European Journal of Cancer
Volume 46, Issue 9 , Pages 1640-1649 , June 2010

The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma

  • Feng Zhi

      Affiliations

    • Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • These authors contributed equally to this work.
    • ,
  • Xi Chen

      Affiliations

    • Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    • These authors contributed equally to this work.
    • ,
  • Suinuan Wang

      Affiliations

    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Xiwei Xia

      Affiliations

    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Yimin Shi

      Affiliations

    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Wei Guan

      Affiliations

    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Naiyuan Shao

      Affiliations

    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Hongtao Qu

      Affiliations

    • Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Changchun Yang

      Affiliations

    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Yi Zhang

      Affiliations

    • Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Qiang Wang

      Affiliations

    • Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Rong Wang

      Affiliations

    • Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • ,
  • Ke Zen

      Affiliations

    • Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    • ,
  • Chen-Yu Zhang

      Affiliations

    • Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    • Corresponding Author InformationCorresponding authors: Address: Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China. Tel./fax: +86 519 86180899 (Y. Yang).
    • ,
  • Junfeng Zhang

      Affiliations

    • Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    • Corresponding Author InformationCorresponding authors: Address: Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China. Tel./fax: +86 519 86180899 (Y. Yang).
    • ,
  • Yilin Yang

      Affiliations

    • Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Department of Neurosurgery, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    • Corresponding Author InformationCorresponding authors: Address: Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China. Tel./fax: +86 519 86180899 (Y. Yang).

Received 21 August 2009 ,Revised 28 January 2010 ,Accepted 5 February 2010.

References 

  1. Walker DG, Kaye AH. Diagnosis and management of astrocytomas, oligodendrogliomas and mixed gliomas: a review. Austral Radiol. 2001;45:472–482
  2. Mathieu D, Fortin D. The role of chemotherapy in the treatment of malignant astrocytomas. Can J Neurol Sci. 2006;33:127–140
  3. Okamoto Y, Di Patre PL, Burkhard C, et al. Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. Acta Neuropathol. 2004;108:49–56
  4. Chosdol K, Misra A, Puri S, et al. Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene ‘FAT’ in human astrocytic tumors. BMC Cancer. 2009;9:5
  5. Oji Y, Suzuki T, Nakano Y, et al. Overexpression of the Wilms’ tumor gene W T1 in primary astrocytic tumors. Cancer Sci. 2004;95:822–827
  6. Shiraishi S, Tada K, Nakamura H, et al. Influence of p53 mutations on prognosis of patients with glioblastoma. Cancer. 2002;95:249–257
  7. Esquela-Kerscher A, Slack FJ. Oncomirs – microRNAs with a role in cancer. Nat Rev Cancer. 2006;6:259–269
  8. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6:857–866
  9. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–297
  10. Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA. 2006;103:2257–2261
  11. Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435:834–838
  12. Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005;65:7065–7070
  13. Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006;9:189–198
  14. Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. New Engl J Med. 2005;353:1793–1801
  15. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;3:RESEARCH0034.
  16. Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005;33:e179
  17. Tang F, Hajkova P, Barton SC, Lao K, Surani MA. MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res. 2006;34:e9
  18. Hebert SS, Horre K, Nicolai L, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA. 2008;105:6415–6420
  19. Ben-Ami O, Pencovich N, Lotem J, Levanon D, Groner Y. A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis. Proc Natl Acad Sci USA. 2009;106:238–243
  20. Peltier HJ, Latham GJ. Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 2008;14:844–852
  21. Conti A, Aguennouz M, La Torre D, et al. MiR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumors. J Neurooncol. 2009;93:325–332
  22. Silber J, Lim DA, Petritsch C, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008;6:14
  23. Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 2004;101:2999–3004
  24. Sempere LF, Freemantle S, Pitha-Rowe I, et al. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004;5:R13
  25. Beuvink I, Kolb FA, Budach W, et al. A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acids Res. 2007;35:e52
  26. Liang Y, Ridzon D, Wong L, Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 2007;8:166
  27. Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 2007;133:647–658
  28. Chen Y, Liu W, Chao T, et al. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett. 2008;272:197–205
  29. Shi L, Cheng Z, Zhang J, et al. hsa-mir-181a and hsa-mir-181b Function as tumor suppressors in human glioma cells. Brain Res. 2008;1236:185–193
  30. Diaz R, Silva J, Garcia JM, et al. Deregulated expression of miR-106a predicts survival in human colon cancer patients. Genes Chromosomes Cancer. 2008;47:794–802

PII: S0959-8049(10)00106-1

doi: 10.1016/j.ejca.2010.02.003

European Journal of Cancer
Volume 46, Issue 9 , Pages 1640-1649 , June 2010

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