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Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo

  • Ryuta Arai

      Affiliations

    • Laboratory of Pathophysiology and Signal Transduction, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • Department of Orthopaedic Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    • ,
  • Masumi Tsuda

      Affiliations

    • Laboratory of Pathophysiology and Signal Transduction, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • Corresponding Author InformationCorresponding author: Address: Laboratory of Pathophysiology and Signal Transduction, Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo 060-8638, Japan. Tel.: +81 11 706 5158; fax: +81 11 706 7877.
    • ,
  • Takuya Watanabe

      Affiliations

    • Laboratory of Pathophysiology and Signal Transduction, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • Department of Orthopaedic Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    • ,
  • Toyoyuki Ose

      Affiliations

    • Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    • ,
  • Chikashi Obuse

      Affiliations

    • Graduate School of Life Science, Hokkaido University, Sapporo, Japan
    • ,
  • Katsumi Maenaka

      Affiliations

    • Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    • ,
  • Akio Minami

      Affiliations

    • Department of Orthopaedic Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan
    • ,
  • Yusuke Ohba

      Affiliations

    • Laboratory of Pathophysiology and Signal Transduction, Hokkaido University Graduate School of Medicine, Sapporo, Japan

Published online 16 January 2012 Corrected Proof

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PII: S0959-8049(11)01077-X

doi: 10.1016/j.ejca.2011.12.028

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