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Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression
Abstract: Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. The relevance of the measurement of DPD activity for identifying DPD-deficient patients i...
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B Porsin,
J.-L Formento,
E Filipski,
M.-C Etienne,
M Francoual,
N Renée,
N Magné,
F Lévi,
G Milano
et al.
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Full-length article
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pages 822-828
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| Erratum |
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Erratum to “The requirements of a specialist breast unit” [European Journal of Cancer, 36 (2000) 2288–2293]
The Publisher regrets that an error has occurred in the published article mentioned above. On page 2291, Section 5.3, (iv), (b), faxitron should correctly appear as Faxitron®. We apologise for any inc...
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EUSOMA
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Erratum
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page 847
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| Corrigendum |
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Corrigendum to “Cancer burden in the year 2000. The global picture” [European Journal of Cancer, 37(Suppl. 8) (2001) S4–S66]
Tables 1–3 and Figs. 1–5 were updated, but several of the corresponding numbers in the text were unfortunately not. The following changes should be made:p S8: Paragraph 2, line 3: insert ‘, colorectum...
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D.M. Parkin,
F.I. Bray,
S.S. Devesa
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Erratum
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page 848
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| Review |
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Potential role of magnetic resonance spectroscopy in assessment of tumour response in childhood cancer
Abstract: This brief review considers to what extent Magnetic Resonance Spectroscopy (MRS) can play a role in monitoring early tumour response with examples of preclinical studies and selected clinica...
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S.J. Vaidya,
Geoffrey S. Payne,
Martin O. Leach,
C.R. Pinkerton
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Full-length article
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pages 728-735
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Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL)
Abstract: Treosulfan (L-threitol-1,4-bis-methanesulphonate; Ovastat®) is a bifunctional alkylating drug indicated for the treatment of advanced ovarian carcinoma. Recent data revealed immunosuppressiv...
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I. Fichtner,
M. Becker,
J. Baumgart
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Full-length article
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pages 801-807
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An EORTC-ECSG phase I study of LU 79553 administered every 21 or 42 days in patients with solid tumours
Abstract: A single-agent dose-escalating phase I and pharmacokinetic study on the naphthalamide agent, LU 79553, was performed to determine its safety profile, maximum tolerated dose (MTD) and recomme...
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A Awada,
R Thödtmann,
M.J Piccart,
J Wanders,
A.H.G.J Schrijvers,
I.-M Von Broen,
A.R Hanauske
et al.
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Full-length article
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pages 742-747
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An economic evaluation of the optimal workload in treating surgical patients in a breast unit
Abstract: A breast unit is a cancer centre specialised in the diagnosis and treatment of patients with breast cancer. The high level of specialised skills involved in running a breast unit makes it an...
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E Pagano,
A Ponti,
E Gelormino,
F Merletti,
M.P Mano
et al.
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Full-length article
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pages 748-754
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Age-specific norms and determinants of anxiety and depression in 731 women with breast cancer recruited through a population-based cancer registry
Abstract: The aim of this study was to determine population norms and determinants of anxiety and depression in a population-based sample of 731 women with breast cancer (aged 23–60 years) with the Ho...
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R.H Osborne,
G.R Elsworth,
J.L Hopper
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Full-length article
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pages 755-762
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Study of in vitro and in vivo effects of the piperidine nitroxide Tempol—a potential new therapeutic agent for gliomas
Abstract: The identification of novel therapeutic agents for the management of malignant gliomas represents an area of active research. Here, we show that Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidi...
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M.B Gariboldi,
R Ravizza,
C Petterino,
M Castagnaro,
G Finocchiaro,
E Monti
et al.
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Full-length article
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pages 829-837
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Concurrent sequencing of full-dose CMF chemotherapy and radiation therapy in early breast cancer has no effect on treatment delivery
Abstract: With the increasing use of breast-conserving therapy plus systemic chemotherapy for the treatment of early breast cancer, the optimal sequencing of radiation therapy and chemotherapy remains...
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C. Faul,
A. Brufsky,
K. Gerszten,
J. Flickinger,
A. Kunschner,
H. Jacob,
V. Vogel
et al.
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Full-length article
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pages 763-768
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Measurement of an apoptotic product in the sera of breast cancer patients
Abstract: During apoptosis, a number of intracellular proteins are cleaved by caspases. The intermediate filament protein cytokeratin 18 (CK18) is cleaved at Asp238 and Asp396. A monoclonal antibody, ...
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T Ueno,
M Toi,
K Bivén,
H Bando,
T Ogawa,
S Linder
et al.
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Full-length article
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pages 769-774
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| Editorial Comment |
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The best of times…the worst of times
Times are good for the study of biological pacemakers. With the sequencing of the human genome has come a rapid increase in understanding of the complex function and control of ‘clock genes’. In mamma...
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G.F. Fleming
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Editorial
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pages 715-717
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| Review |
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Pregnancy after breast cancer
Abstract: The issue of pregnancy in patients previously treated for breast cancer is controversial. This paper reviews the literature using Medline and Embase databases over the last 50 years to addre...
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S.S Upponi,
F Ahmad,
I.S Whitaker,
A.D Purushotham
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Full-length article
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pages 736-741
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Second malignant neoplasms after treatment of childhood cancer
Abstract: The aim of this study was to determine therapy-related risk factors for the development of second malignant neoplasm (SMN) after childhood cancer. The German Childhood Cancer Registry (GCCR)...
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G Klein,
J Michaelis,
C Spix,
R Wibbing,
G Eggers,
J Ritter,
P Kaatsch
et al.
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Full-length article
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pages 808-817
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Analysis of salvage treatments for germ cell cancer patients who have relapsed after primary high-dose chemotherapy plus autologous stem cell support
Abstract: The aim of this study was to identify treatment strategies and therapeutic or clinical factors that predict for response to salvage therapy and survival in patients with metastatic ‘Indiana ...
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C. Kollmannsberger,
N. Schleucher,
O. Rick,
B. Metzner,
J.T. Hartmann,
P. Schöffski,
J. Beyer,
J. Casper,
M. Sosada,
H.-J. Schmoll,
I. Böhlke,
C. Meisner,
L. Kanz,
C. Bokemeyer
et al.
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Full-length article
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pages 775-782
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Unexpected reduction of mortality rates from melanoma in males living in central Italy
Abstract: A registry-based study has been carried out in central Italy to investigate cutaneous melanoma incidence and mortality trends. The incidence of invasive (1492 cases analysed) and in situ (22...
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E. Crocetti,
Paolo Carli
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Full-length article
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pages 818-821
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Lack of c-kit exon 11 activating mutations in c-KIT/CD117-positive SCLC tumour specimens
Abstract: Previous studies have shown that STI571, a selective tyrosine kinase inhibitor of c-KIT, is highly effective in c-KIT/CD117-positive gastrointestinal stromal tumours (GIST), especially those...
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H. Burger,
M.A. den Bakker,
G. Stoter,
J. Verweij,
K. Nooter
et al.
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Full-length article
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pages 793-799
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The radiosensitising effect of gemcitabine and the influence of the rescue agent amifostine in vitro
Abstract: In this study, the radiosensitising effect of different concentrations of gemcitabine and the combination of gemcitabine/radiotherapy with the rescue agent amifostine was investigated in dif...
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B Pauwels,
A.E.C Korst,
C.M.J de Pooter,
H.A.J Lambrechts,
G.G.O Pattyn,
F Lardon,
J.B Vermorken
et al.
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Full-length article
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pages 838-846
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Outcome analysis of 189 consecutive cancer patients referred to the intensive care unit as emergencies during a 2-year period
Abstract: The referral of critically ill cancer patients to an intensive care unit (ICU) is a matter of controversial debate. This study was conducted by an interdisciplinary clinical group to evaluat...
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G. Maschmeyer,
F.-L. Bertschat,
K.T. Moesta,
E. Häusler,
T.K. Held,
M. Nolte,
K.-J. Osterziel,
V. Papstein,
M. Peters,
G. Reich,
M. Schmutzler,
O. Sezer,
M. Stula,
H. Wauer,
T. Wörtz,
M. Wischnewsky,
P. Hohenberger
et al.
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Full-length article
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pages 783-792
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Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines
Abstract: In recent years, numerous serum and cell/tissue-based markers have been described for colorectal cancer (CRC). The aim of this article was to provide guidelines for the routine clinical use ...
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M.J Duffy,
A van Dalen,
C Haglund,
L Hansson,
R Klapdor,
R Lamerz,
O Nilsson,
C Sturgeon,
O Topolcan
et al.
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Full-length article
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pages 718-727
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Miscellaneous
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Miscellaneous
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pages ix-x
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News
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News
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pages 709-713
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Editorial board - repeat
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Miscellaneous
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page ii
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Calendar - update
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Calendar
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pages I-II
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