European Journal of Cancer
Volume 42, Issue 15 , Pages 2463-2471 , October 2006

Are men with low selenium levels at increased risk of prostate cancer?

  • Maree Brinkman

      Affiliations

    • Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Blok J, 3000 Leuven, Belgium
    • Corresponding Author InformationCorresponding author: Tel.: +32 16 332 696; fax: +32 16 337 480.
    • ,
  • Raoul C. Reulen

      Affiliations

    • Department of Public Health and Epidemiology, University of Birmingham, Birmingham B15 2TT, United Kingdom
    • ,
  • Eliane Kellen

      Affiliations

    • Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Blok J, 3000 Leuven, Belgium
    • ,
  • Frank Buntinx

      Affiliations

    • Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Blok J, 3000 Leuven, Belgium
    • Department of General Practice and Research Institute Caphri, Maastricht University, The Netherlands
    • ,
  • Maurice P. Zeegers

      Affiliations

    • Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Blok J, 3000 Leuven, Belgium
    • Department of Public Health and Epidemiology, University of Birmingham, Birmingham B15 2TT, United Kingdom

Received 17 February 2006 ,Revised 26 February 2006 ,Accepted 28 February 2006.

References 

  1. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2002. In: Cancer incidence, mortality and prevalence worldwide. IARC Cancer Base No. 5 Version 2.0. Lyon, France: IARC Press; 2004;
  2. Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer. 1991;63(6):963–966
  3. Platz EA, Helzlsouer KJ. Selenium, zinc, and prostate cancer. Epidemiol Rev. 2001;23(1):93–101
  4. Shamberger RJ, Tytko SA, Willis CE. Antioxidants and cancer Part VI. Selenium and age-adjusted human cancer mortality. Arch Environ Health. 1976;31(5):231–235
  5. Schrauzer GN, White DA, Schneider CJ. Cancer mortality correlation studies–III: statistical associations with dietary selenium intakes. Bioinorg Chem. 1977;7(1):23–31
  6. Clark LC, Combs GF, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996;276(24):1957–1963
  7. Duffield-Lillico AJ, Dalkin BL, Reid ME, et al. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. 2003;91(7):608–612
  8. Stratton MS, Reid ME, Schwartzberg G, et al. Selenium and inhibition of disease progression in men diagnosed with prostate carcinoma: study design and baseline characteristics of the ’Watchful Waiting’ Study. Anticancer Drugs. 2003;14(8):595–600
  9. Stratton MS, Reid ME, Schwartzberg G, et al. Selenium and prevention of prostate cancer in high-risk men: the Negative Biopsy Study. Anticancer Drugs. 2003;14(8):589–594
  10. Klein EA. Selenium and vitamin E cancer prevention trial. Ann NY Acad Sci. 2004;1031:234–241
  11. Li H, Stampfer MJ, Giovannucci EL, et al. A prospective study of plasma selenium levels and prostate cancer risk. J Natl Cancer Inst. 2004;96(9):696–703
  12. Nomura AM, Lee J, Stemmermann GN, Combs GF. Serum selenium and subsequent risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2000;9(9):883–887
  13. Yoshizawa K, Willett WC, Morris SJ, et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst. 1998;90(16):1219–1224
  14. Van den Brandt PA, Zeegers MP, Bode P, Goldbohm RA. Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2003;12(9):866–871
  15. Helzlsouer KJ, Huang HY, Alberg AJ, et al. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst. 2000;92(24):2018–2023
  16. West DW, Slattery ML, Robison LM, French TK, Mahoney AW. Adult dietary intake and prostate cancer risk in Utah: a case-control study with special emphasis on aggressive tumors. Cancer Causes Control. 1991;2(2):85–94
  17. Hartman TJ, Albanes D, Pietinen P, et al. The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev. 1998;7(4):335–340
  18. Knekt P, Aromaa A, Maatela J, et al. Serum selenium and subsequent risk of cancer among Finnish men and women. J Natl Cancer Inst. 1990;82(10):864–868
  19. Etminan M, FitzGerald JM, Gleave M, Chambers K. Intake of selenium in the prevention of prostate cancer: a systematic review and meta-analysis. Cancer Causes Control. 2005;16(9):1125–1131
  20. Kornitzer M, Valente F, De Bacquer D, Neve J, De Backer G. Serum selenium and cancer mortality: a nested case-control study within an age- and sex-stratified sample of the Belgian adult population. Eur J Clin Nutr. 2004;58(1):98–104
  21. Navarro-Alarcon M, de la Serrana HL, Perez-Valero V, Lopez-Martinez C. Serum selenium levels as indicators of body status in cancer patients and their relationship with other nutritional and biochemical markers. Sci Total Environ. 1998;212(2-3):195–202
  22. Hardell L, Degerman A, Tomic R, Marklund SL, Bergfors M. Levels of selenium in plasma and glutathione peroxidase in erythrocytes in patients with prostate cancer or benign hyperplasia. Eur J Cancer Prev. 1995;4(1):91–95
  23. Moul JW. Population screening for prostate cancer and emerging concepts for young men. Clin Prostate Cancer. 2003;2(2):87–97
  24. Allen NE, Morris JS, Ngwenyama RA, Key TJ. A case–control study of selenium in nails and prostate cancer risk in British men. Br J Cancer. 2004;90(7):1392–1396
  25. Lipsky K, Zigeuner R, Zischka M, et al. Selenium levels of patients with newly diagnosed prostate cancer compared with control group. Urology. 2004;63(5):912–916
  26. Vogt TM, Ziegler RG, Graubard BI, et al. Serum selenium and risk of prostate cancer in U.S. blacks and whites. Int J Cancer. 2003;103(5):664–670
  27. Willett WC, Polk BF, Morris JS, et al. Prediagnostic serum selenium and risk of cancer. Lancet. 1983;2(8342):130–134
  28. Peleg I, Morris S, Hames CG. Is serum selenium a risk factor for cancer?. Med Oncol Tumor Pharmacother. 1985;2(3):157–163
  29. Perez-Beriain R, Comet A, Castrillo J, et al. Selenium and prostate. Met Ion Biol. 2002;7:586–588
  30. Hedges L, Olkin I. Statistical methods for meta-analysis. Orlando (FL): Academic Press; 1985;
  31. Cohen J. Statistical power analysis for the behavioural sciences. 2nd ed.. Hillside (NJ): Erlbaum; 1988;
  32. Egger M, Davey Smith G, Altman DG. Systematic reviews in health care. London: BMJ Publishing Group; 2001;
  33. Berkey CS, Hoaglin DC, Antczak-Bouckoms A, Mosteller F, Colditz GA. Meta-analysis of multiple outcomes by regression with random effects. Stat Med. 1998;17(22):2537–2550
  34. Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634
  35. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455–463
  36. Stata Statistical Software, Release 8.0 Intercooled, TX [computer program]; 2003.
  37. Lee MM, Wang RT, Weal Hsing A. Case–control study of diet and prostate cancer in China. Cancer Causes Control. 1998;9(6):545–552
  38. Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM. Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand). Cancer Causes Control. 2000;11(7):609–615
  39. Key TJ, Silcocks PB, Davey GK, Appleby PN, Bishop DT. A case–control study of diet and prostate cancer. Br J Cancer. 1997;76(5):678–687
  40. Jain MG, Hislop GT, Howe GR, Ghadirian P. Plant foods, antioxidants, and prostate cancer risk: findings from case–control studies in Canada. Nutr Cancer. 1999;34(2):173–184
  41. Salonen JT, Salonen R, Lappetelainen R, Maenpaa PH, Alfthan G, Puska P. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case–control analysis of prospective data. Br Med J (Clin Res Ed). 1985;290(6466):417–420
  42. Criqui MH, Bangdiwala S, Goodman DS, et al. Selenium, retinol, retinol-binding protein, and uric acid. Associations with cancer mortality in a population-based prospective case-control study. Ann Epidemiol. 1991;1(5):385–393
  43. Fex G, Pettersson B, Akesson B. Low plasma selenium as a risk factor for cancer death in middle-aged men. Nutr Cancer. 1987;10(4):221–229
  44. Kok FJ, De Bruijn AM, Hofman A, Valkenburg HA. Selenium status and chronic disease mortality: Dutch epidemiological findings. Int J Epidemiol. 1987;16(2):329–332
  45. Drasch G, Schopfer J, Schrauzer GN. Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and nonsmokers, and relevance to the cancer protective effects of selenium. Biol Trace Elem Res. 2005;103(2):103–107
  46. Nyman DW, Suzanne SM, Kopplin MJ, Dalkin BL, Nagle RB, Jay GA. Selenium and selenomethionine levels in prostate cancer patients. Cancer Detect Prev. 2004;28(1):8–16
  47. Zachara BA, Szewczyk-Golec K, Wolski Z, et al. Selenium level in benign and cancerous prostate. Biol Trace Elem Res. 2005;103(3):199–206
  48. Darago A, Sapota A, Duda-Szymanska J. Levels of cadmium, zinc, copper and selenium in subjects with diagnosed prostate cancer. Rocz Panstw Zakl Hig. 2003;54 Suppl.:39–40
  49. Ujiie S, Kikuchi H. The relation between serum selenium value and cancer in Miyagi, Japan: 5-year follow up study. Tohoku J Exp Med. 2002;196(3):99–109
  50. Jia ZG. Analysis of serum levels of selenium, zinc, and copper in 132 patients with malignant tumors. Zhonghua Yu Fang Yi Xue Za Zhi. 1991;25(4):205–207
  51. Turan B. The serum selenium and immunoglobulins levels and healthy and cancer cases. Biyokimya Dergisi. 1992;17:29–36
  52. Rohrmann S, Smit E, Giovannucci E, Platz EA. Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey. Urology. 2004;64(3):504–509
  53. Ringstad J, Jacobsen BK, Tretli S, Thomassen Y. Serum selenium concentration associated with risk of cancer. J Clin Pathol. 1988;41(4):454–457
  54. Coates RJ, Weiss NS, Daling JR, Morris JS, Labbe RF. Serum levels of selenium and retinol and the subsequent risk of cancer. Am J Epidemiol. 1988;128(3):515–523
  55. Gupta S, Narang R, Krishnaswami K, Yadav S. Plasma selenium level in cancer patients. Indian J Cancer. 1994;31(3):192–197
  56. Backovic D, Stamenic V, Marmut Z, Jorga J. Blood selenium in healthy persons and individuals with malignant diseases. Srp Arh Celok Lek. 1998;126(1–2):18–22
  57. Salonen JT, Alfthan G, Huttunen JK, Puska P. Association between serum selenium and the risk of cancer. Am J Epidemiol. 1984;120(3):342–349
  58. Bratakos MS, Vouterakos TP, Ioannou PV. Selenium status of cancer patients in Greece. Sci Total Environ. 1990;92:207–222
  59. McConnell KP, Broghamer WL, Blotcky AJ, Hurt OJ. Selenium levels in human blood and tissues in health and in disease. J Nutr. 1975;105(8):1026–1031
  60. Broghamer WL, McConnell KP, Blotcky AL. Relationship between serum selenium levels and patients with carcinoma. Cancer. 1976;37(3):1384–1388
  61. Robinson MF, Godfrey PJ, Thomson CD, Rea HM, van Rij AM. Blood selenium and glutathione peroxidase activity in normal subjects and in surgical patients with and without cancer in New Zealand. Am J Clin Nutr. 1979;32(7):1477–1485
  62. Ke-Jun N, Feng-Jie X, Shi-Yong Y. Serum selenium and blood glutathione peroxidase in cancer patients. Chin J Clin Oncol. 1998;25:51–53
  63. Shamberger RJ, Rukovena E, Longfield AK, Tytko SA, Deodhar S, Willis CE. Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients. J Natl Cancer Inst. 1973;50(4):863–870
  64. Brooks JD, Metter EJ, Chan DW, et al. Plasma selenium level before diagnosis and the risk of prostate cancer development. J Urol. 2001;166(6):2034–2038
  65. Goodman GE, Schaffer S, Bankson DD, Hughes MP, Omenn GS. Predictors of serum selenium in cigarette smokers and the lack of association with lung and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2001;10(10):1069–1076
  66. Ghadirian P, Maisonneuve P, Perret C, et al. A case–control study of toenail selenium and cancer of the breast, colon, and prostate. Cancer Detect Prev. 2000;24(4):305–313
  67. Virtamo J, Valkeila E, Alfthan G, Punsar S, Huttunen JK, Karvonen MJ. Serum selenium and risk of cancer. A prospective follow-up of nine years. Cancer. 1987;60(2):145–148
  68. Torun M, Aldemir H, Yardim S. Serum selenium levels in various cancer types. Trace Elements Electroly. 1995;12(4):186–190
  69. Tsachev K, Tsvetkov M, Kumanov K, Mladenov D, Filev A. Serum selenium levels of patients with adenoma and carcinoma of the prostate gland. Khirurgiia (Sofiia). 1987;40(2):33–35
  70. Zachara BA, Szewczyk-Golec K, Tyloch J, et al. Blood and tissue selenium concentrations and glutathione peroxidase activities in patients with prostate cancer and benign prostate hyperplasia. Neoplasma. 2005;52(3):248–254
  71. Hoque A, Albanes D, Lippman SM, et al. Molecular epidemiologic studies within the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Causes Control. 2001;12(7):627–633
  72. Kumaraswamy E, Malykh A, Korotkov KV, et al. Structure-expression relationships of the 15-kDa selenoprotein gene Possible role of the protein in cancer etiology. J Biol Chem. 2000;275(45):35540–35547
  73. Reid ME, Stratton MS, Lillico AJ, et al. A report of high-dose selenium supplementation: response and toxicities. J Trace Elem Med Biol. 2004;18(1):69–74
  74. El Bayoumy K, Richie JP, Boyiri T, et al. Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. Cancer Epidemiol Biomarkers Prev. 2002;11(11):1459–1465

PII: S0959-8049(06)00576-4

doi: 10.1016/j.ejca.2006.02.027

European Journal of Cancer
Volume 42, Issue 15 , Pages 2463-2471 , October 2006

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