European Journal of Cancer
Volume 45, Issue 1 , Pages 82-89, January 2009

Metabolic syndrome after risk-reducing salpingo-oophorectomy in women at high risk for hereditary breast ovarian cancer: A controlled observational study

  • Trond M. Michelsen

      Affiliations

    • Department of Gynaecology, Sørlandet Hospital Arendal, Service Box 605, N-4809 Arendal, Norway
    • National Resource Centre for Women’s Health, Rikshospitalet University Hospital, 0027 Oslo, Norway
    • Corresponding Author InformationCorresponding author. Address: Department of Gynaecology, Sørlandet Hospital Arendal, Service Box 605, N-4809 Arendal, Norway. Tel.: +47 37014000; fax: +47 37014041.
    • ,
  • Are H. Pripp

      Affiliations

    • Biostatistics Unit, Rikshospitalet University Hospital, 0027 Oslo, Norway
    • ,
  • Serena Tonstad

      Affiliations

    • Department of Internal Medicine, Ullevål University Hospital, University of Oslo Division, 0407 Oslo, Norway
    • ,
  • Claes G. Tropé

      Affiliations

    • Department of Gynaecologic Oncology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, University of Oslo Division, 0310 Oslo, Norway
    • ,
  • Anne Dørum

      Affiliations

    • Department of Gynaecologic Oncology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, University of Oslo Division, 0310 Oslo, Norway

Received 19 July 2008; received in revised form 12 September 2008; accepted 30 September 2008. published online 13 November 2008.

Abstract 

Surgical menopause may increase the risk of cardiovascular diseases (CVDs). The aim of this study was to determine the risk of metabolic syndrome in women who had undergone risk-reducing salpingo-oophorectomy (RRSO) because of increased risk of hereditary breast ovarian cancer (HBOC).

A sample of 326 (65% of invited) women at risk of HBOC who had undergone RRSO was compared to 679 women from the general population. Mean follow-up after surgery was 6.5 years (standard deviations [SD] 4.4). RRSO was significantly associated with metabolic syndrome according to the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria (odds ratio [OR] 2.46 [95% confidence interval (CI) 1.63, 3.73]) and according to the International Diabetes Federation criteria (OR 2.49 [CI 1.60, 3.88]), as were increasing age and body mass index (BMI).

RRSO in women at risk of HBOC is significantly associated with the metabolic syndrome, and the follow-up after RRSO should take these findings into consideration.

Keywords: Genes, BRCA1, Genes, BRCA2, Oophorectomy, Metabolic syndrome X, Cardiovascular diseases

 

PII: S0959-8049(08)00786-7

doi:10.1016/j.ejca.2008.09.028

European Journal of Cancer
Volume 45, Issue 1 , Pages 82-89, January 2009