European Journal of Cancer
Volume 45, Issue 1 , Pages 146-153 , January 2009

MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma

  • J. Sadones

      Affiliations

    • Medical Oncology, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    • ,
  • A. Michotte

      Affiliations

    • Experimental Pathology and Neuropathology, UZ Brussel, Laarbeeklaan 101, B1090 Brussels, Belgium
    • ,
  • P. Veld

      Affiliations

    • Experimental Pathology and Neuropathology, UZ Brussel, Laarbeeklaan 101, B1090 Brussels, Belgium
    • ,
  • C. Chaskis

      Affiliations

    • Neurosurgery, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    • ,
  • R. Sciot

      Affiliations

    • Pathology, Universitair Ziekenhuis Leuven, Campus Sint-Rafael, Minderbroedersstraat 12, B-3000 Leuven, Belgium
    • ,
  • J. Menten

      Affiliations

    • Radiotherapy-Oncology, Universitair Ziekenhuis Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    • ,
  • E.J.R. Joossens

      Affiliations

    • Medical Oncology, Ziekenhuis Netwerk Middelheim, Lindendreef 1, 2020 Antwerp, Belgium
    • ,
  • T. Strauven

      Affiliations

    • Neurology, AZ St.-Augustinus, Oosterveldlaan 24, 2610 Antwerp, Belgium
    • ,
  • L.A. D’Hondt

      Affiliations

    • Medical Oncology, Centre Hospitalier Notre-Dame et Reine Fabiola, Grand’Rue 3, 6000 Charleroi, Belgium
    • ,
  • D. Sartenaer

      Affiliations

    • Département de Génétique, Institut de Pathologie et de Génétique, Avenue Georges Lemaitre 25, 6041 Gosselies, Belgium
    • ,
  • S.F.E.H. Califice

      Affiliations

    • OncoMethylome Sciences SA, Tour 5 GIGA (B34), +3, Avenue de l’Hopital 11, B-4000 Liège, Belgium
    • ,
  • K. Bierau

      Affiliations

    • OncoMethylome Sciences SA, Tour 5 GIGA (B34), +3, Avenue de l’Hopital 11, B-4000 Liège, Belgium
    • ,
  • C. Svensson

      Affiliations

    • OncoMethylome Sciences SA, Tour 5 GIGA (B34), +3, Avenue de l’Hopital 11, B-4000 Liège, Belgium
    • ,
  • J. De Grève

      Affiliations

    • Medical Oncology, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    • ,
  • B. Neyns

      Affiliations

    • Medical Oncology, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    • Corresponding Author InformationCorresponding author: Tel.: +32 2 477 64 15; fax: +32 2 477 62 10.

Received 20 June 2008 ,Revised 15 August 2008 ,Accepted 5 September 2008.

  • Image Result

    Kaplan–Meier estimate of time to disease progression based on O6-methylguanine-DNA-methyltransferase promoter methylation status for all patients (panel A; n=38) and by histology (glioblastoma; n=22 [

    Kaplan–Meier estimate of time to disease progression based on O6-methylguanine-DNA-methyltransferase promoter methylation status for all patients (panel A; n=38) and by histology (glioblastoma; n=22 [panel B]; anaplastic astrocytoma/anaplastic oligoastrocytoma; n=16 [panel C]).

  • Image Result
    Kaplan–Meier estimate of overall survival from initiation of temozolomide for recurrent disease based on O6-methylguanine-DNA-methyltransferase promoter methylation status and by tumour histology (gli

    Kaplan–Meier estimate of overall survival from initiation of temozolomide for recurrent disease based on O6-methylguanine-DNA-methyltransferase promoter methylation status and by tumour histology (glioblastoma, n=22 [panel A]; anaplastic astrocytoma/anaplastic oligoastrocytoma, n=16 [panel B]).

  • Image Result
    Kaplan–Meier estimate of overall survival from diagnosis of high-grade glioma based on O6-methylguanine-DNA-methyltransferase promoter methylation status and by tumour histology (glioblastoma, n=32 [p

    Kaplan–Meier estimate of overall survival from diagnosis of high-grade glioma based on O6-methylguanine-DNA-methyltransferase promoter methylation status and by tumour histology (glioblastoma, n=32 [panel A]; anaplastic astrocytoma/anaplastic oligoastrocytoma, n=18; [panel B]).

PII: S0959-8049(08)00701-6

doi: 10.1016/j.ejca.2008.09.002

European Journal of Cancer
Volume 45, Issue 1 , Pages 146-153 , January 2009

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