ONCOPOOL – A European database for 16,944 cases of breast cancer
Received 9 June 2009; received in revised form 9 July 2009; accepted 9 September 2009. published online 07 October 2009.
Abstract
ONCOPOOL is a retrospectively compiled database of primary operable invasive breast cancers treated in the 1990s in 10 European breast cancer Units. Sixteen thousand and nine hundred and forty four cases were entered, with tumours less than 5cm diameter in women aged 70 or less (mean age 55).
Data
Data were date of birth, mode of diagnosis, pathology (size, lymph node status, grade, type, lympho-vascular invasion and hormone receptor) and therapies and outcome measures: first local, regional or distant recurrences, contralateral primary, date and cause of death.
Tumour characteristics
Mean diameter 1.8cm, 66% lymph node negative, 24% 1–3 lymph nodes involved and 10% had 4 or more involved. Grade 1, 29%; Grade 2, 41%; and Grade 3, 30%. Polynomial relationships were established between grade, stage and size.
Seventy-five percent were oestrogen receptor (ER) positive. ER closely related to grade.
Outcomes
Overall Survival was 89% at 5years from diagnosis, 80% 10years and 73% 15years; Breast Cancer-Specific survivals were 91%, 84% and 79%.
Survival strongly related to the Nottingham Prognostic Index (NPI).
Cases detected at screening had 84% 10-year survival, those presenting symptomatically 76%.
ER positive cases treated with adjuvant hormone therapy had a reduction in risk of death of 13% over those not receiving adjuvant therapy (p=0.000). ER negative cases treated with chemotherapy showed a risk reduction of 23% over those not receiving chemotherapy (p=0.000).
ABSTRACT