European Journal of Cancer
Volume 47, Issue 10 , Pages 1468-1475 , July 2011

Heterogeneity in the definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents: A review of the literature

  • Christophe Le Tourneau

      Affiliations

    • Department of Medical Oncology, Institut Curie, Paris, France
    • Corresponding Author InformationCorresponding author: Address: Institut Curie, Department of Medical Oncology, 26, rue d’Ulm, 75248 Paris Cedex 05, France. Tel.: +33 1 4432 4086; fax: +33 1 5310 4006.
    • ,
  • Albiruni R.A. Razak

      Affiliations

    • Department of Medical Oncology, Princess Margaret Hospital, Toronto, Canada
    • ,
  • Hui K. Gan

      Affiliations

    • Austin-Ludwig Cancer Unit, Austin Hospital, Melbourne, Australia
    • ,
  • Simona Pop

      Affiliations

    • Department of Medical Oncology, Institut Curie, Paris, France
    • ,
  • Véronique Diéras

      Affiliations

    • Department of Medical Oncology, Institut Curie, Paris, France
    • ,
  • Patricia Tresca

      Affiliations

    • Department of Medical Oncology, Institut Curie, Paris, France
    • ,
  • Xavier Paoletti

      Affiliations

    • Department of Biostatistics, INSERM U900, Institut Curie, Paris, France

Received 4 February 2011 ,Revised 14 March 2011 ,Accepted 14 March 2011.

Title About Type File Size
Supplementary data 1 Other 0 MB
Supplementary data 2 Other 0 MB

Please note that add-on components may require plug-in applications.

PII: S0959-8049(11)00191-2

doi: 10.1016/j.ejca.2011.03.016

European Journal of Cancer
Volume 47, Issue 10 , Pages 1468-1475 , July 2011

Article Tools