European Journal of Cancer
Volume 47, Issue 1 , Pages 121-130 , January 2011

Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1

  • Wenjing Zhang

      Affiliations

    • Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Jide Wang

      Affiliations

    • Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Bing Zou

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Claude Sardet

      Affiliations

    • Institut de Genetique Moleculaire, Universite de Montpellier, Montpellier, France
    • ,
  • Jianming Li

      Affiliations

    • Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
    • ,
  • Colin S.C. Lam

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Lui Ng

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Roberta Pang

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Ivan F.N. Hung

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Victoria P.Y. Tan

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • ,
  • Bo Jiang

      Affiliations

    • Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    • Corresponding Author InformationCorresponding author: Tel.: +86 20 61641541.
    • ,
  • Benjamin C.Y. Wong

      Affiliations

    • Department of Medicine, Center for Cancer Research, University of Hong Kong, Hong Kong
    • Corresponding Author InformationCorresponding author: Address: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. Tel.: +852 2255 4049; fax: +852 2904 9443.

Received 25 June 2010 ,Revised 28 July 2010 ,Accepted 29 July 2010.

References 

  1. Turley EA, Veiseh M, Radisky DC, Bissell MJ. Mechanisms of disease: epithelial–mesenchymal transition – does cellular plasticity fuel neoplastic progression?. Nat Clin Pract Oncol. 2008;5:280–290
  2. Shook D, Keller R. Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development. Mech Dev. 2003;120:1351–1383
  3. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial–mesenchymal transitions in development and disease. Cell. 2009;139:871–890
  4. Bates RC, Mercurio AM. The epithelial–mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther. 2005;4:365–370
  5. Thiery JP. Epithelial–mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2:442–454
  6. Giroldi LA, Bringuier PP, De Weijert M, et al. Role of E boxes in the repression of E-cadherin expression. Biochem Biophys Res Commun. 1997;241:453–458
  7. Ji X, Woodard AS, Rimm DL, Fearon ER. Transcriptional defects underlie loss of E-cadherin expression in breast cancer. Cell Growth Differ. 1997;8:773–778
  8. Batlle E, Sancho E, Franci C, et al. The transcription factor Snail1 is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2000;2:84–89
  9. Liu YN, Lee WW, Wang CY, et al. Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene. 2005;24:8277–8290
  10. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat Rev Cancer. 2007;7:415–428
  11. Yokoyama K, Kamata N, Fujimoto R, et al. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol. 2003;22:891–898
  12. Peña C, García JM, García V, et al. The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL1, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Int J Cancer. 2006;119:2098–2104
  13. Roy HK, Smyrk TC, Koetsier J, Victor TA, Wali RK. The transcriptional repressor SNAIL1 is overexpressed in human colon cancer. Dig Dis Sci. 2005;50:42–46
  14. Cheng CW, Wu PE, Yu JC, et al. Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumour suppressor gene. Oncogene. 2001;20:3814–3823
  15. Jiao W, Miyazaki K, Kitajima Y. Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo. Brit J Cancer. 2002;86:98–101
  16. Zhou BP, Deng J, Xia W, et al. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial–mesenchymal transition. Nat Cell Biol. 2004;6:931–940
  17. Johannessen M, Møller S, Hansen T, Moens U, Van Ghelue M. The multifunctional roles of the four-and-a-half-LIM only protein FHL2. Cell Mol Life Sci. 2006;63:268–284
  18. Li M, Wang J, Ng SS, et al. The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities. Glia. 2008;56:1328–1338
  19. Wang J, Yang Y, Xia HH, et al. Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. Gastroenterology. 2007;132:1066–1076
  20. Yang Y, Hou H, Haller EM, Nicosia SV, Bai W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 2005;24:1021–1032
  21. Gabriel B, Fischer DC, Orlowska-Volk M, et al. Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study. J Soc Gynecol Investig. 2006;13:69–75
  22. Chen D, Xu W, Bales E, et al. SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res. 2003;63:6626–6634
  23. Wei Y, Renard CA, Labalette C, et al. Identification of the LIM protein FHL2 as a coactivator of beta-catenin. J Biol Chem. 2003;278:5188–5194
  24. Kim Y, Kugler MC, Wei Y, et al. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol. 2009;184:309–322
  25. Zhang W, Jiang B, Guo Z, et al. Four and a half LIM protein 2 (FHL2) promotes invasive potential and epithelial–mesenchymal transition in colon cancer. Carcinogenesis. 2010;31:1220–1229
  26. Wang J, Peng Y, Sun YW, et al. All-trans retinoic acid induces XAF1 expression through an interferon regulatory factor-1 element in colon cancer. Gastroenterology. 2006;130:747–758
  27. Wang J, Gu Q, Li M, et al. Identification of XAF1 as a novel cell cycle regulator through modulating G(2)/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer. Carcinogenesis. 2009;30:1507–1516
  28. Wang J, Zhang W, Zhang Y, et al. C-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer. Carcinogenesis. 2009;30:222–229
  29. Stemmer V, de Craene B, Berx G, Behrens J. Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene. 2008;27:5075–5080
  30. Langer EM, Feng Y, Zhaoyuan H, et al. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cel. 2008;14:424–436
  31. Hou Z, Peng H, Ayyanathan K, et al. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol. 2008;28:3198–3207
  32. Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development. 2005;132:3151–3161
  33. Bolós V, Peinado H, Pérez-Moreno MA, et al. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci. 2003;116:499–511
  34. Olmeda D, Montes A, Moreno-Bueno G, et al. Snai1 and Snai2 collaborate on tumour growth and metastasis properties of mouse skin carcinoma cell lines. Oncogene. 2008;27:4690–4701
  35. Kleiber K, Strebhardt K, Martin BT. The biological relevance of FHL2 in tumour cells and its role as a putative cancer target. Anticancer Res. 2007;27:55–61
  36. Moustakas A, Heldin CH. Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 2007;98:1512–1520
  37. Purcell NH, Darwis D, Bueno OF, et al. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Mol Cell Biol. 2004;24:1081–1095

PII: S0959-8049(10)00755-0

doi: 10.1016/j.ejca.2010.07.045

European Journal of Cancer
Volume 47, Issue 1 , Pages 121-130 , January 2011

Article Tools

* Image Usage & Resolution