European Journal of Cancer
Volume 45, Issue 18 , Pages 3254-3261 , December 2009

Associations of sexual dysfunction symptoms with PSA-detected localised and advanced prostate cancer: A case-control study nested within the UK population-based ProtecT (Prostate testing for cancer and Treatment) study

  • Simon M. Collin

      Affiliations

    • Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    • Corresponding Author InformationCorresponding author: Tel.: +44 0117 3313934; fax: +44 0117 9287292.
  • ,
  • Chris Metcalfe

      Affiliations

    • Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
  • ,
  • Jenny L. Donovan

      Affiliations

    • Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
  • ,
  • J. Athene Lane

      Affiliations

    • Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
  • ,
  • Michael Davis

      Affiliations

    • Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
  • ,
  • David E. Neal

      Affiliations

    • Department of Oncology, University of Cambridge, P.O. Box 279 (S4), Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
  • ,
  • Freddie C. Hamdy

      Affiliations

    • Nuffield Department of Surgery, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
  • ,
  • Richard M. Martin

      Affiliations

    • Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK

Received 23 March 2009 ,Revised 12 May 2009 ,Accepted 15 May 2009.

References 

  1. Villers A, McNeal JE, Redwine EA, Freiha FS, Stamey TA. The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol. 1989;142(3):763–768
  2. Harnden P, Shelley MD, Clements H, et al. The prognostic significance of perineural invasion in prostatic cancer biopsies: a systematic review. Cancer. 2007;109(1):13–24
  3. Collin SM, Metcalfe C, Donovan J, et al. Associations of lower urinary tract symptoms with prostate-specific antigen levels, and screen-detected localized and advanced prostate cancer: a case-control study nested within the UK population-based ProtecT (Prostate testing for cancer and Treatment) study. BJU Int. 2008;102(10):1400–1406
  4. Rosen RC, Giuliano F, Carson CC. Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Eur Urol. 2005;47(6):824–837
  5. Hamilton W, Sharp DJ, Peters TJ, Round AP. Clinical features of prostate cancer before diagnosis: a population-based, case-control study. Brit J Gen Pract. 2006;56(531):756–762
  6. Helgason AR, Adolfsson J, Dickman P, Arver S, Fredrikson M, Steineck G. Factors associated with waning sexual function among elderly men and prostate cancer patients. J Urol. 1997;158(1):155–159
  7. Korfage IJ, de Koning HJ, Essink-Bot ML. Response shift due to diagnosis and primary treatment of localized prostate cancer: a then-test and a vignette study. Qual Life Res. 2007;16(10):1627–1634
  8. Jakobsson L, Loven L, Hallberg IR. Sexual problems in men with prostate cancer in comparison with men with benign prostatic hyperplasia and men from the general population. J Clin Nurs. 2001;10(4):573–582
  9. Barry MJ. Screening for prostate cancer – the controversy that refuses to die. New Engl J Med. 2009;360(13):1351–1354
  10. Frankel SJ, Donovan JL, Peters TI, et al. Sexual dysfunction in men with lower urinary tract symptoms. J Clin Epidemiol. 1998;51(8):677–685
  11. Wei JT, Dunn RL, Litwin MS, Sandler HM, Sanda MG. Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology. 2000;56(6):899–905
  12. Lee IH, Roberts R, Shah RB, et al. Perineural invasion is a marker for pathologically advanced disease in localized prostate cancer. Int J Radiat Oncol Biol Phys. 2007;68(4):1059–1064
  13. Ayala GE, Dai H, Powell M, et al. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res. 2008;14(23):7593–7603
  14. Iguchi T, Wang CY, Delongchamps NB, et al. Occult prostate cancer effects the results of case-control studies due to verification bias. Anticancer Res. 2008;28(5B):3007–3010
  15. Katz DA, Jarrard DF, McHorney CA, et al. Health perceptions in patients who undergo screening and workup for prostate cancer. Urology. 2007;69(2):215–220
  16. Ben-Shlomo Y, Evans S, Ibrahim F, et al. The risk of prostate cancer amongst black men in the United Kingdom: the PROCESS cohort study. Eur Urol. 2008;53(1):99–105
  17. Rosen RC. Update on the relationship between sexual dysfunction and lower urinary tract symptoms/benign prostatic hyperplasia. Curr Opin Urol. 2006;16(1):11–19

PII: S0959-8049(09)00377-3

doi: 10.1016/j.ejca.2009.05.021

European Journal of Cancer
Volume 45, Issue 18 , Pages 3254-3261 , December 2009