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Editorial board - repeat
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Miscellaneous
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page ii
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Miscellaneous
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Miscellaneous
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pages 849-850
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News
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News
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pages 851-855
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| Editorial |
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Histological measurement of tumour angiogenesis
The study by Offersen and colleagues in this issue has added valuable insights into the interesting, but confused, area of tumour vascularity measurement . Supply of oxygen, nutrients and growth facto...
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J. Boyle
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Editorial
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pages 859-860
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| Review |
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The use of gonadotrophin-releasing hormone (GnRH) agonists in early and advanced breast cancer in pre- and perimenopausal women
Abstract: Gonadotrophin-releasing hormone (GnRH) agonists, in particular goserelin (‘Zoladex’), are increasingly being used for the treatment of breast cancer in women with functioning ovaries. They a...
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J.F.R. Robertson,
R.W. Blamey
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Full-length article
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pages 861-869
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Geriatric oncology: a clinical approach to the older patient with cancer
Abstract: Due to the ageing of the population and the sharp increase in life expectancy, cancer in the older person has become an increasingly common problem in the Western world. Although several aut...
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L. Repetto,
A. Venturino,
L. Fratino,
D. Serraino,
G. Troisi,
W. Gianni,
M. Pietropaolo
et al.
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Review article
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pages 870-880
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Quantification of angiogenesis as a prognostic marker in human carcinomas: a critical evaluation of histopathological methods for estimation of vascular density
Abstract: Chalkley counts have been suggested as the primary method for immunohistochemical evaluation of angiogenesis, however, most studies have used microvessel density (MVD). We present paired Cha...
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B.V Offersen,
M Borre,
J Overgaard
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Full-length article
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pages 881-890
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Effects of low dose tamoxifen on normal breast tissue from premenopausal women
Abstract: The aim of this study was to determine the effects of low doses of tamoxifen (5 and 10mg/day) for 50 days compared with the standard dose (20 mg/day) on breast biomarkers measured in normal ...
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G.R. de Lima,
G. Facina,
J.Y. Shida,
M.B.C. Chein,
P. Tanaka,
R.C. Dardes,
V.C. Jordan,
L.H. Gebrim
et al.
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Full-length article
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pages 891-898
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Immunoassays of urokinase (uPA) and its type-1 inhibitor (PAI-1) in detergent extracts of breast cancer tissue
Abstract: Two immunoassays for quantitation of the biological markers uPA and PAI-1 were evaluated for their use with detergent extracts of breast cancer tissue. Both assays were based on murine monoc...
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A.N Pedersen,
H.T Mouridsen,
D.Y Tenney,
N Brünner
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Full-length article
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pages 899-908
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Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade
Abstract: The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to...
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R Komdeur,
B.E.C Plaat,
W.T.A van der Graaf,
H.J Hoekstra,
H Hollema,
E van den Berg,
N Zwart,
R.J Scheper,
W.M Molenaar
et al.
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Full-length article
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pages 909-916
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Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins αvβ3 and αvβ5 in patients with advanced solid tumours
Abstract: A single-agent dose escalating phase I and pharmacokinetic study with Cilengitide, an inhibitor of the integrins αvβ3 and αvβ5, was performed to determine its safety and toxicity. Cilengitid...
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F.A.L.M Eskens,
H Dumez,
R Hoekstra,
A Perschl,
C Brindley,
S Böttcher,
W Wynendaele,
J Drevs,
J Verweij,
A.T van Oosterom
et al.
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Full-length article
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pages 917-926
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Rapid intravenous administration of granisetron prior to chemotherapy is not arythmogenic: results of a pilot study
Abstract: Patients with advanced malignancy are at an increased risk of cardiac arrhythmias, from their cancer and cardiotoxic treatments. Supportive care products co-administered should therefore not...
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M Aapro,
J.P Bourke
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Full-length article
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pages 927-931
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Can patient-, treatment- and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients?
Abstract: The aim of this study was to identify patient-, tumour- or treatment-related factors associated with young age that might explain the higher risk of ipsilateral breast recurrence that occurs...
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C Vrieling,
L Collette,
A Fourquet,
W.J Hoogenraad,
J.-C Horiot,
J.J Jager,
S Bing Oei,
H.L Peterse,
M Pierart,
P.M Poortmans,
H Struikmans,
W Van den Bogaert,
H Bartelink,
on behalf of the EORTC Radiotherapy, Breast Cancer Groups
et al.
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Full-length article
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pages 932-944
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Quality of life in breast cancer patients aged over 70 years, participating in the EORTC 10850 randomised clinical trial
Abstract: Mastectomy and breast-conserving treatment have proven equally effective in terms of survival in early breast cancer, but studies continue to provide evidence that patients undergoing breast...
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J.C.J.M de Haes,
D Curran,
N.K Aaronson,
I.S Fentiman,
On behalf of the European Organisation for Research and Treatment of Cancer (EORTC) Breast Cancer Cooperative Group (BCCG)
et al.
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Full-length article
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pages 945-951
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Population-based survival after childhood lymphoblastic leukaemia in time periods corresponding to specific clinical trials from 1979 to 1998—a report from the Childhood Cancer Registry of Piedmont (Italy)
Abstract: This study evaluated the outcome after childhood acute lymphoblastic leukaemia (ALL) in a population aged 0–14 years served by the Childhood Cancer Registry of Piedmont (CCRP) during the acc...
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G Pastore,
S Viscomi,
G.L Gerov,
B Terracini,
E Madon,
C Magnani
et al.
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Full-length article
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pages 952-960
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Increased incidence of renal parenchymal carcinoma in the Northern and Yorkshire region of England, 1978–1997
Abstract: Kidney cancer remains relatively rare, but incidence and mortality rates are reported to be rising steadily across the world. To determine if such increases were occurring in the UK, we exam...
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R Tate,
R Iddenden,
P Harnden,
E Morris,
C Craigs,
C Bennett,
C Brook,
R.A Haward,
D Forman
et al.
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Full-length article
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pages 961-967
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A randomised population-based intervention to examine the effects of the ultraviolet index on tanning behaviour
Abstract: The aim of the following study was to examine the effects of the Ultraviolet (UV) Index and a personal ultraviolet radiation (UVR) intensity indicator on tanning behaviour compared with gene...
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R. Bränström,
H. Ullén,
Y. Brandberg
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Full-length article
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pages 968-974
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Chromosomal imbalances associated with acquired resistance to fluoropyrimidines in human colorectal cancer cells
Abstract: The chromosomal aberrations underlying the development of resistance to fluoropyrimidines have not yet been identified. To characterise the genomic changes that induce the development of res...
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S Hidaka,
T Yasutake,
M Fukushima,
H Yano,
M Haseba,
T Tsuji,
T Sawai,
H Yamaguchi,
T Nakagoe,
H Ayabe,
Y Tagawa
et al.
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Full-length article
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pages 975-980
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The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology
Abstract: The aim of this study was to determine the expression of proteinases and inhibitors from the matrix metalloproteinase (MMP) (MMPs 1, 2, 3, 9, tissue inhibitors of metalloproteinases (TIMPs) ...
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E.A Baker,
D.J Leaper
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Full-length article
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pages 981-988
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A proteome study of secreted prostatic factors affecting osteoblastic activity: identification and characterisation of cyclophilin A
Abstract: Prostate cancer cells metastasise to bone causing a predominantly osteosclerotic response. It has previously been shown that PC3 cells secrete factors which stimulate the mitogenic activity ...
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H Andersen,
O.N Jensen,
E.F Eriksen
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Full-length article
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pages 989-995
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γ-Glutamyl transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidney
Abstract: Nephrotoxicity is a side-effect and the main factor limiting the clinical use of cisplatin. In vivo, the administration of the cysteine-containing tripeptide glutathione (GSH) has been found...
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A Paolicchi,
M Sotiropuolou,
P Perego,
S Daubeuf,
A Visvikis,
E Lorenzini,
M Franzini,
N Romiti,
E Chieli,
R Leone,
P Apostoli,
D Colangelo,
F Zunino,
A Pompella
et al.
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Full-length article
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pages 996-1003
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Induction of 5α-reductase type II mRNA transcription in primary cultured prostate epithelial cells by a soluble factor produced by primary cultured prostate fibroblast cells
Abstract: The role of DHT in the development of BPH has resulted in the formulation of several drugs, which have been designed to inhibit the formation of DHT by the 5α-reductase enzymes (5α-reductase...
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C.W. Bayne,
M. Ross,
N.F. Inglis
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Full-length article
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pages 1004-1011
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Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague–Dawley rats
Abstract: The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary...
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A.I. Constantinou,
R. Mehta,
A. Husband
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Full-length article
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pages 1012-1018
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Blood glutathione as a surrogate marker of cancer tissue glutathione S-transferase activity in non-small cell lung cancer and squamous cell carcinoma of the head and neck
Abstract: The identification of markers predicting the response to therapy is of the utmost importance in oncology. Several authors have suggested that increased levels of glutathione (GSH) and glutat...
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E Ferruzzi,
R Franceschini,
G Cazzolato,
C Geroni,
C Fowst,
U Pastorino,
N Tradati,
J Tursi,
R Dittadi,
M Gion
et al.
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Full-length article
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pages 1019-1029
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Calendar - repeat
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Calendar
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page I
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