European Journal of Cancer
Volume 46, Issue 2 , Pages 332-339 , January 2010

HMGA1 protein expression in familial breast carcinoma patients

  • Gennaro Chiappetta

      Affiliations

    • Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, Italy
    • Corresponding Author InformationCorresponding author: Address: Istituto Nazionale dei Tumori, Fondazione Pascale, via Mariano Semmola, 80131 Naples, Italy. Tel./fax: +39 081 5903840.
  • ,
  • Alessandro Ottaiano

      Affiliations

    • Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, Italy
  • ,
  • Emilia Vuttariello

      Affiliations

    • Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, Italy
  • ,
  • Mario Monaco

      Affiliations

    • Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, Italy
  • ,
  • Francesca Galdiero

      Affiliations

    • Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, Italy
  • ,
  • Adolfo Gallipoli

      Affiliations

    • Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, Italy
  • ,
  • Silvana Pilotti

      Affiliations

    • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • ,
  • Giovanna Jodice

      Affiliations

    • Fondazione IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy
  • ,
  • Manoukian Siranoush

      Affiliations

    • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • ,
  • Mara Colombo

      Affiliations

    • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • ,
  • Carla B. Ripamonti

      Affiliations

    • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • ,
  • Pier Lorenzo Pallante

      Affiliations

    • Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, Naples, Italy
  • ,
  • Paolo Radice

      Affiliations

    • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    • Fondazione IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy
  • ,
  • Alfredo Fusco

      Affiliations

    • Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II”, Naples, Italy

Received 3 June 2009 ,Revised 2 October 2009 ,Accepted 9 October 2009.

References 

  1. Claus EB, Risch N, Thompson WD. Genetic analysis of breast cancer in the cancer and steroid hormone study. Am J Hum Genet. 1991;48:232–242
  2. Narod S, Ford D, Devilee P, et al. Genetic heterogeneity of breast–ovarian cancer revisited. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995;57:957–958
  3. Peto J, Collins N, Barfoot R, et al. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst. 1999;91:943–949
  4. Marcus JN, Watson P, Page DL, et al. Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer. 1996;77:697–709
  5. Marcus JN, Watson P, Page DL, et al. BRCA2 hereditary breast cancer pathophenotype. Breast Cancer Res Treat. 1997;44:275–277
  6. Armes JE, Egan AJ, Southey MC, et al. The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study. Cancer. 1998;83:2335–2345
  7. Grosschedl R, Giese K, Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet. 1994;10:94–100
  8. Reeves R, Nissen MS. The A–T–DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J Biol Chem. 1990;265:8573–8582
  9. Reeves R. Structure and function of the HMGI(Y) family of architectural transcription factors. Environ Health Perspect. 2000;108:803–809
  10. Chiappetta G, Avvantaggiato V, Visconti R, et al. High level expression of the HMGA1 gene during embryonic development. Oncogene. 1996;13:2439–2446
  11. Abe N, Watanabe T, Masaki T, et al. Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins. Cancer Res. 2000;60:3117–3122
  12. Chiappetta G, Tallini G, De Biasio MC, et al. Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res. 1998;58:4193–4198
  13. Chiappetta G, Manfioletti G, Pentimalli F, et al. High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases. Int J Cancer. 2001;91:147–151
  14. Chiappetta G, Botti G, Monaco M, et al. HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. Clin Cancer Res. 2004;10:7637–7644
  15. Meyer B, Loeschke S, Schultze A, et al. HMGA2 overexpression in non-small cell lung cancer. Mol Carcinogen. 2007;46:503–511
  16. Masciullo V, Baldassarre G, Pentimalli F, et al. HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas. Carcinogenesis. 2003;24:1191–1198
  17. Tamimi Y, Vander Poel HG, Denyn MM, et al. Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization. Cancer Res. 1993;53:5512–5516
  18. Miyazawa J, Mitoro A, Kawashiri S, Chada KK, Imai K. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res. 2004;15:2024–2029
  19. Rho YS, Lim YC, Park IS, et al. High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma. Acta Otolaryngol. 2007;127:76–81
  20. Abe N, Watanabe T, Izumisato Y, et al. High mobility group A1 is expressed in metastatic adenocarcinoma to the liver and intrahepatic cholangiocarcinoma, but not in hepatocellular carcinoma: its potential use in the diagnosis of liver neoplasms. J Gastroenterol. 2003;38:1144–1149
  21. Berlingieri MT, Manfioletti G, Santoro M, et al. Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Mol Cell Biol. 1995;15:1545–1553
  22. Wood LJ, Maher JF, Bunton TE, Resar LM. The oncogenic properties of the HMG-I gene family. Cancer Res. 2000;60(15):4256–4261
  23. Baldassarre G, Battista S, Belletti B, et al. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. Mol Cell Biol. 2003;23:2225–2238
  24. Manoukian S, Peissel B, Pensotti V, et al. Germline TP53 and BRCA2 mutations in breast cancer/sarcoma families. Eur J Cancer. 2007;43:601–606
  25. Wagner TM, Moslinger RA, Muhr D, et al. BRCA1-related breast cancer in Austrian breast and ovarian cancer families: specific BRCA1 mutations and pathological characteristics. Int J Cancer. 1998;77:354–360
  26. Wagner TM, Hirtenlehner K, Shen P, et al. Global sequence diversity of BRCA2: analysis of 71 breast cancer families and 95 control individuals of worldwide populations. Hum Mol Genet. 1999;8:413–423
  27. Colombo M, Giarola M, Mariani L, et al. Cyclin D1 expression analysis in familial breast cancers may discriminate BRCAX from BRCA2-linked cases. Mod Pathol. 2008;21(10):1262–1270
  28. Chiappetta G, Bandiera A, Berlingieri MT, et al. The expression of the high mobility group HMGI(Y) proteins correlates with the malignant phenotype of human thyroid neoplasms. Oncogene. 1995;10:1307–1314
  29. Fedele M, Pentimalli F, et al. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene. 2005;24(21):3427–3435
  30. Fedele M, Fidanza V, Battista S, et al. Aploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res. 2006;66(5):2536–2543

PII: S0959-8049(09)00762-X

doi: 10.1016/j.ejca.2009.10.015

European Journal of Cancer
Volume 46, Issue 2 , Pages 332-339 , January 2010