« Previous
Next »
European Journal of Cancer
Volume 46, Issue 13
, Pages 2369-2380
, September 2010
Metformin: Taking away the candy for cancer?
References
- . On the origin of cancer cells. Science. 1956;123:309–314
- . Puzzles, promises and a cure for ageing. Nature. 2008;454:1065–1071
- . AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 2007;100:328–341
- . Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414–1431
- . Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clin Sci (Lond). 2009;118:315–332
- Cancer and diabetes. A follow-up study of two population-based cohorts of diabetic patients. J Intern Med. 1997;241:471–475
- Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol. 2002;20:42–51
- Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis. JAMA. 2008;300:2754–2764
- Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol. 2009;27:3297–3302
- . Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008;8:915–928
- . Insulin resistance and promotion of aberrant crypt foci in the colons of rats on a high-fat diet. Nutr Cancer. 1997;29:69–76
- . Insulin promotion of colon tumors in rats. Cancer Epidemiol Biomarkers Prev. 1996;5:1013–1015
- . Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care. 2006;29:254–258
- Survival analyses from the Women’s Intervention Nutrition Study (WINS) evaluating dietary fat reduction and breast cancer outcome. JCO. 2008;26:522
- The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem. 2008;114:23–37
- . Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells. Cancer Res. 1987;47:6500–6504
- . Insulin receptors in breast cancer: biological and clinical role. J Endocrinol Invest. 1996;19:324–333
- . Insulin and its receptor: structure, function and evolution. Bioessays. 2004;26:1351–1362
- . Insulin-like growth factor-I and cancer risk. Growth Horm IGF Res. 2004;14:261–269
- . Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. J Clin Endocrinol Metab. 2000;85:4712–4720
- . Effects of combined recombinant insulin-like growth factor (IGF)-I and IGF binding protein-3 in type 2 diabetic patients on glycemic control and distribution of IGF-I and IGF-II among serum binding protein complexes. J Clin Endocrinol Metab. 2007;92:2652–2658
- . Insulin-dependent regulation of insulin-like growth factor-binding protein-1. J Clin Endocrinol Metab. 1990;71:1632–1636
- . Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res. 2002;62:1030–1035
- . Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92:1472–1489
- . Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab. 1988;67:460–464
- Pathophysiology of sex hormone binding globulin (SHBG): relation to insulin. J Steroid Biochem Mol Biol. 1991;40:841–849
- . The androgenic profile of women with non-insulin-dependent diabetes mellitus. J Reprod Med. 2004;49:746–752
- . Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men. Eur J Endocrinol. 2010;162:747–754
- . Inflammation and insulin resistance. J Clin Invest. 2006;116:1793–1801
- . Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes. 2002;51:1131–1137
- . Adipocytokines and cancer. Physiol Res. 2006;55:233–244
- . Cancer-related inflammation. Nature. 2008;454:436–444
- The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005;310:1642–1646
- Mammalian AMP-activated protein kinase subfamily. J Biol Chem. 1996;271:611–614
- The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004;6:91–99
- . Defining the role of mTOR in cancer. Cancer Cell. 2007;12:9–22
- Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell cycle. 2009;8:909–915
- The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene. 2008;27:3576–3586
- In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecol Oncol. 2008;110:246–250
- . Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 2006;66:10269–10273
- Insulin-lowering effects of metformin in women with early breast cancer. Clin Breast Cancer. 2008;8:501–505
- . AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. Mol Endocrinol. 2010;24:1218–1229
- . Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res. 2010;16:2505–2511
- . TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115:577–590
- . PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs. 2005;16:797–803
- Zakikhani M, Blouin MJ, Piura E, Pollak MN. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat 2010 [Epub ahead of print].
- . The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle. 2009;8:88–96
- . The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy. Ann Oncol. 2009;20:592–595
- Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells. Cell Cycle. 2008;7:1769–1775
- The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients. Diabetes Res Clin Pract. 2008;81:56–60
- Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes. Eur J Endocrinol. 2008;158:631–641
- . Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model. Breast Cancer Res Treat. 2009;113:101–111
- . Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?. Breast Cancer Res Treat. 2009;114:387–389
- A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009;15:1082–1087
- . AMPK and p53 help cells through lean times. Cell Metab. 2005;1:287–288
- Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res. 2010;70:2465–2475
- Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res. 2007;67:6745–6752
- . Genome-wide inhibitory impact of the AMPK activator metformin on M-phase cell cycle genes in human breast cancer cells. Cell Cycle. 2009;8:1633–1636
- Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340:c2181
- . Metformin, B(12), and enhanced breast cancer response to chemotherapy. J Clin Oncol. 2010;28:e19
- . Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocr Relat Cancer. 2008;15:833–839
- Metformin in chemically-induced mammary carcinogenesis in rats. Neoplasma. 2009;56:269–274
- Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol. 2005;40:685–693
- . Metformin and reduced risk of cancer in diabetic patients. BMJ. 2005;330:1304–1305
- Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care. 2010;33:322–326
- New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 2009;32:1620–1625
- . Diabetes therapy and cancer risk: causal effects and other plausible explanations. Diabetologia. 2010;53:802–808
- Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007;117:1422–1431
- . Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002;136:829–836
- Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene. J Clin Endocrinol Metab. 2008;93:792–800
- . LKB1; linking cell structure and tumor suppression. Oncogene. 2008;27:6908–6919
- Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006;3:403–416
- Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes. Diabetes Care. 2003;26:2069–2074
- Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects. Diabetes. 2003;52:283–290
- Enhancement of insulin-stimulated myocardial glucose uptake in patients with Type 2 diabetes treated with rosiglitazone. Diabet Med. 2004;21:1280–1287
- High and typical 18F-FDG bowel uptake in patients treated with metformin. Eur J Nucl Med Mol Imaging. 2008;35:95–99
- van Dijk TH, Laskewitz AJ, Boer TS, et al. Computational analysis of carbohydrate metabolism. 2010;9:177–94.
- . Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia. 2006;49:2819–2823
- . Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer. 2007;121:856–862
- . Diabetes mellitus and breast cancer. Lancet Oncol. 2005;6:103–111
- . Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst. 2005;97:1679–1687
- . Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia. 2007;50:1365–1374
- . The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol. 2006;4:369–380
- . Type 2 diabetes mellitus and risk of non-Hodgkin lymphoma: a systematic review and meta-analysis. Am J Epidemiol. 2008;168:471–480
- . Diabetes and risk of Non-Hodgkin’s lymphoma: a meta-analysis of observational studies. Diabetes Care. 2008;31:2391–2397
- . Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995;273:1605–1609
- . Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer. 2005;92:2076–2083
- . Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia. 2004;47:1071–1078
- . A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:2056–2062
- Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology. Ann Oncol. 2010;21:187–189
- Metformin diet, breast cancer: an avenue for chemoprevention. Cell Cycle. 2009;8:2661
- . Is it time to test metformin in breast cancer clinical trials?. Cancer Epidemiol Biomarkers Prev. 2009;18:701–705
PII: S0959-8049(10)00487-9
doi: 10.1016/j.ejca.2010.06.012
© 2010 Elsevier Ltd. All rights reserved.
« Previous
Next »
European Journal of Cancer
Volume 46, Issue 13
, Pages 2369-2380
, September 2010
