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Editorial board
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Editorial board
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page ii
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In this Issue
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Miscellaneous
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page xiv
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News
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News
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pages 567-571
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| Editorial Comment |
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Integrative oncology – What’s in a name?
[“That which we call a Rose by any other name would smell as sweet”, Shakespeare, Romeo & Juliet]
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John F. Smyth
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Discussion
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pages 572-573
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| Current Perspective |
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Chronomodulated chemotherapy for colorectal cancer: Failing the test of time?
The idea that chronopharmacology offers an exploitable advantage for cancer chemotherapy has been espoused for over two decades. However, despite our growing understanding of the importance of biologi...
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Chris H. Takimoto
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Full-length article
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pages 574-581
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| Reviews |
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Recent developments in the use of chemotherapy in brain tumours
Abstract: Several recent studies have further clarified the role of chemotherapy in newly diagnosed anaplastic glioma. For newly diagnosed glioblastoma, combined daily radiotherapy with daily temozolo...
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Martin J. van den Bent,
Monika E. Hegi,
Roger Stupp
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Full-length article
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pages 582-588
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Malignant ascites: Systematic review and guideline for treatment
Abstract: A guideline on the management of symptomatic malignant ascites by abdominal paracentesis, diuretics and peritoneovenous shunting, based on a systematic review of the literature is presented....
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Gerhild Becker,
Daniel Galandi,
Hubert E. Blum
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Full-length article
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pages 589-597
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High-throughput techniques in breast cancer: A clinical perspective
Abstract: High-throughput technologies such as DNA-microarrays, RT-PCR and proteomics can improve the prognostic and predictive information acquired from classical parameters. Unlike information gathe...
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Enrique Espinosa,
Andrés Redondo,
Juan Ángel Fresno Vara,
Pilar Zamora,
Enrique Casado,
Paloma Cejas,
Manuel González Barón
et al.
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Full-length article
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pages 598-607
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| Clinical Oncology |
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Randomised phase II study of standard versus chronomodulated CPT-11 plus chronomodulated 5-fluorouracil and folinic acid in advanced colorectal cancer patients
Abstract: In this study, a randomised phase II trial explored the effects of 6-h chronomodulated CPT-11 infusion in advanced colorectal cancer patients. Sixty-eight pre-treated patients were randomly ...
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Carlo Garufi,
Barbara Vanni,
Anna Maria Aschelter,
Albina Rita Zappalà,
Emilio Bria,
Cecila Nisticò,
Isabella Sperduti,
Francesco Cognetti,
Edmondo Terzoli
et al.
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Full-length article
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pages 608-616
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Intraoperative sentinel lymph node examination by frozen section, immunohistochemistry and imprint cytology during breast surgery – A prospective study
Abstract: The aim of this study was to compare the sensitivity of intraoperative frozen section with hematoxyllin-eosin (H&E) staining, immunohistochemistry (IHC) or imprint cytology (IC) in the a...
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F. Celebioglu,
M. Sylvan,
L. Perbeck,
L. Bergkvist,
J. Frisell
et al.
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Full-length article
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pages 617-620
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Risk-reducing surgery in women with familial susceptibility for breast and/or ovarian cancer
Abstract: This multicentre study examined uptake of bilateral risk-reducing mastectomy (BRRM) and bilateral risk-reducing oophorectomy (BRRO) in women at increased risk for breast and/or ovarian cance...
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Yoland Antill,
John Reynolds,
Mary-Anne Young,
Judy Kirk,
Katherine Tucker,
Tarli Bogtstra,
Shirley Wong,
Tracy Dudding,
Juliana Di Iulio,
Kelly-Anne Phillips
et al.
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Full-length article
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pages 621-628
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The association between Akt activation and resistance to hormone therapy in metastatic breast cancer
Abstract: In this retrospective study, the relationship between Akt activation and the efficacy of endocrine therapy for metastatic breast cancer was investigated. Thirty-six metastatic breast cancer ...
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Eriko Tokunaga,
Akemi Kataoka,
Yasue Kimura,
Eiji Oki,
Kojiro Mashino,
Kojiro Nishida,
Tadashi Koga,
Masaru Morita,
Yoshihiro Kakeji,
Hideo Baba,
Shinji Ohno,
Yoshihiko Maehara
et al.
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Full-length article
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pages 629-635
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Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients
Abstract: ERBB2 (HER2/Neu) gene amplification and overexpression is associated with increased risk of metastases and shorter survival in breast cancer. Tyrosine 1248 is a major phosphorylation site of...
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Jonas Cicenas,
Patrick Urban,
Willy Küng,
Vincent Vuaroqueaux,
Martin Labuhn,
Edward Wight,
Urs Eppenberger,
Serenella Eppenberger-Castori
et al.
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Full-length article
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pages 636-645
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| Paediatric Oncology |
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Mutational analysis of PDGFR–RAS/MAPK pathway activation in childhood medulloblastoma
Abstract: Aberrant signalling via platelet derived growth factor receptors (PDGFRs) and the RAS/MAPK pathway has been implicated in the development of medulloblastoma, the most common malignant brain ...
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Richard J. Gilbertson,
Jaqueline A. Langdon,
Andrew Hollander,
Roberto Hernan,
Twala L. Hogg,
Amar Gajjar,
Christine Fuller,
Steven C. Clifford
et al.
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Full-length article
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pages 646-649
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| Epidemiology and Cancer Prevention |
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Hormone replacement therapy is more prevalent among Jewish BRCA1/2 mutation carriers
Abstract: The aim of this study was to compare reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) in consecutive Jewish Ashkenazi breast cancer patients, with ...
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Revital Bruchim Bar Sade,
Angela Chetrit,
Arie Figer,
Moshe Z. Papa,
Dov Flex,
Shulamit Rizel,
Eitan Friedman
et al.
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Full-length article
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pages 650-655
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Skin cancer in survivors of childhood and adolescent cancer
Abstract: The incidence of basal cell carcinoma (BCC) has been related to ionizing radiation, particularly for exposure occurring at young age. In this study, we considered the incidence of second ski...
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Fabio Levi,
Raphael Moeckli,
Lalao Randimbison,
Van-Cong Te,
Manuela Maspoli,
Carlo La Vecchia
et al.
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Full-length article
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pages 656-659
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Time trends of incidence, mortality, and relative survival of invasive skin melanoma in Lithuania
Abstract: The aim of this study was to provide insights into the descriptive epidemiology of invasive skin melanoma in Lithuania by analyzing population-based incidence (1978–2002) and mortality (1990...
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Andreas Stang,
Skaidra Valiukeviciene,
Birute Aleknaviciene,
Juozas Kurtinaitis
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Full-length article
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pages 660-667
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| Experimental Oncology |
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Effects of down-regulating the Id genes in human colorectal cancer cells on early steps of haematogenous metastasis
Abstract: Id genes (inhibitor of DNA binding/differentiation) play important roles in tumour growth. We have previously described crucial roles of Id gene over-expression in endothelial cells for tumo...
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Yurai Okaji,
Nelson Hirokazu Tsuno,
Joji Kitayama,
Daisuke Sakurai,
Naoyuki Tsuchiya,
Shinsuke Saito,
Kenji Takegami,
Takeshi Tsuchiya,
Kazushige Kawai,
Kentaro Yazawa,
Masahiro Asakage,
Satomi Yoneyama,
Jun Yamada,
Katsushi Tokunaga,
Koki Takahashi,
Hirokazu Nagawa
et al.
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Full-length article
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pages 668-673
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Correlations between c-myc gene copy-number and clinicopathological parameters of ovarian tumours
Abstract: The objective of this study was to investigate increases in c-myc gene copy-number in ovarian tumours, and to analyze their correlations with clinicopathological parameters. Here we applied ...
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I. Dimova,
S. Raitcheva,
R. Dimitrov,
N. Doganov,
D. Toncheva
et al.
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Full-length article
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pages 674-679
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Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role
Abstract: Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by h...
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Arianna Palladini,
Annalisa Astolfi,
Stefania Croci,
Carla De Giovanni,
Giordano Nicoletti,
Angelo Rosolen,
Francesca Sartori,
Pier-Luigi Lollini,
Lorena Landuzzi,
Patrizia Nanni
et al.
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Full-length article
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pages 680-687
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Calendar
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Calendar
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pages I-II
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