European Journal of Cancer
Volume 46, Issue 16 , Pages 2870-2878, November 2010

Dose-escalation models for combination phase I trials in oncology

  • Paul Hamberg

      Affiliations

    • Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    • Present address: Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
    • Corresponding Author InformationCorresponding author: Address: Erasmus University Medical Center, Daniel den Hoed Cancer Center, Department of Medical Oncology, P.O. Box 5201, 3008 AE Rotterdam, The Netherlands. Tel.: +31 10 7041505; fax: +31 10 7041003.
    • ,
  • Mark J. Ratain

      Affiliations

    • Department of Medicine, University of Chicago, Chicago, United States
    • ,
  • Emmanuel Lesaffre

      Affiliations

    • Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    • L-Biostat, Catholic University of Leuven, U.Z. St. Rafael, Leuven, Belgium
    • ,
  • Jaap Verweij

      Affiliations

    • Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Received 28 June 2010; accepted 2 July 2010. published online 06 August 2010.

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PII: S0959-8049(10)00659-3

doi:10.1016/j.ejca.2010.07.002

European Journal of Cancer
Volume 46, Issue 16 , Pages 2870-2878, November 2010

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