European Journal of Cancer
Volume 46, Issue 4 , Pages 811-817 , March 2010

Anthocyanin-rich red grape extract impedes adenoma development in the ApcMin mouse: Pharmacodynamic changes and anthocyanin levels in the murine biophase

  • Hong Cai

      Affiliations

    • Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
  • ,
  • Timothy H. Marczylo

      Affiliations

    • Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
  • ,
  • Nicole Teller

      Affiliations

    • Institute of Analytical Chemistry and Food Chemistry, University of Vienna, Austria
    • Institute of Applied Biosciences, Section of Food Toxicology, University of Karlsruhe, Germany
  • ,
  • Karen Brown

      Affiliations

    • Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
  • ,
  • William P. Steward

      Affiliations

    • Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
  • ,
  • Doris Marko

      Affiliations

    • Institute of Analytical Chemistry and Food Chemistry, University of Vienna, Austria
    • Institute of Applied Biosciences, Section of Food Toxicology, University of Karlsruhe, Germany
  • ,
  • Andreas J. Gescher

      Affiliations

    • Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    • Corresponding Author InformationCorresponding author: Address: Department of Cancer Studies and Molecular Medicine, RKCSB, University of Leicester, Leicester LE2 7LX, UK. Tel.: +44 1162231856; fax: +44 1162231855.

Received 21 July 2009 ,Revised 7 December 2009 ,Accepted 9 December 2009.

References 

  1. Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol. 2007;3:360–366
  2. Harris GK, Gupta A, Nines RG, et al. Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2′-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer. 2001;40:125–133
  3. Hagiwara A, Miyashita K, Nakanishi T, et al. Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett. 2001;171:17–25
  4. Hagiwara A, Yoshino H, Ichihara T, et al. Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J Toxicol Sci. 2001;27:57–68
  5. Chen T, Hwang HJ, Rose ME, et al. Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. Cancer Res. 2006;66:2853–2859
  6. Misikangas M, Pajari AM, Paivarinta E, et al. Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa. J Nutr. 2007;137:2285–2290
  7. Cooke DN, Schwarz M, Boocock DJ, et al. Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis - relationship with tissue anthocyanin levels. Int J Cancer. 2006;119:2213–2220
  8. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science. 1992;256:668–670
  9. Thomasset S, Berry DP, Cai H, et al. Pilot study of oral anthocyanins for colorectal cancer chemoprevention. Cancer Prev Res. 2009;2:625–633
  10. Cooke D, Steward WP, Gescher AJ, Marczylo TM. Anthocyans from fruits and vegetables – does bright colour signal cancer chemopreventive activity?. Eur J Cancer. 2005;41:1931–1940
  11. Perkins S, Verschoyle RD, Hill K, et al. Chemopreventive efficacy and pharmacokinetics of curcumin in the Min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev. 2002;11:535–540
  12. Workman P, Twentyman P, Balkwill F, et al. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) guidelines for the welfare of animals in experimental neoplasia (second edition). Brit J Cancer. 1998;77:1–10
  13. Rao CV, Swamy MV, Patlolla JMR, Kopelovich L. Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APC min/+ mice. Cancer Res. 2008;68:7670–7675
  14. McGhie TK, Walton MC. The bioavailability and absorption of anthocyanins: towards a better understanding. Mol Nutr Food Res. 2007;51:702–713
  15. De Giovanni C, Landuzzi L, Nicoletti G, et al. Apc10.1: an ApcMin/+ intestinal cell line with retention of heterozygosity. Int J Cancer. 2004;109:200–206
  16. Bridle P, Timberlake CF. Anthocyanins as natural food colours – selected aspects. Food Chem. 1997;58:103–109
  17. Teller N, Thiele W, Marczylo TH, et al. Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes. J Agri Food Chem. 2009;57:3094–3101
  18. Teller N, Thiele W, Boettler U, et al. Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Mol Nutr Food Res; in press.
  19. Fridrich D, Teller N, Esselen M, et al. Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of EGFR and ErbB2 receptor phosphorylation. Mol Nutr Food Res. 2008;52:815–822
  20. Kang NJ, Lee KW, Kwon JY, et al. Delphinidin attenuates neoplastic transformation in JB6 CI41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. Cancer Prev Res. 2008;1:522–531

PII: S0959-8049(09)00929-0

doi: 10.1016/j.ejca.2009.12.017

European Journal of Cancer
Volume 46, Issue 4 , Pages 811-817 , March 2010