European Journal of Cancer
Volume 46, Issue 4 , Pages 697-702 , March 2010

From cancer patients to cancer survivors: The issue of Cardioncology – A biological perspective

  • Alberto Zambelli

      Affiliations

    • Fondazione IRCCS Salvatore Maugeri, Pavia, Italy
  • ,
  • Matteo Della Porta

      Affiliations

    • Universita’ degli Studi di Pavia, Pavia, Italy
  • ,
  • Vittorio Rosti

      Affiliations

    • Laboratorio di Epidemiologia Clinica, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 19, Pavia, Italy
    • Corresponding Author InformationCorresponding author: Tel.: +39 0382 502162; fax +39 0382 526223.

Received 25 September 2009 ,Revised 26 November 2009 ,Accepted 2 December 2009.

References 

  1. Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F. Capocaccia R; EUROCARE Working Group. EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer. 2009;45:931–991
  2. Carver JR, Shapiro CL, Ng A, et al. For the ASCO Cancer Survivorship expert panel. American Society of Clinical Oncology clinical evidence review of the ongoing care of adult cancer survivors: cardiac and pulmonary late effects. J Clin Oncol. 2007;25:3991–4008
  3. Jensen BV. Cardiotoxic consequences of anthracycliune-containing therapy in patients with breast cancer. Semin Oncol. 2006;33:S15–S21
  4. Chen MH, Kerkelä R, Force T. Mechanism of cardiac dysfunction associated with tyrosin kinase inhibitor cancer therapeutics. Circulation. 2008;118:84–95
  5. Gianni L, Herman EH, Lipshultz SE, Minotti G, Sarvazyan N, Sawyer DB. Anthracycline cardiotoxicity: from bench to bedside. J Clin Oncol. 2008;26:3777–3784
  6. Daher IN, Yeh TH. Vascular complications of selected cancer therapies. Nat Clin Pract Cardiovasc Med. 2008;5:797–805
  7. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;2759(5302):964–967
  8. Heil M, Eitenmuller I, Schmitz-Rixen T, Schaper W. Arteriogenesis versus angiogenesis: similarities and differences. J Cell Mol Med. 2006;10:45–55
  9. Liew A, Barry F, O’Brien T. Endothelial progenitor cells: diagnostic and therapeutic considerations. Bioessays. 2006;28:261–270
  10. Case J, Mead LE, Besler WK, et al. Human CD34+, AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. J Exp Hematol. 2007;35:1109–1118
  11. Mancuso P, Antoniotti P, Quarna J, et al. Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses. Clin Cancer Res. 2009;15:267–273
  12. Hill JM, Zakos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New Engl J Med. 2003;348:593–600
  13. Yoder MC, Mead LE, Prater D, et al. Re-defining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood. 2007;109:1801–1809
  14. Piaggio G, Rosti V, Corselli M, et al. Endothelial colony forming cells from patients with chronic myeloproliferative disorders lack the disease-specific molecular clonality marker. Blood. 2009;114:3127–3130
  15. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res. 2004;95:343–353
  16. Rehman J, Li J, Orschell CM, March KL. Peripheral blood ‘endothelial progenitor cells’ are derived from monocyte/macrophages and secrete angiogenic factors. Circulation. 2003;107:1164–1169
  17. Kalka C, Masuda H, Takahashi T, et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA. 2000;97:3422–3427
  18. Prokopi M, Pula G, Mayr U, et al. Proteomic amalysis reveals the presence of platelet microparticles in endothelial progenitor cell cultures. Blood. 2009;114:723–732
  19. Assmus B, Schachinger V, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation. 2002;106:3009–3017
  20. Assmus B, Honold J, Schachinger V, et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med. 2006;355:1222–1232
  21. Ingram DA, Mead LE, Tanaka H, et al. Identification of a novel hyerarchy of endothelial progenitor cells using human peripheral and umilical cord blood. Blood. 2004;104:2752–2760
  22. Reinisch A, Hofmann NA, Obenauf AC, et al. Humanized large-scale expanded endothelial colony–forming cells function in vitro and in vivo. Blood. 2009;113:6716–6725
  23. Yoon CH, Hur J, Park KW, et al. Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases. Circulation. 2005;112:1618–1627
  24. Sieveking DP, Buckle A, Celermajer DS, Ng MKC. Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insight from a novel human angiogenesis assay. J Am Coll Cardiol. 2008;51:660–668
  25. Ziegelhoeffer T, Fernandez B, Kostin S, et al. Bone marrow derived cells do not incorporate into the adult growing vasculature. Circ Res. 2004;94:230–238
  26. Grunewald M, Avraham I, Dor Y, et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accesory cell. Cell. 2006;124:175–189
  27. Hanahan D, Folkman J. Pattern and emerging mechanism of the angiogenic switch during tumourigenesis. Cell. 1996;86:353–364
  28. Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. 2008;319:195–198
  29. Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone marrow-derived endothelial and hematopoietic precursors blocks tumour angiogenesis and growth. Nature Med. 2001;7:1194–1201
  30. Nolan DJ, Ciarrocchi A, Mellick AS, et al. Bone marrow derived endothelial progenitor cells are a major determinant of nascent tumour vascularization. Genes Dev. 2007;21:1546–1558
  31. Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR-1 positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820–827
  32. Ingram DA, et al. Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood. 2005;105:2783–2786
  33. Ergün S, Hohn HP, Kilic N, Singer BB, Tilki D. Endothelial and hematopoietic progenitor cells (EPC and HPC): hand in hand fate determining partners for cancer cells. Stem Cell Rev. 2008;4:169–177
  34. Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer. 2008;8:618–631
  35. De Palma M, Venneri MA, Roca C, Naldini L. Targeting exogenous genes to tumour angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med. 2003;9:789–795
  36. Gothert JR, et al. Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumour endothelium. Blood. 2004;104:1769–1777
  37. Purhonen S, Palm J, Rossi D, et al. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumour growth. Proc Natl Acad Sci USA. 2008;105:6620–6625
  38. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70
  39. Bertolini F, Shaked Y, Mancuso P, Kerbel RS. The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer. 2006;6:835–845
  40. Maniotis AJ, Folberg R, Hess A, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol. 1999;155:739–752
  41. Gunsilius E, Duba HC, Petzer AL, et al. Evidence from a leukemia model for maintenance of vascular endothelium by bone marrow-derived endothelial cells. Lancet. 2000;355:1688–1691
  42. Oppliger Leibungudt E, Horn MP, et al. Hematopoietic and endothelial progenitor cell trafficking in patients with myeloproliferative diseases. Haematologica. 2006;91:1465–1472
  43. Zhang H, Vakil V, Braunstein M, et al. Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005;105:3286–3294
  44. Pompilio G, Capogrossi MC, Pesce M, et al. Endothelial progenitor cells and cardiovascular homeostasis: clinical implications. Int J Cardiol. 2009;131:156–167
  45. Vasa M, Fichtlscherer S, Aicher A, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery diseases. Circ Res. 2001;89:E1–E7
  46. Schmidt-Lucke C, Rossig L, Fichtlscherer S, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events. Proof of concept for the clinical importance of cardiovascular repair. Circulation. 2005;111:2981–2987
  47. Werner N, Kosiol S, Schiegl T, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med. 2005;353:999–1007
  48. Kunz GA, Liang G, Kukuloski F, et al. Circulating endothelail progenitor cells predict coronary artery disease severity. Am Heart J. 2006;152:190–195
  49. Massa M, Rosti V, Ferrario M, et al. Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood. 2005;105:199–206
  50. Guven H, Shepherd RM, Bach RG, Capoccia BJ, Link DC. The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. J Am Coll Cardiol. 2006;48:1579–1587
  51. Shintani S, Murohara T, Ikeda H, et al. Mobilization of endothelial progenitor cells in patients wth acute myocardial infarction. Circulation. 2001;103:2776–2779
  52. Leone M, Rutella S, Bonanno G, et al. Mobilization of bone marrow derived stem cells after myocardial infarction and left ventricular function. Eur Heart J. 2005;26:1196–1204
  53. Wojakowski W, Tendera M, Zebzda A, et al. Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients wirth acute myocardial infarction. Eur Heart J. 2006;27:283–289
  54. Massa M, Campanelli R, Bonetti E, Ferrario M, Marinoni B, Rosti V. Rapid and large increase of the frequency of circulating endothelail colony forming cells (ECFCs) generating late outgrowth endothelial cells in patients with acute myocardial infarction. Exp Hematol. 2009;37:8–9
  55. Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone marrow derived angioblasts prevents cardiomyocytes apoptosis, reduces remodeling, and improves cardiac function. Nat Med. 2001;7:430–436
  56. Kawamoto A, Gwon HC, Iwaguro H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation. 2001;103:634–637
  57. Yoshioka T, Ageyama N, Shibata H, et al. Repair of infarcted myocardium mediated by transplanted bone marrow derived CD34+ stem cells in a nonhuman primate model. Stem cells. 2005;23:355–364
  58. Kawamoto A, Tkebuchana T, Yamaguchi J, et al. Intramyocardial translantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial hischemia. Circulation. 2004;107:461–468
  59. Krenning G, van Luyn MJA, Harmsen MC. Endothelial progenitor cell-based neovascularization: implications for therapy. Trends Vasc Med. 2009;15:180–189
  60. Sekiguchi H, Masaaki II, Losordo WD. The relative potency and safety of endothelial progenitor cells and unselected mononuclear cells for recovery from myocardial infarction and ischemia. J Cell Physiol. 2009;219:235–242

PII: S0959-8049(09)00923-X

doi: 10.1016/j.ejca.2009.12.011

European Journal of Cancer
Volume 46, Issue 4 , Pages 697-702 , March 2010