European Journal of Cancer
Volume 46, Issue 4 , Pages 800-810 , March 2010

Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia

  • Olga Grzybowska-Izydorczyk

      Affiliations

    • Department of Experimental Haematology, Medical University of Lodz, Copernicus Memorial Hospital, Ciolkowskiego 2, 93-510 Lodz, Poland
    • ,
  • Barbara Cebula

      Affiliations

    • Department of Experimental Haematology, Medical University of Lodz, Copernicus Memorial Hospital, Ciolkowskiego 2, 93-510 Lodz, Poland
    • ,
  • Tadeusz Robak

      Affiliations

    • Department of Haematology, Medical University of Lodz, Lodz, Poland
    • ,
  • Piotr Smolewski

      Affiliations

    • Department of Experimental Haematology, Medical University of Lodz, Copernicus Memorial Hospital, Ciolkowskiego 2, 93-510 Lodz, Poland
    • Corresponding Author InformationCorresponding author: Tel.: +48 42 689 51 91; fax: +48 42 689 51 92.

Received 20 May 2009 ,Revised 22 September 2009 ,Accepted 25 November 2009.

References 

  1. Rai KR, Wasil T, Iqbal U, Driscoll N, Janson D, Mehrotra B. Clinical staging and prognostic markers in chronic lymphocytic leukemia. Hematol Oncol Clin North Am. 2004;18:795–805
  2. Caligaris-Cappio F. Biology of chronic lymphocytic leukemia. Rev Clin Exp Hematol. 2000;4:5–21
  3. Collins RJ, Verschuer LA, Harmon BV, Prentice RL, Pope JH, Kerr JF. Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br J Haematol. 1989;71:343–350
  4. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001;26:61–66
  5. Campàs C, Cosialls AM, Barragán M, et al. Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Exp Hematol. 2006;34:1663–1669
  6. Kitada S, Andersen J, Akar S, et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood. 1998;91:3379–3389
  7. Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia. 1996;10:456–459
  8. Bellosillo B, Villamor N, López-Guillermo A, et al. Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Blood. 2002;100:1810–1816
  9. Vousden KH, Lu X. Live or let die: the cell’s response to p53. Nat Rev Cancer. 2002;2:594–604
  10. Cordone I, Masi S, Mauro FR, et al. P53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. Blood. 1998;91:4342–4349
  11. Deveraux QL, Reed JC. IAP family proteins–supressors of apoptosis. Genes Dev. 1999;13:239–252
  12. Verhagen AM, Coulson EJ, Vaux DL. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol. 2001;2:3009.1–3009.10
  13. Voux DL, Silke J. Mammalian mitochondrial IAP binding proteins. Biochem Biophys Res Comm. 2003;304:499–504
  14. Wrzesien-Kus A, Smolewski P, Sobczak-Pluta A, Wierzbowska A, Robak T. The inhibitor of apoptosis protein family and its antagonists in acute leukemias. Apoptosis. 2004;9:705–715
  15. Badran A, Yoshida A, Ishikawa K, et al. Identification of a novel splice variant of the human anti-apoptosis gene surviving. Biochem Biophys Res Commun. 2004;13:902–907
  16. Roy N, Deveraux Q, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. The EMBO Journal. 1997;16:6914–6925
  17. Eckelman B, Salvesen G, Scott F. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Reports. 2006;7:988–994
  18. Jia L, Patwari Y, Kelsey SM, et al. Role of Smac in human leukaemic cell apoptosis and proliferation. Oncogene. 2003;22:1589–1599
  19. Cilenti L, Lee Y, Hess S, et al. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. J Biol Chem. 2003;278:11489–11494
  20. Yin W, Cheepala S, Clifford JL. Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1. Biochem Biophys Res Commun. 2006;339:1148–1154
  21. Tamm I, Kornblau SM, Segall H, et al. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000;6:1796–1803
  22. Hofmann HS, Simm A, Hammer A, Silber RE, Bartling B. Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer. Cancer Res Clin Oncol. 2002;128:554–560
  23. Kleinberg L, Lie AK, Flørenes VA, Nesland JM, Davidson B. Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma. Hum Pathol. 2007;38:986–994
  24. Tamm I, Richter S, Scholz F, et al. High expression levels of X-linked inhibitor of apoptosis protein and survivin corelate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res. 2004;10:3737–3744
  25. Troeger A, Siepermann M, Escherich G, et al. Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia. Hematologica. 2007;92:1043–1050
  26. Yamamoto K, Abe S, Nakagawa Y, et al. Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia. Leuk Res. 2004;28:1203–1211
  27. Schlette EJ, Medeiros J, Goy A, Lai R, Rassidakis Z. Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma. Clin Oncol J. 2004;22:1682–1688
  28. Adida C, Haioun C, Gaulard P, et al. Prognostic significance of survivin expression in diffuse large B-cell lymphomas. Blood. 2000;96:1921–1925
  29. Schliep S, Decker T, Schneller F, Wagner H, Hacker G. Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia. Exp Hematol. 2004;32:556–562
  30. Nakagawa Y, Yamaguchi S, Hasegawa M, et al. Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia. Leuk Res. 2004;28:487–494
  31. de Graaf AO, van Krieken JH, Tönnissen E, et al. Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies. Br J Haematol. 2005;130:852–859
  32. Silva KL, Vasconcellos DV, Castro ED, Coelho AM, Linden R, Maia RC. Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia. Apoptosis. 2006;11:277–285
  33. Cheson BD, Bennet JM, Grever M, Kay N. National Cancer Institute Sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990–4997
  34. Rai KR, Stwitsky A, Cronkie E, Chonana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46:219–234
  35. Letestu R, Rawstron A, Ghia P, et al. Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: a multicentric international harmonization process. XI International Workshop on CLL, New York, September 16–18 2005. Leuk Lymphoma. 2005;46(Suppl. 1):S47
  36. Akyurek N, Ren Y, Rassidakis GZ, Schlette EJ, Medeiros LJ. Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas. Cancer. 2006;107:1844–1851
  37. Munzert G, Kirchner D, Stobbe H, et al. Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Blood. 2002;100:3749–3756
  38. Carter BZ, Milella M, Altieri DC, Andreeff M. Cytokine-regulated expression of survivin in myeloid leukemia. Blood. 2001;97:2784–2790
  39. Che XF, Zheng CL, Owatari S, et al. Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulaing survivin expression in ATL cell lines. Blood. 2006;107:4880–4887
  40. Martinez A, Bellosillo B, Bosch F, et al. Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol. 2004;164:501–510
  41. Granziero L, Ghia P, Circosta P, et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood. 2001;97:2777–2783
  42. Yan Y, Mahotka C, Heikaus S, et al. Disturbed balance of expression between XIAP and Smac/DIABLO during tumor progression in renal cell carcinomas. Br J Cancer. 2004;91:1349–1357
  43. Ren Y, Akyurek N, Schlette E, Rassidakis GZ, Medeiros LJ. Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas. Hum Pathol. 2006;37:1407–1413

☆ The data were presented at an oral session at the 50th Annual Meeting of the American Society of Haematology, San Francisco, December 6–9, 2008.

PII: S0959-8049(09)00877-6

doi: 10.1016/j.ejca.2009.11.023

European Journal of Cancer
Volume 46, Issue 4 , Pages 800-810 , March 2010

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