European Journal of Cancer
Volume 46, Issue 16 , Pages 2926-2935 , November 2010

The tumour-targeting human L19-IL2 immunocytokine: Preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma

  • Manfred Johannsen

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • These authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author: Tel.: +49 30 450615163; fax: +49 30 450515915.
    • ,
  • Gianluca Spitaleri

      Affiliations

    • Clinical Pharmacology and New Drugs Development Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    • These authors contributed equally to this work.
    • ,
  • Giuseppe Curigliano

      Affiliations

    • Clinical Pharmacology and New Drugs Development Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    • ,
  • Jan Roigas

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Steffen Weikert

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Carsten Kempkensteffen

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Andreas Roemer

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Christian Kloeters

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Patrik Rogalla

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Gabriele Pecher

      Affiliations

    • Department of Oncology and Hematology, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    • ,
  • Kurt Miller

      Affiliations

    • Department of Urology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
    • ,
  • Alexander Berndt

      Affiliations

    • Institute of Pathology, University Hospital Jena, Bachstraße 18, 07743 Jena, Germany
    • ,
  • Hartwig Kosmehl

      Affiliations

    • Institute of Pathology, HELIOS-Klinikum, Nordhäuser Str. 74, 99089 Erfurt, Germany
    • ,
  • Eveline Trachsel

      Affiliations

    • Philochem AG, Industriestrasse 30, 8112 Otelfingen, Switzerland
    • ,
  • Manuela Kaspar

      Affiliations

    • Philochem AG, Industriestrasse 30, 8112 Otelfingen, Switzerland
    • ,
  • Valeria Lovato

      Affiliations

    • Philochem AG, Industriestrasse 30, 8112 Otelfingen, Switzerland
    • ,
  • Reinerio González-Iglesias

      Affiliations

    • Philogen SpA, La Lizza 7,53100 Siena, Italy
    • ,
  • Leonardo Giovannoni

      Affiliations

    • Philogen SpA, La Lizza 7,53100 Siena, Italy
    • ,
  • Hans D. Menssen

      Affiliations

    • Bayer Schering Pharma AG, Müllerstrasse, 13353 Berlin, Germany
    • ,
  • Dario Neri

      Affiliations

    • Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland
    • Corresponding Author InformationCorresponding author: Tel.: +41 44 633 74 01; fax: +41 44 633 13 58.
    • ,
  • Filippo de Braud

      Affiliations

    • Clinical Pharmacology and New Drugs Development Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy

Received 26 May 2010 ,Revised 19 July 2010 ,Accepted 22 July 2010.

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☆ ClinicalTrials.gov Identifier: NCT01058538.

PII: S0959-8049(10)00728-8

doi: 10.1016/j.ejca.2010.07.033

European Journal of Cancer
Volume 46, Issue 16 , Pages 2926-2935 , November 2010

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