European Journal of Cancer
Volume 45, Issue 17 , Pages 3035-3041 , November 2009

Sequential high-dose chemotherapy for children with metastatic rhabdomyosarcoma

  • Gianni Bisogno

      Affiliations

    • Division of Haematology/Oncology, Department of Paediatrics, University Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy
    • Corresponding Author InformationCorresponding author: Tel.: +39 049 8211481; fax: +39 049 8213510.
    • ,
  • Andrea Ferrari

      Affiliations

    • Paediatric Oncology Unit, Istituto Nazionale Tumori, Via Giacomo Venezian 1, 20133 Milano, Italy
    • ,
  • Arcangelo Prete

      Affiliations

    • Oncology-Haematology and Cell Therapy Unit, Paediatrics Department, Via Massarenti 11, 40138 Bologna, Italy
    • ,
  • Chiara Messina

      Affiliations

    • Division of Haematology/Oncology, Department of Paediatrics, University Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy
    • ,
  • Eleonora Basso

      Affiliations

    • Division of Paediatric Haematology/Oncology, Piazza Polonia 94, 10126 Torino, Italy
    • ,
  • Giovanni Cecchetto

      Affiliations

    • Paediatric Surgery, Department of Paediatrics, Padova University Hospital, Via Giustiniani 3, 35128 Padova, Italy
    • ,
  • Paolo Indolfi

      Affiliations

    • Paediatric Oncology Service, Paediatric Department II, University of Napoli, Via S. Andrea delle Dame 4, 80138 Napoli, Italy
    • ,
  • Giovanni Scarzello

      Affiliations

    • Radiotherapy Division, Istituto Oncologico Veneto, Via Gattamelata 64, 35218 Padova, Italy
    • ,
  • Paolo D’Angelo

      Affiliations

    • Paediatric Oncology Unit, ‘G. Di Cristina’ Children’s Hospital, Via Benedettini 1, 90134, Palermo, Italy
    • ,
  • Luigi De Sio

      Affiliations

    • Division of Paediatric Oncology, Bambin Gesù Hospital, Piazza S. Onofrio 4, 00165 Roma, Italy
    • ,
  • Andrea Di Cataldo

      Affiliations

    • Paediatric Haematology and Oncology Unit, University of Catania, Via S. Sofia 78, 95123, Catania, Italy
    • ,
  • Modesto Carli

      Affiliations

    • Division of Haematology/Oncology, Department of Paediatrics, University Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy

Received 11 June 2009 ,Revised 7 August 2009 ,Accepted 20 August 2009.

References 

  1. Carli M, Colombatti R, Oberlin O, et al. European Intergroup Studies (MMT4–89 and MMT4–91) on childhood metastatic rhabdomyosarcoma: final results and analysis of prognostic factors. J Clin Oncol. 2004;22(23):4787–4794
  2. Breneman JC, Lyden E, Pappo AS, et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma - a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 2003;21(1):78–84
  3. Weigel BJ, Breitfeld PP, Hawkins D, Crist WM, Baker KS. Role of high-dose chemotherapy with hematopoietic stem cell rescue in the treatment of metastatic or recurrent rhabdomyosarcoma. J Pediatr Hematol Oncol. 2001;23(5):272–276
  4. Matthay KK, Villablanca JG, Seeger RC, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children’s Cancer Group. N Engl J Med 1999;341(16):165–173.
  5. Carli M, Colombatti R, Oberlin O, et al. High-dose melphalan with autologous stem-cell rescue in metastatic rhabdomyosarcoma. J Clin Oncol. 1999;17(9):2796–2803
  6. Koscielniak E, Rodary C, Flamant F, et al. Metastatic rhabdomyosarcoma and histologically similar tumors in childhood: a retrospective European multicentre analysis. Med Pediatr Oncol. 1992;20(3):209–214
  7. Frascella E, Pritchard-Jones K, Modak S, et al. Response of previously untreated metastatic rhabdomyosarcoma to combination chemotherapy with carboplatin, epirubicin and vincristine. Eur J Cancer. 1996;32A(5):821–825
  8. Bisogno G, Ferrari A, Bergeron C, et al. The IVADo regimen - a pilot study with ifosfamide, vincristine, actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study on behalf of the European pediatric Soft tissue sarcoma Study Group. Cancer. 2005;103(8):1719–1724
  9. Oberlin O, Rey A, Lyden E, et al. Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups. J Clin Oncol. 2008;26(14):2384–2389
  10. Crist W, Gehan EA, Ragab AH, et al. The Third Intergroup Rhabdomyosarcoma Study. J Clin Oncol. 1995;13(3):610–630
  11. Lager JJ, Lyden ER, Anderson JR, et al. Pooled analysis of phase II window studies in children with contemporary high-risk metastatic rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. J Clin Oncol. 2006;24(21):3415–3422
  12. Horowitz ME, Kinsella TJ, Wexler LH, et al. Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing’s sarcoma and rhabdomyosarcoma. J Clin Oncol. 1993;11(10):1911–1918
  13. Koscielniak E, Klingelbiel TH, Peters C, et al. Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report from the German/Austrian Pediatric Bone Marrow Transplantation Group. Bone Marrow Transplant. 1997;19(3):227–231
  14. Boulad F, Kernan N, LaQuaglia M, et al. High dose induction chemoradiotherapy followed by autologous bone marrow transplantation as consolidation therapy in rhabdomyosarcoma, extraosseous Ewing’s sarcoma and undifferentiated sarcoma. J Clin Oncol. 1998;16(5):1697–1706
  15. Williams BA, Williams KM, Doyle J, et al. Metastatic rhabdomyosarcoma: a retrospective review of patients treated at the hospital for sick children between 1989 and 1999. J Pediatr Hematol Oncol. 2004;26(4):243–247
  16. Lucidarme N, Valteau-Couanet D, Oberlin O, et al. Phase II study of high-dose thiotepa and hematopoietic stem cell transplantation in children with solid tumors. Bone Marrow Transplant. 1998;22(6):535–540
  17. Pession A, Prete A, Locatelli F, et al. Phase I study of high-dose thiotepa with busulfan, etoposide, and autologous stem cell support in children with disseminated solid tumors. Med Pediatr Oncol. 1999;33(5):450–454
  18. Prete A, Rondelli R, Paolucci P, et al. Sequential high dose chemotherapy (SHDC) with peripheral stem cell (PSC) support in resistant or relapsing childhood solid tumours (ST). Bone Marrow Transplant. 1999;238(suppl 1):S192
  19. McDowell H, Foot A, Bergeron C, et al. Metastatic rhabdomyosarcoma report: SIOP trial MMT98. Pediatr Blood Cancer. 2005;45(4):411
  20. Klingebiel T, Boos J, Beske F, et al. Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial. Pediatr Blood Cancer. 2008;50(4):739–745
  21. Anderson JR, Ruby E, Lin M et al: Identification of a favorable subset of patients (pts) with metastatic (MET) rhabdomyosarcoma (RMS): A report from the Intergroup Rhabdomyosarcoma Study Group (IRSG). Proc Am Soc Clin Oncol 16:1836, 1997 (abstr).

PII: S0959-8049(09)00654-6

doi: 10.1016/j.ejca.2009.08.019

European Journal of Cancer
Volume 45, Issue 17 , Pages 3035-3041 , November 2009

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