European Journal of Cancer
Volume 46, Issue 5 , Pages 880-884 , March 2010

Understanding the problem of inadequately staging early ovarian cancer

  • P.J. Timmers

      Affiliations

    • Department of Gynecology and Obstetrics, Maasstad Hospital, Rotterdam, The Netherlands
    • Department of Gynecology, Leiden University Medical Center, The Netherlands
    • Corresponding Author InformationCorresponding author: Address: Department of Gynecology and Obstetrics, Maasstad Hospital, Groene Hilledijk 315, 3075 EA Rotterdam, The Netherlands. Tel.: +31 10 2913381; fax: +31 10 2913011.
    • On behalf of the Gynecological Cancer Group (GCG) of the European Organisation for Research and Treatment of Cancer (EORTC).
  • ,
  • A.H. Zwinderman

      Affiliations

    • Department of Biostatistics, Academic Medical Center, Amsterdam, The Netherlands
    • On behalf of the Gynecological Cancer Group (GCG) of the European Organisation for Research and Treatment of Cancer (EORTC).
  • ,
  • C. Coens

      Affiliations

    • Data Center, European Organisation for Research and Treatment of Cancer, Brussels, Belgium
    • On behalf of the Gynecological Cancer Group (GCG) of the European Organisation for Research and Treatment of Cancer (EORTC).
  • ,
  • I. Vergote

      Affiliations

    • Department of Gynecology and Obstetrics, University Hospitals Leuven, Belgium
    • On behalf of the Gynecological Cancer Group (GCG) of the European Organisation for Research and Treatment of Cancer (EORTC).
  • ,
  • J.B. Trimbos

      Affiliations

    • Department of Gynecology, Leiden University Medical Center, The Netherlands
    • On behalf of the Gynecological Cancer Group (GCG) of the European Organisation for Research and Treatment of Cancer (EORTC).

Received 10 September 2009 ,Revised 29 November 2009 ,Accepted 3 December 2009.

References 

  1. Piver M, Barlow J, Shashikant B. Incidence of subclinical metastasis in stage I and II ovarian carcinoma. Obstet Gynecol. 1978;50:100–104
  2. Young R, Decker D, Wharton J, et al. Staging laparotomy in early ovarian cancer patients. JAMA. 1983;250:3072–3076
  3. Soper J, Johnson P, Johnson V, Berchuk A, Clarke D. Comprehensive restaging laparotomy in women with apparent early ovarian carcinoma. Obstet Gynecol. 1992;80:950–953
  4. Zanetta G, Rota S, Chiari S, et al. The accuracy of staging: an important prognostic determinator in stage I ovarian carcinoma. A multivariate analysis. Ann Oncol. 1998;9:1097–1101
  5. Trimbos JB, Vergote I, Bolis G, et al. Impact of adjuvant chemotherapy and surgical staging in early-stage ovarian carcinoma. European Organisation for Research and Treatment of Cancer. Adjuvant chemotherapy in ovarian neoplasm trial. J Natl Cancer Inst. 2003;95:113–124
  6. Mutch D. Surgical management of ovarian cancer. Semin Oncol. 2002;29:3–8
  7. Nickles Fader A, Rose P. Role of surgery in ovarian carcinoma. J Clin Oncol. 2007;25:2873–2883
  8. Verleye L, Ottevanger PB, van der Graaf W, Reed NS, Vergote I on behalf of the Gynaecological Cancer Group (GCG) of the European Organisation for Research (EORTC) Treatment of Cancer. EORTC-GCG process quality indicators for ovarian cancer surgery. Eur J Cancer. 2009;45:517–526
  9. McGowan L, Lesher L, Norris H, Barnett M. Misstaging of ovarian cancer. Obstet Gynecol. 1985;65:568–572
  10. Le T, Adolph A, Krepart G, Lotocki R, Heywood M. The benefits of comprehensive surgical staging in the management of early-stage epithelial ovarian carcinoma. Gynecol Oncol. 2002;85:351–355
  11. Trimbos JB, Schueler JA, Lent M van, Hermans J, Fleuren GJ. Reasons for incomplete surgical staging in early ovarian carcinoma. Obstet Gynecol. 1985;65:568–572
  12. Engelen M, Kos H, Willemse P, et al. Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma. Cancer. 2005;106:589–598
  13. Tingulstad S, Skjeldestad FE, Hagen B. The effect of centralization of primary surgery on survival in ovarian cancer patients. Obstet Gynecol. 2003;102(3):499–505
  14. Andersen E, Knudsen A, Svarrer T, et al. The results of treatment of epithelial ovarian cancer after centralisation of primary surgery. Results from North Jutland, Denmark. Gynecol Oncol. 2005;99:552–556
  15. Andersen ES, Knudsen A, Rix P, Johansen B. Risk of malignancy index in the preoperative evaluation of patients with adnexal masses. Gynecol Oncol. 2003;90:109–112
  16. Ulusoy S, Akbayir O, Numanoglu C, et al. The risk of malignancy index in discrimination of adnexal masses. Int J Gynaecol Obstet. 2007;96:186–191
  17. Enakpene CA, Omigbodun AO, Goecke TW, Odukogbe AT, Beckmann MW. Preoperative evaluation and triage of women with suspicious adnexal masses using risk of malignancy index. J Obstet Gynaecol Res. 2009;35:131–138
  18. Van Calster B, Timmerman D, Bourne T, et al. Discrimination between benign and malignant adnexal masses by specialist ultrasound examination versus serum CA 125. J Natl Cancer Inst. 2007;99(22):1706–1714
  19. Ioka A, Tsukuma H, Ajiki W, Oshima A. Influence of hospital procedure volume on ovarian cancer survival in Japan, a country with low incidence of ovarian cancer. Cancer Sci. 2004;95:233–237
  20. Vernooij F, Heintz AP, Coebergh JW, et al. Specialized and high-volume care leads to better outcomes in ovarian cancer treatment in the Netherlands. Gynecol Oncol. 2009;112:455–461

PII: S0959-8049(09)00924-1

doi: 10.1016/j.ejca.2009.12.012

European Journal of Cancer
Volume 46, Issue 5 , Pages 880-884 , March 2010