« Previous
Next »
European Journal of Cancer
Volume 46, Issue 8
, Pages 1430-1437
, May 2010
Loss of expression of TIMP3 in clear cell renal cell carcinoma
References
- The Heidelberg classification of renal cell tumours. J Pathol. 1997;183:131–133
- Identification of the von Hippel–Lindau disease tumor suppressor gene. Science. 1993;260:1317–1320
- Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature. 1988;332:268–269
- VHL protein alterations in sporadic renal cell carcinoma. Clin Oncol. 2007;19:784–789
- Genetic and epigenetic alterations in the von hippel–lindau gene: the influence on renal cancer prognosis. Clin Cancer Res. 2008;14:782–787
- . Role of VHL gene mutation in human cancer. J Clin Oncol. 2004;22:4991–5004
- Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma. Oncol Rep. 2005;13:859–864
- Hypoxia Inducible Factor-alpha binding and ubiquitylation by the von Hippel–Lindau tumor suppressor protein. J Biol Chem. 2000;275:25733–25741
- Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel–Lindau gene status. BJU Int. 2006;98:756–762
- Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115–124
- Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun. 1992;187:1579–1586
- . Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA. 1993;90:7533–7537
- A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nat Med. 2003;9:407–415
- . Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics. 1994;19:86–90
- . DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma. Biomed Pharmacother. 2005;59:S363–S365
- . Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer. Cancer Lett. 2007;247:91–97
- Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas. Pancreas. 2005;30:e40–e45
- Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) are found frequently in human colorectal tumours displaying either microsatellite stability (MSS) or instability (MSI). Cancer Lett. 2005;223:137–142
- Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells. J Pathol. 2005;207:156–163
- Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res. 2002;30:e57
- . Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes. Cell Signal. 2007;19:1643–1651
- High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. Br J Cancer. 2007;96:1888–1895
- Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 1999;59:798–802
- . Cytogenetic alterations in renal tumors: a study of 38 Southeast Asian patients. Cancer Genet Cytogenet. 2007;175:1–7
- Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression. Oncogene. 2003;22:8053–8062
- CpG methylation at promoter site-140 inactivates TGFbeta2 receptor gene in prostate cancer. Cancer. 2005;104:44–52
- A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res. 1995;55:5545–5547
- Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science. 1995;268:1336–1338
- . Loss of expression of transforming growth factor-beta receptor as a prognostic factor in patients with renal cell carcinoma. Urology. 2003;61:1072–1077
- Lower expression levels of the transforming growth factor beta receptor type II protein are associated with a less aggressive tumor phenotype and improved survival among patients with clear cell renal cell carcinoma. Hum Pathol. 2007;38:453–461
- Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. Carcinogenesis. 1996;17:1805–1811
- . Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. Br J Cancer. 1999;79:1347–1355
PII: S0959-8049(10)00028-6
doi: 10.1016/j.ejca.2010.01.009
« Previous
Next »
European Journal of Cancer
Volume 46, Issue 8
, Pages 1430-1437
, May 2010
