European Journal of Cancer
Volume 43, Issue 15 , Pages 2264-2269 , October 2007

Breast cancer in elderly women: Can radiotherapy be omitted?

Received 19 February 2007 ,Revised 5 April 2007 ,Accepted 7 June 2007.

References 

  1. Bartelink H, Horiot JC, Poortmans P, et al. Impact of radiation dosed on local control, fibrosis and survival after breast conserving treatment: 10 year results of the EORTC 22881-10882. Abstract 10. In: Proceedings of 29th annual San Antonio breast cancer symposium, December 2006.
  2. Clarke M, Collins R, Darby S, et al. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366:2087–2106
  3. Charlson ME, Pompei P, Ales KL, McKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383
  4. Coebergh JW, Janssen-Heijnen ML, Post PN, et al. Serious co-morbidity along unselected cancer patients newly diagnosed in the southeastern part of The Netherlands in 1993–1996. J Clin Epidemiol. 1999;52:1131–1136
  5. Cuzick J, Stewart H, Peto R, et al. Overview of randomized trials of postoperative adjuvant radiotherapy. Cancer Treat Rep. 1987;71:15–29
  6. Cuzick J, Stewart H, Rutqvist L, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol. 1994;12:447–453
  7. Fisher B. Laboratory and clinical research in breast cancer – a personal adventure: the David A Karnofsky memorial lecture. Cancer Res. 1980;40:3863–3874
  8. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effects of radiotherapy and surgery in early breast cancer: an overview of the randomised trials. N Eng J Med. 1995;333:1444–1455
  9. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet. 2000;355:1757–1770
  10. Fyles AW, McCready DR, Lee A, et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Eng J Med. 2004;351:963–970
  11. Hellman S. Karnofsky Memorial Lecture Natural history of small breast cancers. J Clin Oncol. 1994;12:2229–2234
  12. Hughes KS, Schnaper LA, Berry D, et al. Lupectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Eng J Med. 2004;351:971–977
  13. Kunkler IH, Prescott RJ, Williams LJ, King CC. When may adjuvant radiotherapy be avoided in operable breast cancer?. Clin Oncol. 2006;18:191–199
  14. Lee JC, Truong PT, Kader HA, et al. Postmastectomy radiotherapy reduces locoregional recurrence in elderly women with high-risk breast cancer. Clin Oncol. 2005;17:623–629
  15. Louwman WJ, Janssen-Heijnen ML, Houterman S, et al. Less extensive treatment and inferior prognosis for breast cancer patients with comorbidity: a population-based study. Eur J Cancer. 2005;41:779–785
  16. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Eng J Med. 1997;337:949–955
  17. Overgaard M, Jensen M-B, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet. 1999;353:1641–1648
  18. Prescott HRJ, Kunkler IH, Williams LJ, et al. PRIME I: assessing the impact of adjuvant breast radiotherapy on quality of life in low-risk older patients following breast conservation. Abstract 4080. In: Proceedings of 29th annual San Antonio breast cancer symposium, December 2006.
  19. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Eng J Med. 1997;337:956–962
  20. Razavi D. Étude des besoins et de l’organisation du soutien psychosocial des patients atteints d’un cancer et de leurs proches, Etude Fédérale, Ministère de la santé (www.fgov.health.be) avril 2005.
  21. Sader C, Ingram D, Hastrich D. Management of breast cancer in the elderly by complete local excision and tamoxifen alone. Aust N Z J Surg. 1999;69:790–793
  22. Sandison AJ, Gold DM, Wright P, Jones PA. Breast conservation or mastectomy: treatment choice of women aged 70 years and older. Br J Surg. 1996;83:994–996
  23. Smith BD, Haffty BG, Hurria A, et al. Postmastectomy radiation and survival in older women with breast cancer. J Clin Oncol. 2006;24:4901–4907
  24. Smith BD, Haffty BG, Buchholtz TA, et al. Effectiveness of radiation therapy in older women with ductal carcinoma in situ. J Nat Cancer Inst. 2006;98:1302–1310
  25. Smith BD, Gross CP, Smith GL, et al. Effectiveness of radiation therapy for older women with early breast cancer. J Nat Cancer Inst. 2006;98:681–690
  26. Truong PT, Bernstein V, Lesperance M, et al. Radiotherapy omission after breast-conserving surgery is associated with reduced breast cancer-specific survival in elderly women with breast cancer. Am J Surg. 2006;191:749–755
  27. Van Eycken E, De Wever N. Cancer incidence and survival in Flanders, 2000–2001. Flemish Cancer Registry Network, VLK, Brussels; 2006.
  28. Van Weel C, Schellevis FG. Comorbidity and guidelines: conflicting interests. Lancet. 2006;367:550–551
  29. Wanebo HJ, Cole B, Chung M, et al. Is surgical management compromised in elderly patient with breast cancer?. Ann Surg. 1997;225:579–589
  30. Whelan T, McKenzie R, Julian J, et al. Randomized trial of breast cancer irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Canc Inst. 2002;94:1143–1150

PII: S0959-8049(07)00466-2

doi: 10.1016/j.ejca.2007.06.003

European Journal of Cancer
Volume 43, Issue 15 , Pages 2264-2269 , October 2007