| Current Perspective |
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Article Title |
Author(s) |
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Recent advances in the management of colorectal cancer
After several decades of modest progress in the management of colorectal cancer, the recent identification of colorectal cancer genes, increased understanding of colorectal carcinogenesis, the introdu...
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E Van Cutsem,
M Dicato,
J Wils
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Full-length article
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pages 2302-2309
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Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution
Abstract: We carried out a retrospective study on the infection rate—in episodes per 100 person months at risk (p/m/r)—of septicaemia and invasive mycoses in children with solid tumours treated at a s...
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R Haupt,
M Romanengo,
T Fears,
C Viscoli,
E Castagnola
et al.
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Full-length article
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pages 2413-2419
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Additional value of electrical impedance scanning: experience of 240 histologically-proven breast lesions
Abstract: The aim of this study was to quantify the clinical value of using electrical impedance scanning (EIS) as an adjunct to other diagnostic techniques in order to identify cancerous tissue based...
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A Malich,
T Böhm,
M Facius,
M Freessmeyer,
M Fleck,
R Anderson,
W.A Kaiser
et al.
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Full-length article
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pages 2324-2330
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Locally advanced primary breast cancer: medium-term results of a randomised trial of multimodal therapy versus initial hormone therapy
Abstract: We report the medium-term (median follow-up=52 months) results of a prospective randomised trial of multimodal therapy (neoadjuvant chemotherapy, Patey mastectomy, postoperative radiotherapy...
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S.M Tan,
K.L Cheung,
P.C Willsher,
R.W Blamey,
S.Y Chan,
J.F.R Robertson
et al.
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Full-length article
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pages 2331-2338
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Genetic epidemiology of BRCA1 mutations in Norway
Abstract: Familial breast-ovarian cancer has been demonstrated to be frequent but unevenly distributed in Norway. This was assumed to be caused by the reduced population size created by the medieval B...
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P Møller,
K Heimdal,
J Apold,
Å Fredriksen,
Å Borg,
E Hovig,
A Hagen,
B Hagen,
J.C Pedersen,
L Mæhle,
The Norwegian Inherited Breast Cancer Group, The Norwegian Inherited Ovarian Cancer Group
et al.
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Full-length article
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pages 2428-2434
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Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat
Abstract: The aim of this study was to determine the influence of oxaliplatin scheduling on the onset of peripheral neurotoxicity and ototoxicity in a rat model. Animals were treated with four differe...
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G Cavaletti,
G Tredici,
M.G Petruccioli,
E Dondè,
P Tredici,
P Marmiroli,
C Minoia,
A Ronchi,
M Bayssas,
G Griffon Etienne
et al.
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Full-length article
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pages 2457-2463
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| Editorial Comment |
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Article Title |
Author(s) |
Type |
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Future trends in the treatment of brain tumours
An international meeting on new developments in brain tumours was held in Padova on 16–17 March focusing on the challenges and perspectives of treating gliomas. Malignant gliomas, despite their low in...
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A.A Brandes,
D Lacombe,
C Vecht
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Editorial
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pages 2297-2301
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Screening of selected genomic areas potentially involved in thyroid neoplasms
Abstract: Loss of heterozygosity (LOH) studies have been used to identify sites harbouring tumour suppressor genes (TSGs) involved in tumour initiation or progression. To further elucidate the genetic...
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J Oriola,
I Halperin,
C Mallofré,
J Muntané,
M Angel,
F Rivera-Fillat
et al.
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Full-length article
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pages 2470-2474
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Ductal carcinoma in situ of the breast results of conservative and radical treatments in 716 patients
Abstract: Until now, less than 5% of the patients with breast ductal carcinoma in situ (DCIS) have been enrolled in clinical trials. Consequently, we have analysed the results of ‘current practice’ am...
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B. Cutuli,
C. Cohen-Solal-Le Nir,
B. De Lafontan,
H. Mignotte,
V. Fichet,
R. Fay,
V. Servent,
S. Giard,
C. Charra-Brunaud,
H. Auvray,
F. Penault-Llorca,
J.-C. Charpentier
et al.
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Full-length article
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pages 2365-2372
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Biochemical responses in cultured cells following exposure to 89SrCl2: potential relevance to the mechanism of action in pain palliation
Abstract: 89SrCl2 is currently used as a systemic radioactive palliative treatment for painful osseous metastases associated with an osteoblastic reaction in bone. However, the biological mechanism by...
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J Davis,
R.J Pither
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Full-length article
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pages 2464-2469
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Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer
Abstract: Components of the urokinase plasminogen activator (u-PA) system are involved in the metastatic process, and have accordingly been associated with clinical outcome in a variety of malignant t...
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M Fredstorp-Lidebring,
P.-O Bendahl,
N Brünner,
B Casslén,
T Högberg,
E Långström-Einarsson,
R Willén,
M Fernö
et al.
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Full-length article
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pages 2339-2348
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Quality of life measurement in oncology—a matter of the assessment instrument?
Abstract: Two widely used quality of life questionnaires European Organization for Research and Treatment of Cancer Core (EORTC QLQ-C30), Functional Assessment of Cancer Therapy—General (FACT-G) were ...
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B Holzner,
G Kemmler,
B Sperner-Unterweger,
M Kopp,
M Dünser,
R Margreiter,
I Marschitz,
D Nachbaur,
W.W Fleischhacker,
R Greil
et al.
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Full-length article
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pages 2349-2356
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pRb-expressing adenovirus Ad5-Rb attenuates the p53-induced apoptosis in cervical cancer cell lines
Abstract: The retinoblastoma protein (pRb), the gene product of the first reported tumour suppressor gene, is functionally inactivated by the E7 protein of high-risk human papillomavirus (HPV) found i...
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S.M Ip,
T.-G Huang,
W.S.B Yeung,
H.Y.S Ngan
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Full-length article
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pages 2475-2483
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| Review |
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Article Title |
Author(s) |
Type |
Pages |
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Combination chemotherapy of the taxanes and antimetabolites: its use and limitations
Abstract: In an effort to improve response rates of chemotherapy, taxanes have been combined with other cytotoxic agents such as antimetabolites. However, the use of some of these combinations in pati...
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C.H Smorenburg,
A Sparreboom,
M Bontenbal,
J Verweij
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Full-length article
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pages 2310-2323
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Tanning habits and sunburn in a Swedish population age 13–50 years
Abstract: As part of a skin cancer control programme, we studied the occurrence of self-reported outdoor tanning, sunbed use and ultraviolet (UV)-induced erythema in an urban area. A cross-sectional q...
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C Boldeman,
R Bränström,
H Dal,
S Kristjansson,
Y Rodvall,
B Jansson,
H Ullén
et al.
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Full-length article
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pages 2441-2448
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Salivary and plasma pharmacokinetics of topotecan in patients with metastatic epithelial ovarian cancer
Abstract: The comparative saliva/plasma pharmacokinetics of topotecan were investigated in 13 patients with metastatic epithelial ovarian cancer receiving topotecan (30-min intravenous (i.v.) infusion...
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M. Boucaud,
F. Pinguet,
S. Poujol,
G. Romieu,
D. Cupissol,
C. Astre,
S. Culine,
F. Bressolle
et al.
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Full-length article
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pages 2357-2364
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Inhibition of tumour growth and metastasis of human fibrosarcoma cells HT-1080 by monoclonal antibody BCD-F9
Abstract: BCD-F9 is a murine IgG2a monoclonal antibody (mAb) that recognises a conformational epitope found on the surface of many human tumour cells. The aim of this study was to investigate the abil...
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M Popkov,
S Sidrac-Ghali,
Y Lusignan,
S Lemieux,
R Mandeville
et al.
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Full-length article
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pages 2484-2492
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Multiple primary cancer incidence in Italy
Abstract: Data collected from eleven Italian population-based cancer registries (overall population 7 200 000 inhabitants) were used to compute the incidence of second independent cancers (MP) in a co...
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E Crocetti,
E Buiatti,
P Falini,
the Italian Multiple Primary Cancer Working Group
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Full-length article
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pages 2449-2456
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The introduction of mammographical screening has had little effect on the trend in breast-conserving surgery: a population-based study in Southeast Netherlands
Abstract: In addition to reducing breast cancer mortality, breast cancer screening programmes are expected to increase the proportion of patients who can undergo breast-conserving surgery. Trends in t...
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M.F Ernst,
A.C Voogd,
J.W.W Coebergh,
O.J Repelaer van Driel,
J.A Roukema
et al.
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Full-length article
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pages 2435-2440
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Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment
Abstract: We present the 5-year results of the effect of adjuvant chemotherapy on bone mineral density (BMD) and the efficacy of clodronate in the prevention of bone loss in 73 premenopausal women wit...
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L Vehmanen,
T Saarto,
I Elomaa,
P Mäkelä,
M Välimäki,
C Blomqvist
et al.
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Full-length article
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pages 2373-2378
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Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery
Abstract: The serum concentrations of the cell adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 63 patients...
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D Alexiou,
A.J Karayiannakis,
K.N Syrigos,
A Zbar,
A Kremmyda,
I Bramis,
C Tsigris
et al.
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Full-length article
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pages 2392-2397
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Lack of efficacy of twice-weekly urokinase in the prevention of complications associated with Hickman catheters: a multicentre randomised comparison of urokinase versus heparin
Abstract: Hickman catheters (HC) are associated with complications, in particular infection, occlusion and thrombosis. We tested the hypothesis that regular flushing of catheters with urokinase would ...
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B Solomon,
J Moore,
C Arthur,
H.M Prince
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Full-length article
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pages 2379-2384
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Phase I trial of weekly irinotecan combined with UFT as second-line treatment for advanced colorectal cancer
Abstract: The aim of this study was to determine the maximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of weekly Irinotecan (CPT-11) plus UFT, and to assess the antitumour activity of this...
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V Alonso,
P Escudero,
M Zorrilla,
M.D Isla,
A Herrero,
J.I Mayordomo,
J Martinez-Trufero,
A Sáenz,
A Tres,
A Antón
et al.
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Full-length article
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pages 2385-2391
|
| Paediatric Update |
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Article Title |
Author(s) |
Type |
Pages |
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Rational use of blood products
Abstract: Blood product transfusions can be life saving and must be considered in the supportive care of children of any age with underlying oncological or haematological problems, as well as after ma...
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B.G Solheim,
F Wesenberg
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Full-length article
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pages 2421-2425
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Commentary
There are increasing pressures to use blood ‘rationally’, i.e. to give the safest, most effective product, in an appropriate dose when there is no reasonable alternative. Clinical governance concerns ...
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A.A.M Todd
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Discussion
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pages 2425-2427
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Gene transfer into solid tumours—is a special application device beneficial?
Abstract: The replacement of inactivated tumour suppressor genes is a promising approach in cancer therapy. The aim of this study was to evaluate the influence of technical determinants on the efficie...
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U Liebers,
H Kuhn,
W Arnold,
B Schmidt,
G Wolff,
C Witt
et al.
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Full-length article
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pages 2493-2499
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Randomised comparison of ondansetron plus dexamethasone with dexamethasone alone for the control of delayed cisplatin-induced emesis
Abstract: The role of 5-hydroxytryptamine3 (HT3) antagonists in the treatment of delayed emesis is still controversial. To evaluate whether 5-HT3 antagonists can add to the efficacy of corticosteroids...
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H. Tsukada,
T. Hirose,
A. Yokoyama,
Y. Kurita
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Full-length article
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pages 2398-2404
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Subcellular localisation of cyclin B, Cdc2 and p21WAF1/CIP1 in breast cancer: association with prognosis
Abstract: The heterodimeric cyclin B/Cdc2 protein kinase governs entry into mitosis, and can be negatively regulated through p53-mediated transcriptional induction of the cyclin-dependent kinase inhib...
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Z.E Winters,
N.C Hunt,
M.J Bradburn,
J.A Royds,
H Turley,
A.L Harris,
C.J Norbury
et al.
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Full-length article
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pages 2405-2412
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Miscellaneous
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Miscellaneous
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pages xi-xii
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Referees — 2001
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Miscellaneous
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pages 2500-2501
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News
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News
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pages 2291-2295
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Author Index
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Miscellaneous
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pages 2551-2558
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