European Journal of Cancer
Volume 46, Issue 5 , Pages 859-862, March 2010

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

  • Iman El-Hariry

      Affiliations

    • Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom
    • ,
  • Thomas Powles

      Affiliations

    • Department of Medical Oncology, St Bartholomew’s Hospital, London EC1A7BE, United Kingdom
    • ,
  • Mike R. Lau

      Affiliations

    • Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom
    • ,
  • Cora N. Sternberg

      Affiliations

    • Department of Medical Oncology, San Camillo Forlanini Hospital, Rome 00152, Italy
    • ,
  • Alain Ravaud

      Affiliations

    • Department of Medical Oncology, CHU Bordeaux, 33075 Bordeaux, France
    • ,
  • Hans von der Maase

      Affiliations

    • Department of Oncology, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    • ,
  • Niko Zantl

      Affiliations

    • Department of Urology and Paediatric Urology, Klinikum Konstanz, 78464 Konstanz, Germany
    • ,
  • Peter Harper

      Affiliations

    • Department of Medical Oncology, Guy’s and St Thomas’ Hospitals, London SE1 9RT, United Kingdom
    • ,
  • Frédéric Rolland

      Affiliations

    • Medical Oncology, Centre René Gauducheau, 44800 Saint Herblain, France
    • ,
  • Bruno Audhuy

      Affiliations

    • Department of Oncology-Hematology, Hôpital Pasteur, 68024 Colmar, France
    • ,
  • Friederike Barthel

      Affiliations

    • Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom
    • ,
  • Jean-Pascal Machiels

      Affiliations

    • Department of Medical Oncology, Université catholique de Louvain, 1200 Brussels, Belgium
    • ,
  • Pina Patel

      Affiliations

    • Academic Unit of Clinical Oncology, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    • ,
  • Ernst-Dietrick Kreuser

      Affiliations

    • Klinik für Internistische Onkologie und Hämatologie, Krankenhaus Barmherzige Brüder, 93049 Regensburg, Germany
    • ,
  • Robert E. Hawkins

      Affiliations

    • Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom
    • Corresponding Author InformationCorresponding author: Tel.: +44 161 446 3208; fax: +44 161 446 3269.

Received 23 August 2009; received in revised form 11 January 2010; accepted 14 January 2010. published online 18 February 2010.

Abstract 

Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

Keywords: Renal cell carcinoma, Epidermal growth factor receptor, Fluorescent in situ hybridisation

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0959-8049(10)00030-4

doi:10.1016/j.ejca.2010.01.011

European Journal of Cancer
Volume 46, Issue 5 , Pages 859-862, March 2010

Article Tools

* Image Usage & Resolution