European Journal of Cancer
Volume 45, Issue 1 , Pages 154-163 , January 2009

Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy

  • Takehiro Kawashiri

      Affiliations

    • Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Nobuaki Egashira

      Affiliations

    • Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author: Tel.: +81 92 642 5920; fax: +81 92 642 5937.
  • ,
  • Yoshinori Itoh

      Affiliations

    • Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194, Japan
  • ,
  • Takao Shimazoe

      Affiliations

    • Department of Pharmacoepidemiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Yoko Ikegami

      Affiliations

    • Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Takahisa Yano

      Affiliations

    • Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • ,
  • Megumu Yoshimura

      Affiliations

    • Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Ryozo Oishi

      Affiliations

    • Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Received 2 May 2008 ,Revised 26 September 2008 ,Accepted 6 October 2008.

References 

  1. Quasthoff S, Hartung HP. Chemotherapy-induced peripheral neuropathy. J Neurol. 2002;249:9–17
  2. Dougherty PM, Cata JP, Cordella JV, Burton A, Weng HR. Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain. 2004;109:132–142
  3. Lee JJ, Swain SM. Peripheral neuropathy induced by microtubule-stabilizing agents. J Clin Oncol. 2006;24:1633–1642
  4. Lorusso D, Ferrandina G, Greggi S, et al. Multicenter Italian Trials in Ovarian Cancer investigators. Phase III multicenter randomized trial of amifostine as cytoprotectant in first-line chemotherapy in ovarian cancer patients. Ann Oncol. 2003;14:1086–1093
  5. Stubblefield MD, Vahdat LT, Balmaceda CM, Troxel AB, Hesdorffer CS, Gooch CL. Glutamine as a neuroprotective agent in highdose paclitaxel-induced peripheral neuropathy: A clinical and electrophysiologic study. Clin Oncol (R Coll Radiol). 2005;17:271–276
  6. Bianchi G, Vitali G, Caraceni A, et al. Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. Eur J Cancer. 2005;41:1746–1750
  7. Takeda K, Negoro S, Matsui K. Phase I safety and pharmacokinetic trial of BNP7787 in patients receiving cisplatin (CDDP) and paclitaxel (PTX) for advanced non-small cell lung cancer (NSCLC): An Osaka phase I study group trial. Proc Am Soc Clin Oncol. 2002;21:114
  8. Argyriou AA, Chroni E, Koutras A, et al. Vitamin E for prophylaxis against chemotherapy-induced neuropathy: A randomized controlled trial. Neurology. 2005;64:26–31
  9. Bárdos G, Móricz K, Jaszlits L, et al. BGP-15, a hydroximic acid derivative, protects against cisplatin or taxol-induced peripheral neuropathy in rats. Toxicol Appl Pharmacol. 2003;190:9–16
  10. Siau C, Bennett GJ. Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy. Anesth Analg. 2006;102:1485–1490
  11. Matsumoto M, Inoue M, Hald A, Xie W, Ueda H. Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin. J Pharmacol Exp Ther. 2006;318:735–740
  12. Xiao W, Boroujerdi A, Bennett GJ, Luo ZD. Chemotherapy-evoked painful Peripheral neuropathy: analagesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. Neuroscience. 2007;144:714–720
  13. Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, Levine JD. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci. 2004;24:4444–4452
  14. Flatters SJL, Bennett GJ. Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain. 2006;122:245–257
  15. Peters CM, Jimenez-Andrade JM, Jonas BM, et al. Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells. Exp Neurol. 2006;203:42–54
  16. Ledeboer A, Jekich BM, Sloane EM, et al. Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun. 2006;21:686–698
  17. Siau C, Xiao W, Bennett GJ. Paclitaxel- and vincristine-evoked painful peripheral neuropathies: Loss of epidermal innervation and activation of Langerhans cells. Exp Neurol. 2006;201:507–514
  18. Sahenk Z, Barohn R, New P, Mendell JR. Taxol neuropathy: Electrodiagnostic and sural nerve biopsy findings. Arch Neurol. 1994;51:726–729
  19. New PZ, Jackson CE, Rinaldi D, Burris H, Barohn RJ. Peripheral neuropathy secondary to docetaxel (Taxotere). Neurology. 1996;46:108–111
  20. Fazio R, Quattrini A, Bolognesi A, et al. Docetaxel neuropathy: a distal axonopathy. Acta Neuropathol (Berl). 1999;98:651–653
  21. Kawamura M, Ohara H, Go K, Koga Y, Ienaga K. Neurotropin induces antinociceptive effect by enhancing descending pain inhibitory systems involving 5-HT3 and noradrenergic α2 receptors in spinal dorsal horn. Life Sci. 1998;62:2181–2190
  22. Flatters SJL, Bennett GJ. Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain. 2004;109:150–161
  23. Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F. Description of a short-term Taxol®-induced nociceptive neuropathy in rats. Brain Res. 2000;887:239–249
  24. Jeljeli M, Strazielle C, Caston J, Lalonde R. Effects of centrolateral or medial thalamic lesions on motor coordination and spatial orientation in rats. Neurosci Res. 2000;38:155–164
  25. Flatters SJL, Xiao WH, Bennett GJ. Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. Neurosci Lett. 2006;397:219–223
  26. Fritz IB, Yue KT. Long-chain carnitine acyltransferase and the role of acylcarnitine derivatives in the catalytic increase of fatty acid oxidation induced by carnitine. J Lipid Res. 1963;58:279–288
  27. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem. 1996;271:5768–5776
  28. Backonja M, Beydoun A, Edwards KR, et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA. 1998;280:1831–1836
  29. Gorson KC, Schott C, Herman R, Ropper AH, Rand WM. Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial. J Neurol Neurosurg Psychiatry. 1999;66:251–252
  30. Caraceni A, Zecca E, Bonezzi C, et al. Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. J Clin Oncol. 2004;22:2909–2917
  31. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA. 1998;280:1837–1842
  32. Dina OA, Chen X, Reichling D, Levine JD. Role of protein kinase Cε and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. Neuroscience. 2001;108:507–515
  33. Polomano RC, Mannes AJ, Clark US, Bennett GJ. A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel. Pain. 2001;94:293–304
  34. Cliffer KD, Siuciak JA, Carson SR, et al. Physiological characterization of taxol-induced large-fiber sensory neuropathy in the rat. Ann Neurol. 1998;43:46–55
  35. Wang MS, Davis AA, Culver DG, Wang Q, Powers JC, Glass JD. Calpain inhibition protects against Taxol-induced sensory neuropathy. Brain. 2004;127:671–679
  36. Wagner R, Heckman HM, Myers RR. Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent. Pain. 1998;77:173–179
  37. Wang MS, Davis AA, Culver DG, Glass JD. WldS mice are resistant to paclitaxel (taxol) neuropathy. Ann Neurol. 2002;52:442–447
  38. Nakamura K, Ono T, Nishijo H, Tamura R. Action of neurotropin on rat hypothalamic neurons in tissue slices. Brain Res Bull. 1990;24:811–817
  39. Hata T, Kita T, Kawabata A, Itoh E, Nishimura Y. Changes of tissue blood flow in mice loaded with SART (repeated cold) stress or restraint and water immersion stress and the effect of administered neurotropin. Jpn J Pharmacol. 1986;41:69–79
  40. Yoneda R, Kita T, Hata T, Namimatsu A. Experimental partial sympathicotonia, and effects of some drugs on it in restraint and water immersion stressed animals. J Pharmacobiodyn. 1980;3:692–701
  41. Hata T, Kita T, Higashiguchi T, Ichida S. Total acetylcholine content, and activities of choline acetyltransferase and acetylcholinesterase in brain and duodenum of SART-stressed (repeated cold-stressed) rat. Jpn J Pharmacol. 1986;41:475–485
  42. Tanaka M, Ida Y, Tsuda A, Tsujimaru S. Effects of neurotropin on regional brain noradrenaline metabolism in rats. Jpn J Pharmacol. 1989;49:187
  43. Hoshino Y, Nakamura T, Sato A, Mishima M, Yodoi J, Nakamura H. Neurotropin demonstrates cytoprotective effects in lung cells through the induction of thioredoxin-1. Am J Respir Cell Mol Biol. 2007;37:438–446
  44. Bai J, Nakamura H, Kwon YW, et al. Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells. J Neurosci. 2003;23:503–509
  45. Price SA, Gardiner NJ, Duran-Jimenez B, Zeef LA, Obrosova IG, Tomlinson DR. Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes. Brain Res. 2006;1116:206–214
  46. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004;279:30369–30374

PII: S0959-8049(08)00803-4

doi: 10.1016/j.ejca.2008.10.004

European Journal of Cancer
Volume 45, Issue 1 , Pages 154-163 , January 2009