 2005;27:134–142
  21. daSilva VD, Prolla JC, Sharma P, et al. Karyometry in Barrett’s Esophagus. Anal Quant Cytol Histol. 2001;23(1):40–46
  22. Bibbo M, Bartels PH, Galera-Davidson H, et al. Markers for malignancy in the nuclear texture of histologically normal tissue from patients with thyroid tumors. Anal Quant Cytol Histol. 1986;8(2):168–176
  23. Lerma-Puertas E, Galera-Davidson H, Bartels PH, et al. Karyometric marker features in fine needle aspirates of follicular adenoma of the thyroid. Anal Quant Cytol Histol. 1990;12(4):223–228
  24. Montironi R, Scarpelli M, Mazzucchelli R, et al. Subvisual chromatin changes are detected in the histologically normal urothelium in patients with synchronous papillary carcinoma. Hum Pathol. 2003;34(9):893–901
  25. Bartels PH, Montironi R, Hamilton PW, et al. Nuclear chromatin texture in prostatic lesions. I. PIN and adenocarcinoma. Anal Quant Cytol Histol. 1998;20(5):389–396
  26. Calaluce R, Kunkel M, Watts G, et al. Liminin-5-mediated gene expression in human prostate carcinoma cells. Mol Carcinogen. 2001;30(2):119–129
  27. Bartels PH, daSilva VD, Montironi R, et al. Chromatin texture signatures in nuclei from prostate lesions. Anal Quant Cytol Histol. 1998;20(5):407–416
  28. Bartels PH, Ranger-Moore J, Bartels HG, et al. Second order discriminant analysis in chemopreventive efficacy measurement. Anal Quant Ctyol Histol. 2005;27:15–26
  29. Tsybrovskyy O, Berghold A. Application of multilevel models to morphometric data. Part 1. Linear models and hypothesis testing. Anal Cell Pathol. 2003;25:173–185
  30. Tsybrovskyy O, Berghold A. Application of multilevel models to morphometric data. Part 2. Correlations. Anal Cell Pathol. 2003;25:187–191
  31. Ranger-Moore J, Bozzo P, Alberts DS, et al. Karyometry of nuclei from actinic keratosis and squamous cell cancer of the skin. Anal Quant Ctyol Histol. 2003;25(6):353–361
  32. Wolfe P, Murphy J, McGinley J, et al. Using nuclear morphometry to discriminate the tumorigenic potential of cells: a comparison of statistical methods. Cancer Epidem Biomar Prevent. 2004;13(6):976–988
  33. Raudenbush SW. Statistical analysis and optimal design in cluster randomized trials. Psychol Meth. 1997;2(2):173–185
  34. Garret JM. Sample size estimation for cluster designed samples. Stat Tech Bull. 2001;60:41–45
  35. Bartels PH, Garcia FAR, Davis J, et al. Progression curves for endometrial lesions. Anal Quant Cytol Histol. 2001;23:1–8
  36. Mariuzzi L, Mombello A, Rucco V, et al. Quantitative study of ductal breast cancer progression: signatures of nuclei in proliferating breast lesions and in situ cancers. Adv Clin Path. 2000;4:87–97
  37. Bartels PH, Thompson D, Montironi R, et al. Digital knowledge and diagnostic information. J Histotechnol. 2000;23(3):183–190
  38. Bozzo PD, Alberts DS, Vaught L, et al. Measurement of chemopreventive efficacy in skin biopsies. Anal Quant Cytol Histol. 2001;23:300–312
  39. Alberts DS, Ranger-Moore J, Einspahr J, et al. Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin. Clin Cancer Res. 2004;10(6):1875–1880
  40. Bartels PH, Ranger-Moore J, Stratton MS, et al. Statistical Analysis of chemopreventive efficacy of vitamin A in sun-exposed, normal skin. Anal Quant Cytol Histol. 2002;24(4):185–197
  41. Swed FS, Eisenhart C. Tables for testing randomness of grouping in a sequence of alternatives. Annal Math Stat. 1943;14:66–87Table II
  42. Garcia F, Davis J, Alberts DS, et al. A karyometric approach to the characterization of atypical endometrial hyperplasia with and without co-ocurring adenocarcinoma. Anal Quant Cytol Histol. 2003;25:246–339
  43. McClellan RP. Optimization and stochastic approximation techniques applied to unsupervised learning. Master’s thesis, Tucson: University of Arizona, 1971.
  44. Bartels PH, Olson GB. Computer analysis of lymphocyte images. In:  Catsimpoolas N editors. Methods of cell separation. New York: Plenum Press; 1980;p. 1–99
  45. Montironi R, Scarpelli M, Mazzucchelli R, et al. Subvisual changes in chromatin organization state are detected by karyometry in the histologically normal urothelium in patients with synchronous papillary carcinoma. Hum Pathol. 2003;34(9):893–901
  46. Gail MH, Brinton LA, Byar DP, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst. 1989;81(24):1879–1886
  47. Moon TE, Levine N, Cartmel B, et al. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Cancer Epidem Biomar Prevent. 1997;6(11):949–956

PII: S0959-8049(05)00519-8

doi: 10.1016/j.ejca.2005.07.002

European Journal of Cancer
Volume 41, Issue 13 , Pages 1875-1888 , September 2005

Article Tools

* Image Usage & Resolution