Numerous high-risk epithelial lesions in familial breast cancer
Received 27 January 2006; received in revised form 24 May 2006; accepted 24 May 2006.
Abstract
Purpose
To assess the occurrence of high-risk epithelial lesions in women of breast cancer families with and without a BRCA mutation.
Patients and methods
Prospective study of women at very high risk of breast cancer undergoing prophylactic mastectomy (68 BRCA1 mutation carriers, 14 BRCA2 mutation carriers and 24 non-BRCA mutation carriers).
Results
The prevalence of high-risk lesions is equal in women with a BRCA1 or a BRCA2 mutation, but is higher in non-BRCA mutation carriers: all lesions 43% versus 71% (p=0.02), atypical lobular hyperplasia 26% versus 67% (p=0.001), atypical ductal hyperplasia 17% versus 42% (p=0.01), lobular carcinoma-in situ 15% versus 29% (p=0.10) and ductal carcinoma-in situ 9% versus 17% (p=0.25). The presence of high-risk lesions is related to absence of a BRCA mutation and to age over 40 years.
Conclusion
Women with an autosomal dominant family history for breast cancer, with and without a BRCA mutation are prone to develop high-risk epithelial lesions, especially over 40 years.
aDepartment of Human Genetics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
bDepartment of Medical Oncology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
cDepartment of Pathology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
dDepartment of Surgery, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
eDepartment of Epidemiology and Biostatistics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
fDepartment of Obstetrics and Gynecology, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
gDepartment of Radiodiagnostics, From the Hereditary Cancer Clinic, Radboud University Nijmegen Medical Centre, The Netherlands
ABSTRACT