European Journal of Cancer
Volume 45, Issue 17 , Pages 2977-2983 , November 2009

Comparison of dysplasia profiles in stimulated ovaries and in those with a genetic risk for ovarian cancer

  • J. Dauplat

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • G. Chene

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • Department of Obstetrics, Gynaecology and Reproductive Medicine, CHU St. Etienne, France
    • Corresponding Author InformationCorresponding author: Address: Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France. Tel.: +33 6 07 08 17 86; fax: +33 4 77 82 89 56.
    • ,
  • C. Pomel

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • M.M. Dauplat

      Affiliations

    • Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand, France
    • Department of Histopathology, CHU Clermont-Ferrand, France
    • ,
  • G.Le Bouëdec

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • F. Mishellany

      Affiliations

    • Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • N. Lagarde

      Affiliations

    • Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • Y.J. Bignon

      Affiliations

    • Department of Molecular Oncology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • P. Jaffeux

      Affiliations

    • Department of Medical Information, CHU Clermont-Ferrand, France
    • ,
  • B. Aublet-Cuvelier

      Affiliations

    • Department of Medical Information, CHU Clermont-Ferrand, France
    • ,
  • P. Dechelotte

      Affiliations

    • Department of Histopathology, CHU Clermont-Ferrand, France
    • ,
  • J.L. Pouly

      Affiliations

    • Department of Obstetrics, Gynaecology and Reproductive Medicine, CHU Clermont-Ferrand, France
    • ,
  • F. Penault-Llorca

      Affiliations

    • Department of Histopathology, Centre Jean Perrin, Clermont-Ferrand, France

Received 18 April 2009 ,Revised 9 June 2009 ,Accepted 12 June 2009.

References 

  1. Ahmed FY, Wiltshaw E, Ahern RP, et al. Natural history and prognosis of untreated stage I epithelial ovarian carcinoma. J Clin Oncol. 1996;14:2968–2975
  2. Menon U, Skates SJ, Lewis S, Rosenthal AN, Mc Donald N, Jacobs IJ. Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancer. J Clin Oncol. 2005;23:7919–7926
  3. Brewer MA, Ranger-Moore J, Baruche A, et al. Exploratory study of ovarian intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev. 2005;14:299–305
  4. Gwinn ML, Lee NC, Rhodes PH, Layde PM, Rubin GL. Pregnancy, breast feeding and oral contraceptives and the risk of epithelial ovarian cancer. J Clin Epidemiol. 1990;43:559–568
  5. Wu ML, Whittemore AS, Paffenbarger RS, et al. Personal and environmental characteristics related to epithelial ovarian cancer. Reproductive and menstrual events and oral contraceptive use. Am J Epidemiol. 1988;128:1216–1227
  6. Fathalla M. Incessant ovulation: a factor in ovarian neoplasia?. Lancet. 1971;2:163
  7. Deligdish L, Gil J, Kerner H, Wu HS, Beck D, Gershoni-Baruch R. Ovarian dysplasia in prophylactic oophorectomy specimens. Cancer. 1999;86:1544–1550
  8. Nieto JJ, Crow J, Sundaresan M, et al. Ovarian epithelial dysplasia in relation to ovulation induction and nulliparity. Gynecol Oncol. 2001;82:344–349
  9. Gusberg SB, Deligdish L. Ovarian dysplasia, a study of identical twins. Cancer. 1984;54:1–4
  10. Salazar H, Godwin AK, Daly MB, et al. Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies. J Natl Cancer Inst. 1996;88:1810–1820
  11. Plaxe S, Deligdish L, Dottino P, Cohen C. Ovarian intraepithelial neoplasia demonstrated in patients with stage I ovarian carcinoma. Gynecol Oncol. 1990;38:367–372
  12. Zheng J, Wan M, Zweizig S, Veliescu M, Yu MC, Dubeau L. Histologically benign or low grade malignant tumors adjacent to high grade ovarian carcinomas contain molecular characteristics of high grade carcinomas. Cancer Res. 1993;53:4138–4142
  13. Tressera F, Grases PJ, Labastida R, Ubeda A. Histological features of the controlateral ovary in patients with unilateral ovarian cancer: a case control study. Gynecol Oncol. 1998;71:437–441
  14. Mittal KR, Jacquotte AZ, Cooper JL, Demopoulos R. Controlateral ovary in unilateral ovarian carcinoma: a search for preneoplastic lesions. Int J Gynecol Pathol. 1993;12:59–63
  15. Werness BA, Afify AM, Bielat KL, Eltabbakh GH, Piver MS, Paterson JM. Altered surface and cyst epithelium of ovaries removed prophylactically from women with a family history of ovarian cancer. Hum Pathol. 1999;30:151–157
  16. Stratton JF, Buckey CH, Lowe D, Ponder BAJ. Comparison of prophylactic oophorectomy specimens from carriers and non carriers of a BRCA1 or BRCA2 gene mutation. J Natl Cancer Inst. 1999;91:626–681
  17. Barakat RR, Federici MG, Saigo PE, Robson ME, Offit K, Boyd J. Absence of premalignant histologic, molecular, or cell biologic alterations in prophylactic oophorectomy specimen from BRCA1 heterozygotes. Cancer. 2000;89:383–390
  18. Chene G, Penault-Llorca F, Le Bouëdec G, et al. Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk. Int J Gynecol Cancer. 2009;19:65–72
  19. Schloosshauer PW, Cohen CJ, Penault-Lllorca F, et al. Prophylactic oophorectomy. Cancer. 2003;98:2599–2606
  20. Deligdisch L, Gil J. Characterization of ovarian dysplasia by interactive morphometry. Cancer. 1989;63:748–755
  21. Deligdisch L, Miranda C, Barba J, Gil J. Ovarian dysplasia: nuclear texture analysis. Cancer. 1993;72:3253–3257
  22. Berchuck A, Kohler MF, Boente MP, Rodriguez GC, Whitaker RS, Bast RC. Growth regulation and transformation of ovarian epithelium. Cancer. 1993;71:545–551
  23. Wong AST, Maines-Bandiera SL, Rosen B, et al. Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: influence of family history of ovarian cancer. Int J Cancer. 1999;81:180–188
  24. Wong AST, Auersperg N. Ovarian surface epithelium: family history and early events in ovarian cancer. Reprod Biol Endoc. 2003;70:1–8
  25. Tok EC, Ertung D, Tataroglu C, Yazici G, Kanat H, Dilek S. Clinicopathologic study of the putative precursor lesions of epithelial ovarian cancer in low-risk women. Int J Gynecol Cancer. 2006;16:501–506
  26. Corakci A, Filiz S, Caliskan E, Dalcik C, Ozeren S, Dalcik H. The effects of ovulation induction on ovarian epithelium dysplasia scores and Ki67 expression: an experimental study on rats. Int J Gynecol Cancer. 2005;15:866–871
  27. Whittemore AS, Harris R, Itnyre J. And the collaborative Ovarian Cancer Group. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 case-control studies. II. Invasive epithelial ovarian cancer in white women. Am J Epidemiol. 1992;136:1184–1202
  28. Harris R, Whittemore AS, Itnyre J. And the collaborative Ovarian Cancer Group. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 case-control studies. III. Epithelial tumors of low malignant potential in white women. Am J Epidemiol. 1992;136:1204–1211
  29. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG. Ovarian tumors in a cohort of infertile women. N Engl J Med. 1994;331:771–776
  30. Chene G, Penault-Llorca F, Le Bouëdec G, et al. Ovarian epithelial dysplasia after ovulation induction: time and dose effect. Human Reprod. 2009;24:132–138
  31. Kurman RJ, Shih IeM. Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications. Int J Gynecol Pathol. 2008;27:151–160
  32. Dehari R, Kurman RJ, Logani S, Shih IeM. The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. Am J Surg Pathol. 2007;31:1007–1012
  33. Folkins AK, Jarboe EA, Roh MH, Crum CP. Precursors to pelvic serous carcinoma and their clinical implications. Gynecol Oncol. 2009;113:391–396
  34. Crum CP, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res. 2007;5:35–44
  35. Carcangiu ML, Radice P, Manoukian S, et al. Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy from BRCA1 and BRCA2 germline mutation carriers. Int J Gynecol Pathol. 2004;23:35–40
  36. Mahdavi A, Pejovic T, Nezhat F. Induction of ovulation and ovarian cancer: a critical review of the literature. Fertil Steril. 2006;85:819–826
  37. Ness RB, Cramer DW, Goodman MT. Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies. Am J Epidemiol. 2002;155:217–224
  38. Shushan A, Paltiel O, Iscovich J, Elchalal U, Peretz Y, Schenker JG. Human menopausal gonadotrophin and risk of epithelial ovarian cancer. Fertil Steril. 1996;65:13–18
  39. Parazzini F, Negri E, La Vecchia C, et al. Treatment for infertility and risk of ovarian tumors of borderline malignancy. Gynecol Oncol. 1998;68:226–228
  40. Sushan A, Paltiel O, Schencker JG. Induction of ovulation and borderline ovarian cancer-the hormonal connection?. Eur J Obstet Gynecol Reprod Biol. 1999;85:1–4
  41. Cinton GM, Hua W. Estrogen action in human ovarian cancer. Crit Rev Oncol Hematol. 1997;25:1–9
  42. Garg PP, Kerlikowske K, Subak L, Grady D. Hormone replacement therapy and the risk of epithelial ovarian cancer: a meta-analysis. Obstet Gynecol. 1998;92:472–479
  43. Chene G, Penault-Llorca F, Le Bouëdec G, et al. Ovarian epithelial dysplasia: myth or reality?. Review Gynecol Obstet Fertil. 2008;36:800–807
  44. Jongsma APM, Piek JMJ, Zweemer RP, et al. Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer. J Clin Pathol Mol Pathol. 2002;55:305–309

PII: S0959-8049(09)00458-4

doi: 10.1016/j.ejca.2009.06.012

European Journal of Cancer
Volume 45, Issue 17 , Pages 2977-2983 , November 2009

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