European Journal of Cancer
Volume 42, Issue 5 , Pages 617-620 , March 2006

Intraoperative sentinel lymph node examination by frozen section, immunohistochemistry and imprint cytology during breast surgery – A prospective study

  • F. Celebioglu

      Affiliations

    • Department for Clinical Science, Intervention and Technology, Karolinska University Hospital Solna, Division of Surgery/Bröstcentrum, 17176 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author: Tel.: +46 8 5 177 9215.
    • ,
  • M. Sylvan

      Affiliations

    • Department of Pathology, Karolinska University Hospital, Huddinge, Sweden
    • ,
  • L. Perbeck

      Affiliations

    • Department for Clinical Science, Intervention and Technology, Karolinska University Hospital Solna, Division of Surgery/Bröstcentrum, 17176 Stockholm, Sweden
    • ,
  • L. Bergkvist

      Affiliations

    • Department of Surgery, Centre for Clinical Research, Uppsala University, Central Hospital, Västerås, Sweden
    • ,
  • J. Frisell

      Affiliations

    • Department for Clinical Science, Intervention and Technology, Karolinska University Hospital Solna, Division of Surgery/Bröstcentrum, 17176 Stockholm, Sweden

Received 30 June 2005 ,Revised 12 October 2005 ,Accepted 9 December 2005.

References 

  1. Chadha M, Chabon AB, Friedmann P, et al. Predictors of axillary lymph node metastases in patients with T1 breast cancer. A multivariate analysis. Cancer. 1994;73(2):350–353
  2. Recht A, Houlihan MJ. Axillary lymph nodes and breast cancer: a review. Cancer. 1995;76(9):1491–1512
  3. Ivens D, Hoe AL, Podd TJ, et al. Assessment of morbidity from complete axillary dissection. Br J Cancer. 1992;66(1):136–138
  4. Liljegren G, Holmberg L. Arm morbidity after sector resection and axillary dissection with or without postoperative radiotherapy in breast cancer stage I. Results from a randomised trial. Uppsala-Orebro Breast Cancer Study Group. Eur J Cancer. 1997;33(2):193–199
  5. Krag D, Weaver D, Ashikaga T, et al. The sentinel node in breast cancer – a multicenter validation study. New Engl J Med. 1998;339(14):941–946
  6. Giuliano AE, Kirgan DM, Guenther JM, et al. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Annu Surg. 1994;220(3):391–398discussion 398–401
  7. Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet. 1997;349(9069):1864–1867
  8. Schrenk P, Rieger R, Shamiyeh A, et al. Morbidity following sentinel lymph node biopsy versus axillary lymph node dissection for patients with breast carcinoma. Cancer. 2000;88(3):608–614
  9. Brogi E, Torres-Matundan E, Tan LK, et al. The results of frozen section, touch preparation, and cytological smear are comparable for intraoperative examination of sentinel lymph nodes: a study in 133 breast cancer patients. Ann Surg Oncol. 2005;12(2):173–180
  10. Bergkvist L, Frisell J, Liljegren G, et al. Multicentre study of detection and false-negative rates in sentinel node biopsy for breast cancer. Br J Surg. 2001;88(12):1644–1648
  11. Singletary SE, Allred C, Ashley P, et al. Staging system for breast cancer revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am. 2003;83(4):803–819
  12. Singletary SE, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol. 2002;20(17):3628–3636
  13. Llatjos M, Castella E, Fraile M, et al. Intraoperative assessment of sentinel lymph nodes in patients with breast carcinoma: accuracy of rapid imprint cytology compared with definitive histologic workup. Cancer. 2002;96(3):150–156
  14. van Diest PJ, Torrenga H, Meijer S, et al. Pathologic analysis of sentinel lymph nodes. Semin Surg Oncol. 2001;20(3):238–245
  15. Van Diest PJ, Torrenga H, Borgstein PJ, et al. Reliability of intraoperative frozen section and imprint cytological investigation of sentinel lymph nodes in breast cancer. Histopathology. 1999;35(1):14–18
  16. Rahusen FD, Pijpers R, Van Diest PJ, et al. The implementation of the sentinel node biopsy as a routine procedure for patients with breast cancer. Surgery. 2000;128(1):6–12
  17. Dixon JM, Mamman U, Thomas J. Accuracy of intraoperative frozen-section analysis of axillary nodes. Edinburgh Breast Unit team. Br J Surg. 1999;86(3):392–395
  18. Grabau DA, Rank F, Friis E. Intraoperative frozen section examination of axillary sentinel lymph nodes in breast cancer. Apmis. 2005;113(1):7–12
  19. Khalifa K, Pereira B, Thomas VA, et al. The accuracy of intraoperative frozen section analysis of the sentinel lymph nodes during breast cancer surgery. Int J Fertil Womens Med. 2004;49(5):208–211
  20. Motomura K, Komoike Y, Inaji H, et al. Multiple sectioning and immunohistochemical staining of sentinel nodes in patients with breast cancer. Br J Surg. 2002;89(8):1032–1034
  21. Viale G, Bosari S, Mazzarol G, et al. Intraoperative examination of axillary sentinel lymph nodes in breast carcinoma patients. Cancer. 1999;85(11):2433–2438
  22. Nahrig JM, Richter T, Kuhn W, et al. Intraoperative examination of sentinel lymph nodes by ultrarapid immunohistochemistry. Breast J. 2003;9(4):277–281
  23. Turner RR, Hansen NM, Stern SL, et al. Intraoperative examination of the sentinel lymph node for breast carcinoma staging. Am J Clin Pathol. 1999;112(5):627–634
  24. Wada N, Imoto S, Hasebe T, et al. Evaluation of intraoperative frozen section diagnosis of sentinel lymph nodes in breast cancer. Jpn J Clin Oncol. 2004;34(3):113–117
  25. Prognostic importance of occult axillary lymph node micrometastases from breast cancers. International (Ludwig) Breast Cancer Study Group. Lancet 1990;335(8705):1565–8.
  26. Wilkinson E, Hause L, Hoffman R, et al. Occult axillary lymph node metastases in invasive breast carcinoma: characteristics of the primary tumour and significance of the metastases. Pathol Annu. 1998;17:67–91
  27. Deo S, Samaiya A, Jain P, et al. Sentinel lymph node biopsy assessment using intraoperative imprint cytology in breast cancer patients: results of a validation study. Asian J Surg. 2004;27(4):294–298
  28. Kane JM, Edge SB, Winston JS, et al. Intraoperative pathologic evaluation of a breast cancer sentinel lymph node biopsy as a determinant for synchronous axillary lymph node dissection. Ann Surg Oncol. 2001;8(4):361–367
  29. Zgajnar J, Frkovic-Grazio S, Besic N, et al. Low sensitivity of the touch imprint cytology of the sentinel lymph node in breast cancer patients results of a large series. J Surg Oncol. 2004;85(2):82–86discussion 87
  30. Pogacnik A, Klopcic U, Grazio-Frkovic S, et al. The reliability and accuracy of intraoperative imprint cytology of sentinel lymph nodes in breast cancer. Cytopathology. 2005;16(2):71–76
  31. Cox C, Centeno B, Dickson D, et al. Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma. Cancer. 2005;105(1):13–20
  32. Aihara T, Munakata S, Morino H, et al. Comparison of frozen section and touch imprint cytology for evaluation of sentinel lymph node metastasis in breast cancer. Ann Surg Oncol. 2004;11(8):747–750

PII: S0959-8049(05)01079-8

doi: 10.1016/j.ejca.2005.12.003

European Journal of Cancer
Volume 42, Issue 5 , Pages 617-620 , March 2006

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