European Journal of Cancer
Volume 45, Issue 10 , Pages 1831-1838, July 2009

Metabolic syndrome and risk of cancer mortality in men

  • Jason R. Jaggers

      Affiliations

    • Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, United States
    • Corresponding Author InformationCorresponding author: Tel.: +1 803 777 8421; fax: +1 803 708 5567.
    • ,
  • Xuemei Sui

      Affiliations

    • Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, United States
    • ,
  • Steven P. Hooker

      Affiliations

    • Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, United States
    • ,
  • Michael J. LaMonte

      Affiliations

    • Department of Social and Preventive Medicine, University of Buffalo, Buffalo, NY, United States
    • ,
  • Charles E. Matthews

      Affiliations

    • Vanderbilt University Medical Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Nashville, TN, United States
    • ,
  • Gregory A. Hand

      Affiliations

    • Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, United States
    • ,
  • Steven N. Blair

      Affiliations

    • Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, United States
    • Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States

Received 14 September 2008; received in revised form 22 January 2009; accepted 28 January 2009. published online 02 March 2009.

Abstract 

Background

Metabolic syndrome (MetS) has been linked with an increased risk of developing cancer; however, the association between MetS and cancer mortality remains less clear. Little research has focused on pre-cancer risk factors that may affect the outcome of treatment. The purpose of this study was to examine the association between MetS and all-cancer mortality in men.

Methods

The participants included 33,230 men aged 20–88 years who were enrolled in the Aerobics Centre Longitudinal Study and who were free of known cancer at the baseline.

Results

At baseline 28% of all the participants had MetS. During an average of 14 years follow-up, there were a total of 685 deaths due to cancer. MetS at baseline was associated with a 56% greater age-adjusted risk in cancer mortality.

Conclusion

These data show that MetS is associated with an increased risk of all-cause cancer mortality in men. Based on these findings, it is evident that successful interventions should be identified to attenuate the negative effects of MetS.

Keywords: Insulin resistance, Epidemiology, Hypertension, Obesity, Dyslipidaemia, Lung cancer, Colorectal cancer

 

PII: S0959-8049(09)00057-4

doi:10.1016/j.ejca.2009.01.031

European Journal of Cancer
Volume 45, Issue 10 , Pages 1831-1838, July 2009