European Journal of Cancer
Volume 42, Issue 15 , Pages 2492-2498, October 2006

Numerous high-risk epithelial lesions in familial breast cancer

  • N. Hoogerbrugge

      Affiliations

    • Department of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • Department of Medical Oncology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • Corresponding Author InformationCorresponding author: Tel.: +31 24 3616577; fax: +31 24 3565026.
    • ,
  • P. Bult

      Affiliations

    • Department of Pathology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • ,
  • J.J. Bonenkamp

      Affiliations

    • Department of Surgery, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • ,
  • M.J.L. Ligtenberg

      Affiliations

    • Department of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • Department of Pathology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • ,
  • L.A. Kiemeney

      Affiliations

    • Department of Epidemiology and Biostatistics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • ,
  • J.A. de Hullu

      Affiliations

    • Department of Obstetrics and Gynecology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • ,
  • C. Boetes

      Affiliations

    • Department of Radiodiagnostics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
    • ,
  • M.F. Niermeijer

      Affiliations

    • Department of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • ,
  • H.G. Brunner

      Affiliations

    • Department of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Received 27 January 2006; received in revised form 24 May 2006; accepted 24 May 2006.

Abstract 

Purpose

To assess the occurrence of high-risk epithelial lesions in women of breast cancer families with and without a BRCA mutation.

Patients and methods

Prospective study of women at very high risk of breast cancer undergoing prophylactic mastectomy (68 BRCA1 mutation carriers, 14 BRCA2 mutation carriers and 24 non-BRCA mutation carriers).

Results

The prevalence of high-risk lesions is equal in women with a BRCA1 or a BRCA2 mutation, but is higher in non-BRCA mutation carriers: all lesions 43% versus 71% (p=0.02), atypical lobular hyperplasia 26% versus 67% (p=0.001), atypical ductal hyperplasia 17% versus 42% (p=0.01), lobular carcinoma-in situ 15% versus 29% (p=0.10) and ductal carcinoma-in situ 9% versus 17% (p=0.25). The presence of high-risk lesions is related to absence of a BRCA mutation and to age over 40 years.

Conclusion

Women with an autosomal dominant family history for breast cancer, with and without a BRCA mutation are prone to develop high-risk epithelial lesions, especially over 40 years.

Keywords: Breast cancer, Hereditary, BRCA, Preventive mastectomy, Familial, DCIS, LCIS

 

PII: S0959-8049(06)00529-6

doi:10.1016/j.ejca.2006.05.027

European Journal of Cancer
Volume 42, Issue 15 , Pages 2492-2498, October 2006