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Editorial board
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Editorial board
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page ii
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Ten Most Popular EJC Papers
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Miscellaneous
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page ix
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In this issue
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Miscellaneous
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page xiii
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Forthcoming papers
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Miscellaneous
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page xiv
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EJC NEWS
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News
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pages 1-5
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| Editorial Comment |
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The two-faced keeper of gates to heaven
There are several reasons why Janus the ancient roman god might be adopted as a patron of oncology. Suitably the guardian of the Gate of Heaven, Janus was represented with two faces, one in front and ...
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John Smyth
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Discussion
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pages 6-7
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| Current Perspective |
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Adjuvant chemotherapy for non-small cell lung cancer: Ready for clinical practice?
Abstract: Radical surgery remains the only treatment with curative potential for patients with operable non-small cell lung cancer (NSCLC). However, despite complete surgical resection, long-term surv...
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M. Tiseo,
V. Franciosi,
F. Grossi,
A. Ardizzoni
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Full-length article
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pages 8-16
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| Reviews |
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Mutations of the epidermal growth factor receptor in non-small cell lung cancer – Search and destroy
Abstract: The targeting of the ATP binding pocket of the epidermal growth factor receptor (EGFR) tyrosine kinase, by the small molecule drugs gefitinib and erlotinib, represents a promising new therap...
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S.K. Chan,
W.J. Gullick,
M.E. Hill
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Full-length article
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pages 17-23
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Peripheral neuropathy: A persisting challenge in paclitaxel-based regimes
Abstract: Cumulative peripheral neuropathy (PNP) still remains a limitation to optimal treatment with paclitaxel (PAC), especially in more dose–dense schedules. This primary sensory PNP may affect the...
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Stephan Mielke,
Alex Sparreboom,
Klaus Mross
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Full-length article
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pages 24-30
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Prevention and treatment of cancer cachexia: New insights into an old problem
Abstract: Cancer cachexia (CC) is a multifactorial paraneoplastic syndrome characterized by anorexia, body weight loss, loss of adipose tissue and skeletal muscle, accounting for at least 20% of death...
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Maurizio Muscaritoli,
Maurizio Bossola,
Zaira Aversa,
Rocco Bellantone,
Filippo Rossi Fanelli
et al.
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Full-length article
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pages 31-41
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| Clinical Oncology |
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Does a patient’s self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?
Abstract: The purpose of this study was to determine whether baseline patients’ self reported health-related quality of life (HRQOL) parameters could predict survival beyond key biomedical prognostic ...
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Fabio Efficace,
Andrew Bottomley,
Corneel Coens,
Kristel Van Steen,
Thierry Conroy,
Patrick Schöffski,
Hans Schmoll,
Eric Van Cutsem,
Claus-Henning Köhne
et al.
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Full-length article
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pages 42-49
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Seven year update of an EORTC phase III trial of high-dose intensity M-VAC chemotherapy and G-CSF versus classic M-VAC in advanced urothelial tract tumours
Abstract: EORTC protocol 30924 is an international randomized trial reporting a 7.3 year update of a 2 weekly regimen of high-dose intensity chemotherapy with M-VAC plus granulocyte colony stimulating...
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C.N. Sternberg,
P. de Mulder,
J.H. Schornagel,
C. Theodore,
S.D. Fossa,
A.T. van Oosterom,
J.A. Witjes,
M. Spina,
C.J. van Groeningen,
B. Duclos,
J.T. Roberts,
C. de Balincourt,
L. Collette,
the EORTC Genito-Urinary Cancer Group
et al.
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Full-length article
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pages 50-54
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The development of the EORTC QLQ-C15-PAL: A shortened questionnaire for cancer patients in palliative care
Abstract: This study aimed at developing a shortened version of the EORTC QLQ-C30, one of the most widely used health-related quality of life questionnaires in oncology, for palliative care research. ...
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Mogens Groenvold,
Morten Aa. Petersen,
Neil K. Aaronson,
Juan I. Arraras,
Jane M. Blazeby,
Andrew Bottomley,
Peter M. Fayers,
Alexander de Graeff,
Eva Hammerlid,
Stein Kaasa,
Mirjam A.G. Sprangers,
Jakob B. Bjorner,
for the EORTC Quality of Life Group
et al.
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Full-length article
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pages 55-64
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| Paediatric Oncology |
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Unilateral retinoblastoma, lack of familial history and older age does not exclude germline RB1 gene mutation
Abstract: Conclusive identification of RB1 mutations in retinoblastoma is predicted to improve the clinical management of affected children and relatives. However, despite clear clinical benefits, RB1...
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Bénédicte Brichard,
Michel Heusterspreute,
Patrick De Potter,
Christophe Chantrain,
Christiane Vermylen,
Catherine Sibille,
Jean-Luc Gala
et al.
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Full-length article
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pages 65-72
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| Epidemiology and Cancer Prevention |
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Glutathione S-transferase M1 and T1 genetic polymorphisms are not related to the risk of hepatocellular carcinoma: A study in the Spanish population
Abstract: Glutathione S-transferases constitute a superfamily of enzymes that catalyse the inactivating conjugation of endogenous and environmental substrates involved in the pathogenesis of hepatocel...
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José M. Ladero,
Carmen Martínez,
Elena García-Martín,
Paloma Ropero,
Olga Briceño,
Ana Villegas,
Manuel Díaz-Rubio,
José A.G. Agúndez
et al.
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Full-length article
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pages 73-77
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Bayesian methods for early detection of changes in childhood cancer incidence: Trends for acute lymphoblastic leukaemia are consistent with an infectious aetiology
Abstract: Published data on time trends in the incidence of childhood leukaemia show inconsistent patterns, with some studies showing increases and others showing relatively stable incidence rates. Da...
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Milena Maria Maule,
Luisa Zuccolo,
Corrado Magnani,
Guido Pastore,
Paola Dalmasso,
Neil Pearce,
Franco Merletti,
Dario Gregori
et al.
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Full-length article
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pages 78-83
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Body mass index and colon cancer risk in Chinese people: Menopause as an effect modifier
Abstract: High body mass index (BMI) has consistently been associated with increased colon cancer risk in men, but not in women. It is hypothesised that menopause-related changes in oestrogen levels p...
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Lifang Hou,
Bu-Tian Ji,
Aaron Blair,
Qi Dai,
Yu-Tang Gao,
John D. Potter,
Wong-Ho Chow
et al.
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Full-length article
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pages 84-90
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| Experimental Oncology |
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Targeting CD99 in association with doxorubicin: An effective combined treatment for Ewing’s sarcoma
Abstract: CD99 is a 32kDa surface glycoprotein that is involved in the migration of leukocytes, cell–cell adhesion and apoptosis of T cells and Ewing’s sarcoma (ES) cells, two cell types with a high l...
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Katia Scotlandi,
Stefania Perdichizzi,
Ghislaine Bernard,
Giordano Nicoletti,
Patrizia Nanni,
Pier-Luigi Lollini,
Antonio Curti,
Maria Cristina Manara,
Stefania Benini,
Alain Bernard,
Piero Picci
et al.
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Full-length article
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pages 91-96
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Endothelial cell apoptosis in the context of quantification of angiogenesis in solid human adenocarcinomas: A novel double immunolabelling technique to identify endothelial cell apoptosis
Abstract: Standardised methods of microvessel density quantification have been published. However, a reliable and reproducible method to visualise endothelial cell apoptosis is lacking, which is a sho...
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Koert P. de Jong,
Peter B. Vermeulen,
Eric van Marck,
Marcel Boot,
Annette S.H. Gouw
et al.
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Full-length article
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pages 97-100
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Expression of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) as a prognostic indicator in gastric cancer
Abstract: In this study the expression levels of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) in gastric cancer cell lines and tissues have been analysed in order to assess their ...
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Sang Yong Song,
Hee Jung Son,
Eunsook Nam,
Jong Chul Rhee,
Chaehwa Park
et al.
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Full-length article
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pages 101-108
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Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma
Abstract: Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity to tyrosine kinase inhibitors (TKIs) and are pre...
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Judith Loeffler-Ragg,
Martina Witsch-Baumgartner,
Alexandar Tzankov,
Wolgang Hilbe,
Ilona Schwentner,
Georg M. Sprinzl,
Gerd Utermann,
Heinz Zwierzina
et al.
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Full-length article
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pages 109-111
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Vascular endothelial growth factors and receptors in colorectal cancer: Implications for anti-angiogenic therapy
Abstract: There are conflicting associations between growth factor expression and clinicopathological variables in colorectal cancer. This study aimed to define the expression of members of the VEGF f...
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Sarah E. Duff,
Maria Jeziorska,
Daniela D. Rosa,
Shant Kumar,
Najib Haboubi,
David Sherlock,
Sarah T. O’Dwyer,
Gordon C. Jayson
et al.
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Full-length article
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pages 112-117
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Calendar
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Calendar
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pages I-II
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