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European Journal of Cancer
Volume 46, Issue 18
, Pages 3219-3232
, December 2010
Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy
References
- Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. New Engl J Med. 2002;347:1227–1232
- Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. New Engl J Med. 2002;347:1233–1241
- Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst. 2000;92:1143–1150
- Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial. Cancer. 2003;98:697–702
- Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst Monographs. 1992;(11):19–25
- Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366:2087–2106
- . Advances in breast conservation therapy. J Clin Oncol. 2005;23:1685–1697
- Standard for breast conservation therapy in the management of invasive breast carcinoma. CA: Cancer J Clin. 2002;52:277–300
- . Comparison of psychological aspects and patient satisfaction following breast conserving surgery, simple mastectomy and breast reconstruction. Eur J Cancer. 2000;36:1938–1943
- . Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. Am J Surg. 2002;184:383–393
- Breast cancer. Clinical practice guidelines in oncology. J Natl Comprehens Cancer Network. 2009;7:122–192
- Consensus conference on breast conservation. J Am Coll Surg. 2006;203:198–207
- . Margins in breast-conserving therapy: have we lost sight of the big picture?. Expert Rev Anticancer Therapy. 2008;8:1193–1196
- The surgical margin status after breast-conserving surgery: discussion of an open issue. Breast Cancer Res Treat. 2009;113:397–402
- . Prognostic factors for local control after breast conservation: does margin status still matter?. J Clin Oncol. 2009;27:4929–4930
- Role of resection margins in patients treated with breast conservation surgery. Cancer. 2008;112:1923–1931
- . Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey. Ann Surg. 2005;241:629–639
- General rules for clinical and pathological recording of breast cancer. Breast Cancer. 2005;12(Suppl.):27
- . Factors associated with ipsilateral breast failure and distant metastases in patients with invasive breast carcinoma treated with breast-conserving therapy: a clinicopathologic study of 607 neoplasms from 583 patients. Am J Clin Pathol. 2003;120:500–527
- Long-term follow-up of a prospective policy of margin-directed radiation dose escalation in breast-conserving therapy. Cancer. 2003;97:30–39
- Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol. 2000;18:1668–1675
- . Systematic reviews of evaluations of prognostic variables. In: Egger M, Smith GD, Altman DG editor. Systematic reviews in health care: meta-analysis in context. 2nd ed.. London: BMJ Publishing Group; 2001;p. 228–247
- In: Guyatt G, Rennie D editor. Users’ guide to the medical literature. A manual for evidence-based clinical practice. Chicago: AMA Press; 2002;p. 141–154
- Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy. Int J Radiat Oncol Biol Phys. 1999;44:1005–1015
- . Negative margin status improves local control in conservatively managed breast cancer patients. Cancer Journal from Scientific American. 1999;6:28–33
- Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys. 1999;43:25–38
- Results of breast-conserving therapy for early stage breast cancer: Kyoto university experiences. Am J Clin Oncol Cancer Clin Trials. 2000;23:499–505
- Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials. J Clin Oncol. 2001;19:1688–1697
- Breast-conserving surgery following radiation therapy of 50 Gy in stages I and II carcinoma of the breast: the experience at one institute in Japan. Oncol Rep. 2002;9:1053–1057
- Predictors of locoregional recurrence among patients with early-stage breast cancer treated with breast-conserving therapy. Ann Surg Oncol. 2002;9:256–265
- Outcome of breast-conserving therapy in the Tokyo Women’s Medical University Breast Cancer Society experience. Breast Cancer. 2003;10:241–248
- . Conservation therapy in T1–T2 breast cancer: past, current issues, and future challenges and opportunities. Cancer J. 2003;9:442–453
- . Predictors of reexcision findings and recurrence after breast conservation. Int J Radiat Oncol Biol Phys. 2003;57:979–985
- Fifteen-year results of breast-conserving surgery and definitive irradiation for Stage I and II breast carcinoma: the University of Pennsylvania experience. Int J Radiat Oncol Biol Phys. 2004;58:233–240
- Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: updated results of a prospective randomized trial. J Clin Oncol. 2005;23:1934–1940
- Treatment outcome of breast-conserving therapy in patients with positive or close resection margins: Japanese multi institute survey for radiation dose effect. Breast Cancer. 2005;12:91–98
- Breast conservation surgery achieving > or =2
mm tumor-free margins results in decreased local–regional recurrence rates. Breast J. 2006;12:28–36 - The effect of timing of radiotherapy after breast-conserving surgery in patients with positive or close resection margins, young age, and node-negative disease, with long term follow-up. Int J Radiat Oncol Biol Phys. 2006;66:687–690
- Breast conserving treatment in Denmark, 1989–1998. A nationwide population-based study of the Danish Breast Cancer Co-operative Group. Acta Oncol. 2008;47:682–690
- Continuing risk of ipsilateral breast relapse after breast-conserving therapy at long-term follow-up. Int J Radiat Oncol Biol Phys. 2008;71:1014–1021
- The role of radiotherapy in treating small early invasive breast cancer. Eur J Surg Oncol. 2008;34:369–376
- . Recursive partitioning identifies patients at high and low risk for ipsilateral tumor recurrence after breast-conserving surgery and radiation. J Clin Oncol. 2002;20:4015–4021
- The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy. Cancer. 1994;74:1746–1751
- Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer. 1996;78:1921–1928
- Improving local control with breast-conserving therapy: a 27-year single-institution experience. Cancer. 2005;104:20–29
- Surgical margin and breast recurrence after breast-conserving therapy. Oncol Rep. 1999;6:135–138
- Factors determining outcome for breast-conserving irradiation with margin-directed dose escalation to the tumor bed. Int J Radiat Oncol Biol Phys. 1998;40:851–858
- The importance of the lumpectomy surgical margin status in long-term results of breast conservation. Cancer. 1995;76:259–267
- . The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys. 1991;21:279–287
- . Outcomes in breast cancer patients relative to margin status after treatment with breast-conserving surgery and radiation therapy: The University of Pennsylvania experience. Int J Radiat Oncol Biol Phys. 1999;43:1029–1035
- The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. New Engl J Med. 1996;334:1356–1361
- Risk factors in breast-conservation therapy. J Clin Oncol. 1994;12:653–660
- Long term results with breast-conserving therapy for patients with early stage breast carcinoma in a community hospital setting. Cancer. 1998;82:127–133
- . Influence of radiation dose on positive surgical margins in women undergoing breast conservation therapy. Int J Radiat Oncol Biol Phys. 2002;53:680–686
- Lumpectomy margins, reexcision, and local recurrence of breast cancer. Am J Surg. 2000;179:81–85
- . The importance of the resection margin in conservative surgery for breast cancer. Eur J Surg Oncol. 1996;22:17–22
- Patients with t1 to t2 breast cancer with one to three positive nodes have higher local and regional recurrence risks compared with node-negative patients after breast-conserving surgery and whole-breast radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:357–364
- Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial. Radiother Oncol. 2009;90:80–85
- Importance of margin status in outcome of breast-conserving surgery for carcinoma. Surgery. 1994;116:605–609
- Clinical outcome of breast conservation therapy for breast cancer in Hong Kong: prognostic impact of ipsilateral breast tumor recurrence and 2005 St. gallen risk categories. Int J Radiat Oncol Biol Phys. 2007;68:667–672
- Age remains the first prognostic factor for loco-regional breast cancer recurrence in young (<40 years) women treated with breast conserving surgery first. Radiother Oncol. 2007;82:272–280
- . The impact of margin status on local recurrence following breast conserving therapy for invasive carcinoma in Manitoba. J Surg Oncol. 2008;98:399–402
- Eight-year results of a prospective non-randomised study on therapy of small breast cancer. The German Breast Cancer Study Group (GBSG). Eur J Cancer. 1998;34:315–323
- Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial. J Clin Oncol. 2009;27:4939–4947
- Ipsilateral breast tumor relapse after breast conserving surgery in women with breast cancer. Breast. 2009;18:238–243
- . Locoregional treatment of primary breast cancer: consensus recommendations from an International Expert Panel. Cancer. 2010;116:1184–1191
- Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1–98. J Clin Oncol. 2007;25:486–492
- A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. New Engl J Med. 2004;350:1081–1092
- Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. New Engl J Med. 2005;353:1673–1684
- 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet. 2007;369:29–36
- . Multicentricity of breast carcinoma demonstrated by routine correlated serial subgross and radiographic examination. Cancer. 1977;40:1726–1734
- . Histologic multifocality of Tis, T1–2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer. 1985;56:979–990
- Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution. Cancer. 2004;101:713–720
- Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement 2009. PLoS Med 6(6), doi:10.1371/journal.pmed1000097.
☆ This work was partly funded by the National Health and Medical Research Council (NHMRC) program grant 402764 to the Screening & Test Evaluation Program.
PII: S0959-8049(10)00753-7
doi: 10.1016/j.ejca.2010.07.043
© 2010 Elsevier Ltd. All rights reserved.
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European Journal of Cancer
Volume 46, Issue 18
, Pages 3219-3232
, December 2010
